[1]麦麦提阿卜杜拉·麦麦提敏张玲 瓦沙 曹桂秋 曹佳如 汤宝鹏.48小时快速起搏对老龄犬心房病理性重构的影响[J].心血管病学进展,2024,(2):181.[doi:10.16806/j.cnki.issn.1004-3934.202.02.017]
　Maimaitimin·Maimaitiabudula ZHANG Ling WA Sha CAO Guiqiu CAO Jiaru TANG Baopeng.The Effect Mechanism of 48 hour Rapid Pacing on Atrial Pathological Remodeling in Elder Canine[J].Advances in Cardiovascular Diseases,2024,(2):181.[doi:10.16806/j.cnki.issn.1004-3934.202.02.017]
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48小时快速起搏对老龄犬心房病理性重构的影响()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年2期
页码:
181
栏目:
论著
出版日期:
2024-02-25

文章信息/Info

Title:
The Effect Mechanism of 48 hour Rapid Pacing on Atrial Pathological Remodeling in Elder Canine
作者:
麦麦提阿卜杜拉·麦麦提敏张玲1; 3 瓦沙2 曹桂秋2 曹佳如1; 3 汤宝鹏1; 3
(1新疆医科大学第一附属医院心脏中心起搏电生理科,2.新疆医科大学第五附属医院心血管内科,3.新疆心电生理与心脏重塑重点实验室,乌鲁木齐 830054【
Author(s):
Maimaitimin·Maimaitiabudula1; 2; 3 ZHANG Ling1; 3 WA Sha 2 CAO Guiqiu2 CAO Jiaru1; 3 TANG Baopeng 1; 3
(1.Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054,Xinjiang,China2.Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054,Xinjiang,China3.Department of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054,Xinjiang,China)
关键词:
心房颤动; 老龄; 心房重构
Keywords:
Atrial fibrillation; Ageing; Atrial remodeling
DOI:
10.16806/j.cnki.issn.1004-3934.202.02.017
摘要:
目的 探讨48 h快速起搏对老龄犬心房病理性重构的影响。方法 20只纯种比格犬根据年龄及是否行心内膜起搏分为成年窦律组、老龄窦律组、成年起搏组和老龄起搏组，模型构建成功后行电生理检查、心脏超声检查、心率变异性测定和透射电镜检测以明确快速起搏诱导的老龄犬心房病理性重构。结果 老龄起搏组的PR间期明显延长（P＜0.05），双侧心房和4条肺静脉的有效不应期显著缩短（P＜0.05），心房颤动（房颤）诱发率明显提高（P＜0.05），这些不稳定的心房电生理性质伴随左心房扩张、左心室收缩末期内径增大（P＜0.05），以及心脏功能下降（P＜0.05）。心率变异性P＜0.05），减小副交感神经张力（P＜0.05）。透射电镜显示增龄导致心房肌细胞肌节拉长，线粒体膜和嵴形态明显改变，老龄和高频起搏的双重作用加剧细胞骨架破坏和线粒体裂解。结论 快速心房异位活动显著加剧老龄犬心房电重构、结构重构表征，增加交感神经张力，加速心房肌节破坏和线粒体损伤，促进“房颤致房颤”的恶性循环。
Abstract:
Objective To investigate the effect of 48-hour rapid pacing on the atrial pathological remodeling in the ageing canines. Methods 20 purebred canines were randomized into four groups according to whether receiving the endocardial atrial pacing or the age exactly as the adult sinus group, the elder sinus group, the adult pacing group, the elder pacing group. The electrophysiological properties, the cardiac ultrasound, the heart rate variability and the transmission electron microscope were tested after the establishments of atrial fibrillation(AF) models to figure out the atrial pathological remodeling mediated by rapid pacing. Results The PR intervals were enlarged in the elder pacing group, the bilateral atrial and four pulmonary venous effective refractory period significantly shortened, as well as the elevated AF inducibility (P＜0.05). Such instable electrophysiological parameters were accompanied by the expansive left atrial diameter,the left ventricular systolic diameter and the decreased ejection fraction(P＜0.05). From the results of HRV analysis, we found that rapid pacing can enhance the systemic sympathetic tone and decrease the parasympathetic tone when compared to the ageing groups (P＜0.05). TEM showed that the myotomes of atrial myocytes are elongated, and the morphology of mitochondrial membranes and ridges are significantly changed with the increase of age. In addition, aging combined with rapid pacing could aggravate the cytoskeletal destruction and mitochondrial cleavage under the background of ageing. Conclusion Rapid ectopic activities could significantly facilitate the “AF begets AF” vicious cycle by potentially inducing the electrical and structural remodeling in the ageing canines, increasing the sympathetic tone and accelerating atrial myotome destruction and mitochondrial damage

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备注/Memo

备注/Memo:
收稿日期：2023-06-19 基金项目：新疆维吾尔自治区自然科学基金 (2021D01D16，D01E27)
更新日期/Last Update: 2024-03-29