[1]王月,综述,周建中,等.原发性高血压与水盐代谢相关基因研究进展[J].心血管病学进展,2016,(4):361-364.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.009]
　WANG Yue,ZHOU Jianzhong.Research Progress of Relationship Between Water-salt Metabolism Related Genes and Essential Hypertension[J].Advances in Cardiovascular Diseases,2016,(4):361-364.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.009]
点击复制

原发性高血压与水盐代谢相关基因研究进展()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年4期
页码:
361-364
栏目:
综述
出版日期:
2016-08-15

文章信息/Info

Title:
Research Progress of Relationship Between Water-salt Metabolism Related Genes and Essential Hypertension
作者:
王月; 综述; 周建中; 审校
重庆医科大学附属第一医院心血管内科,重庆 400016
Author(s):
WANG Yue;  ZHOU Jianzhong
Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China
关键词:
水盐代谢;  基因;  原发性高血压
Keywords:
Water-salt metabolism;  Gene;  Hypertension
分类号:
R544.1
DOI:
10.16806/j.cnki.issn.1004-3934.2016.04.009
文献标志码:
A
摘要:
原发性高血压是心血管疾病中最常见的疾病,其发病受遗传、环境及个人生活等因素影响。水盐代谢异常为原发性高血压发病机制之一,与水盐代谢相关的基因可能与原发性高血压的发病相关。现就原发性高血压与水盐代谢相关基因的研究进展做一综述。
Abstract:
Essential hypertension is the most common cardiovascular disease, and is influenced by genetics, environmental, and personal behavioral factors. The disorder of water-salt metabolism is one of the most important mechanisms of this disease,and its related genes may play an important role in the development of essential hypertension. This article reviews the current research progress of relationship between water-salt metabolism related genes and essential hypertension.

参考文献/References:

[1] 陈松苍, 罗莉, 谢良地. 原发性高血压的思考与展望[J]. 中华高血压杂志, 2013,(08):786-788.
[2] Liu F, Yang X, Mo X, et al. Associations of epithelial sodium channel genes with blood pressure: the GenSalt study[J]. J Hum Hypertens, 2015,29(4):224-228.
[3] Wang L, Zheng B, Zhao H, et al. α-Adducin gene G614T polymorphisms in essential hypertension patients with high low density lipoprotein(LDL)levels[J]. Indian J Med Res,2014,139(2):273-278.
[4] Choi HD, Suh JH, Lee JY, et al. Effects of ACE and ADD1 gene polymorphisms on blood pressure response to hydrochlorothiazide: a meta-analysis[J]. Int J Clin Pharmacol Ther,2013,51(9):718-724.
[5] Kundu A, Anand A. Computational study of ADD1 gene polymorphism associated with hypertension[J]. Cell Biochem Biophys,2013,65(1):13-19.
[6] Zhang LN, Ji LD, Fei LJ, et al. Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population[J]. Biomed Res Int,2013,2013:451094.
[7] Liao X, Wang W, Zeng Z, et al. Association of alpha- ADD1 gene and hypertension risk: a meta-analysis[J]. Med Sci Monit,2015,21:1634-1641.
[8] Chen J, Kleyman TR, Sheng S. Deletion of alpha-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module[J]. Am J Physiol Renal Physiol, 2014,306(5):F561- F567.
[9] Hanukoglu I, Hanukoglu A. Epithelial sodium channel(ENaC)family:phylogeny, structure-function,tissue distribution,and associated inherited diseases[J]. Gene, 2016,579(2):95-132.
[10] Yang W, Zhu Z, Wang J, et al. Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension[J]. Saudi Med J, 2015,36(9):1039-1045.
[11] Kone BC. Epigenetics and the control of the collecting duct epithelial sodium channel[J]. Semin Nephrol,2013,33(4):383-391.
[12] Zhang W. Epigenetics of epithelial Na(+)channel-dependent sodium uptake and blood pressure regulation[J]. World J Nephrol,2015,4(3):363-366.
[13] Boiko N, Kucher V, Stockand JD. Pseudohypoaldosteronism type 1 and Liddle's syndrome mutations that affect the single-channel properties of the epithelial Na+ channel[J]. Physiol Rep,2015,3(11):e12600.
[14] Wang J, Yu T, Yin L, et al. Novel mutations in the SCNN1A gene causing pseudohypoaldosteronism type 1[J]. PLoS One,2013,8(6):e65676.
[15] Nobel YR, Lodish MB, Raygada M, et al. Pseudohypoaldosteronism type 1 due to novel variants of SCNN1B gene[J]. Endocrinol Diabetes Metab Case Rep, 2016,2016:150104.
[16] Yang KQ, Xiao Y, Tian T, et al. Molecular genetics of Liddle's syndrome[J]. Clin Chim Acta,2014,436:202-206.
[17] Wang LP, Yang KQ, Jiang XJ, et al. Prevalence of Liddle syndrome among young hypertension patients of undetermined cause in a Chinese population[J]. J Clin Hypertens(Greenwich), 2015,17(11):902-907.
[18] Song W, Wang H, Wu Q. Atrial natriuretic peptide in cardiovascular biology and disease(NPPA)[J]. Gene,2015,569(1):1-6.
[19] Rubattu S, Sciarretta S, Volpe M. Atrial natriuretic peptide gene variants and circulating levels:implications in cardiovascular diseases[J]. Clin Sci(Lond), 2014,127(1):1-13.
[20] 韩雄毅,崔兰.延边地区人群rs2270915基因多态性与原发性高血压易感性的相关性研究[J].延边大学医学学报,2015,38(1):31-34.
[21] Chandra S, Saluja D, Narang R, et al. Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension:a case-control study[J]. Gene, 2015,567(1):92-97.
[22] 刘美玲, 李欢, 朱艳慧, 等. EMILIN1 CYP11B2基因多态性与原发性高血压相关性研究[J]. 检验医学与临床, 2014,(11):1471-1473.
[23] Ji X, Qi H, Li DB, et al. Associations between human aldosterone synthase CYP11B2(-344T/C)gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension[J]. Int J Clin Exp Med, 2015,8(1):1173-1177.
[24] Li W, Liu C. The -344C/T polymorphism in the CYP11B2 gene is associated with essential hypertension in the Chinese[J]. J Renin Angiotensin Aldosterone Syst, 2014,15(2):150-155.
[25] Chen JF, Jing J, Tan H, et al. Lack of association of CYP11B2-344C/T polymorphism with essential hypertension:a meta-analysis[J]. Int J Clin Exp Med, 2015,8(6):9162-9167.
[26] 梁俊青. 离子通道基因SLC12A3多态性和内蒙古地区蒙古族原发性高血压的关联研究[D]. 北京:首都医科大学,2014.
[27] 张铁凝,吕晶玉.WNK4激酶在肾脏离子转运中的作用及机制[J].中华高血压杂志,2015,23(3):227-230.
[28] Ji L, Cai X, Zhang L, et al. Association between polymorphisms in the renin-angiotensin-aldosterone system genes and essential hypertension in the Han Chinese population[J]. PLoS One,2013,8(8):e72701.
[29] 林慧中,陈慧,吴小盈,等. ACE、CYP11B2和α-ADDUCIN基因多态性与福建汉族高血压相关性的分析[J]. 基础医学与临床,2013,33(04):429-433.

备注/Memo

备注/Memo:
作者简介:王月(1990—),在读硕士,主要从事高血压研究。Emall:154284744@qq.com. 通信作者:周健中(1964—),主任医师,硕士,主要从事高血压、冠心病、心力衰竭、心律失常研究。Emall:115155663@qq.com
更新日期/Last Update: 2016-07-25