[1]亢玉,综述,张庆,等.二尖瓣瓣叶在功能性二尖瓣反流发生机制中的角色[J].心血管病学进展,2016,(4):376-379.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.013]
 KANG Yu,ZHANG Qing.Role of Mitral Leaflets in Pathogenesis of Functional Mitral Regurgitation[J].Advances in Cardiovascular Diseases,2016,(4):376-379.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.013]
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二尖瓣瓣叶在功能性二尖瓣反流发生机制中的角色()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年4期
页码:
376-379
栏目:
综述
出版日期:
2016-08-15

文章信息/Info

Title:
Role of Mitral Leaflets in Pathogenesis of Functional Mitral Regurgitation
作者:
亢玉综述张庆审校
四川大学华西医院心内科,四川 成都 610041
Author(s):
KANG Yu ZHANG Qing
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
关键词:
心力衰竭 功能性二尖瓣反流 二尖瓣瓣叶
Keywords:
Heart failure Functional mitral regurgitation Mitral valve leaflets
分类号:
R542.5+1
DOI:
10.16806/j.cnki.issn.1004-3934.2016.04.013
文献标志码:
A
摘要:
功能性二尖瓣反流是心力衰竭的常见并发症,是影响心力衰竭患者预后的独立危险因素。其发生主要是因左心室重构导致作用于二尖瓣瓣叶的一对反向作用力即牵拉力和关闭力的失衡,以及二尖瓣瓣环的扩张形变所致,而其中二尖瓣瓣叶曾被认为具有正常的结构与功能,仅作为“被动参与者”。近期国内外的研究发现二尖瓣瓣叶也主动参与了该过程,不仅有生物化学水平的改变,而且在表观形态上呈现瓣叶总面积的增加。由于这种适应性瓣叶增大相对于左心室和二尖瓣瓣环重构的比值不同,而表现为不同程度的功能性二尖瓣反流。
Abstract:
Functional mitral regurgitation(FMR)is a common complication of heart failure, and also an independent risk factor of poor prognosis. The imbalance of closing and tethering forces due to left ventricular remodeling and mitral annular dilation contributes mainly to the occurrence of FMR, where the mitral valve leaflets used to be considered as passive participants with normal structure and function. However, recent studies have revealed that mitral valve leaflets are active participants in the pathogenesis of FMR, which not only display adaptive biochemical changes, but also demonstrate morphological enlargement. The adaptive enlargement in mitral valve leaflets relative to ventricular and mitral annular remodeling may become another contributor to the degree of FMR in patients with heart failure.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81470508) 作者简介:亢玉(1990—),在读硕士,主要从事心力衰竭的基础与临床、心脏功能的超声研究。Email:378809973@qq.com 通信作者:张庆(1968—),教授,博士生导师,博士,主要从事心力衰竭的基础与临床、心脏功能的超声研究。Email:qzhang2000cn@yahoo.com
更新日期/Last Update: 2016-07-25