[1]刘家汝 关秀茹.Nrf2/ARE信号通路在动脉粥样硬化中的研究新进展[J].心血管病学进展,2020,(8):859-862.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.019]
 LIU Jiaru,GUAN Xiuru.Nrf2/ARE Signaling Pathway in Atherosclerosis[J].Advances in Cardiovascular Diseases,2020,(8):859-862.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.019]
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Nrf2/ARE信号通路在动脉粥样硬化中的研究新进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年8期
页码:
859-862
栏目:
综述
出版日期:
2020-08-25

文章信息/Info

Title:
Nrf2/ARE Signaling Pathway in Atherosclerosis
作者:
刘家汝 关秀茹
(哈尔滨医科大学附属第一医院检验科,黑龙江 哈尔滨 150001)
Author(s):
LIU JiaruGUAN Xiuru
(Department of Clinical Laboratory The First Affiliated Hospital of Harbin Medical University Harbin 150001 Heilongjiang China)
关键词:
动脉粥样硬化核因子相关因子2氧化应激
Keywords:
Atherosclerosis Nuclear factor related factor 2 Oxidative stress
DOI:
10.16806/j.cnki.issn.1004-3934.2020.08.019
摘要:
动脉粥样硬化是一种综合脂质代谢紊乱和炎症的慢性心血管疾病。由于Nrf2/ARE信号通路是一种对氧化应激极为敏感的信号轴,具有抗氧化活性,参与调节细胞稳态、炎症因子释放及脂质形成等,因此Nrf2/ARE信号通路与动脉血管内皮损伤和泡沫细胞形成密切相关,并且对动脉粥样硬化具有双重调控效应。本文就Nrf2/ARE信号通路在动脉粥样硬化中的作用进行综述,旨在探寻防治动脉粥样硬化全新的分子靶点。
Abstract:
Atherosclerosis is a chronic cardiovascular disease that combines lipid metabolism disorder and inflammatory response. Because the Nrf2/ARE signaling pathway is a signal axis which is extremely sensitive to oxidative stress and has antioxidant activity, it is involved in regulating cell homeostasis, inflammatory factors release and lipid formation. Therefore, Nrf2/ARE signaling pathway is closely related to the formation of endothelial cells and foam cells, and has dual regulatory effects on atherosclerosis. This article reviews the role of Nrf2/ARE signaling pathway in atherosclerosis in order to find a new molecular target for the prevention and treatment of atherosclerosis.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81672084)
通信作者:关秀茹,E-mail:gxr0451@ sina.com
收稿日期:2020-01-31
更新日期/Last Update: 2020-11-02