[1]原达 朱国斌.血小板P选择素及CD40/CD40L在动脉粥样硬化中的研究进展[J].心血管病学进展,2021,(10):928.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.016]
 YUAN Da,ZHU Guobin.Research Progress of Platelet-Related P-Selectin and?D40L Pro-Inflammatory Effects in Atherosclerosis[J].Advances in Cardiovascular Diseases,2021,(10):928.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.016]
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血小板P选择素及CD40/CD40L在动脉粥样硬化中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年10期
页码:
928
栏目:
综述
出版日期:
2021-10-25

文章信息/Info

Title:
Research Progress of Platelet-Related P-Selectin and?D40L Pro-Inflammatory Effects in Atherosclerosis
作者:
原达1 朱国斌 2
(1.山西医科大学研究生院,山西 太原 030001;2.山西医科大学附属第二临床医学院心内科,山西 太原 030001)
Author(s):
YUAN Da1ZHU Guobin2
?1.Shanxi Medical University Graduate SchoolTaiyuan 030001ShanxiChina2.Department of CardiologySecond Medical College of Shanxi Medical UniversityTaiyuan 030001ShanxiChina)
关键词:
血小板动脉粥样硬化P选择素CD40/CD40L炎症
Keywords:
PlateleAtherosclerosisP-selectinCD40/CD40LInflammatory
DOI:
10.16806/j.cnki.issn.1004-3934.2021.10.016
摘要:
血小板是炎症反应的关键介质,活化的血小板可表达P选择素、CD40及CD40L,激活内皮细胞且促进白细胞的募集和活化,加速动脉粥样硬化病变。现就近年来血小板表面P选择素、CD40/CD40L在动脉粥样硬化中的促炎作用及其相关防治靶点的研究进展做一综述。
Abstract:
Platelets?arerecognized?as key?mediators?of?inflammation.Activated platelets express P-selectin and CD40/CD40ligand on the membrane surface,then activate endothelial cells and promote the recruitment and activation of white blood cells,finally accelerate the progression of atherosclerosis. This article summarizes the research progress of platelet-related P-selectin and CD40/CD40L in atherosclerosis and related prevention and treatment targets in recent years.

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更新日期/Last Update: 2021-12-02