[1]覃思润 盛喆 陈晨阳 詹耀坤 曹宇.中性粒细胞胞外在冠心病进展中的作用及机制研究[J].心血管病学进展,2023,(12):1088.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.008]
 QIN Sirun,SHENG Zhe,CHEN Chenyang,et al.The Role and Mechanism of Neutrophil Extracellular Traps?n the Progression of Coronary Heart Disease[J].Advances in Cardiovascular Diseases,2023,(12):1088.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.008]
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中性粒细胞胞外在冠心病进展中的作用及机制研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年12期
页码:
1088
栏目:
综述
出版日期:
2023-12-25

文章信息/Info

Title:
The Role and Mechanism of Neutrophil Extracellular Traps?n the Progression of Coronary Heart Disease
作者:
覃思润 盛喆 陈晨阳 詹耀坤 曹宇
(中南大学湘雅三医院心内科,湖南 长沙 410013)
Author(s):
QIN SirunSHENG ZheCHEN ChenyangZHAN YaokunCAO Yu?/html>
?Department of Cardiovascular Medicine,The Third Xiangya Hospital,Central South University ChangshaChangsha 410013HunanChina)
关键词:
中性粒细胞胞外诱捕网冠心病动脉粥样硬化血栓形成
Keywords:
Neutrophil extracellular trapsCoronary artery heart diseaseAtherosclerosisThrombosis
DOI:
10.16806/j.cnki.issn.1004-3934.2023.12.008
摘要:
中性粒细胞是人体免疫系统的主要成分之一,在抵御感染和炎症过程中扮演着重要角色。近年来,研究表明中性粒细胞除了其传统的作用外,还能通过释放胞的形式参与到冠心病等多种疾病的发生和发展中,越来越多的证据表明中性粒细胞胞外在冠状动脉粥样硬化的进程中也起到关键性作用。因此,干预中性粒细胞胞的形成和释放可能是治疗冠状动脉粥样硬化及其并发症的新策略。目前,针对中性粒细胞胞的干预已成为研究的热点,未来,针对中性粒细胞胞的干预可能成为冠心病治疗的新方向之一。现就中性粒细胞胞在冠心病发生发展中的作用机制及其应用前景进行综述。
Abstract:
Neutrophils are one of the main components of the body’s immune system and play an important role in defending against infection and inflammation. In recent years, studies have shown that in addition to its traditional role, neutrophils can also participate in the occurrence and development of a variety of diseases, including coronary heart disease, through the release of extracellular traps, that is, more and more evidence that neutrophils extracellular traps also play a key role in the process of coronary atherosclerosis. Therefore, intervening in the formation and release of neutrophil extracellular traps may be a new strategy for the treatment of coronary atherosclerosis and its complications. At present, the intervention of neutrophil extracellular trap has become a research hotspot, and in the future, the intervention of neutrophil extracellular trap may become one of the new directions of coronary heart disease treatment. This article reviews the mechanism and application prospect of neutrophil extracellular trap in the occurrence and development of coronary heart disease

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备注/Memo

备注/Memo:
收稿日期:2023-03-16基金项目:国家自然科学基金资助项目(82000300)
更新日期/Last Update: 2024-01-19