[1]刘嘉昕 王语乾 李公信.药物治疗残余胆固醇的临床研究新进展[J].心血管病学进展,2025,(1):59.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.014]
 LIU Jiaxin,WANG Yuqian,LI Gongxin.Pharmacotherapy for Remnant Cholesterol[J].Advances in Cardiovascular Diseases,2025,(1):59.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.014]
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药物治疗残余胆固醇的临床研究新进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年1期
页码:
59
栏目:
综述
出版日期:
2025-01-25

文章信息/Info

Title:
Pharmacotherapy for Remnant Cholesterol
作者:
刘嘉昕 王语乾 李公信
(南方医科大学珠江医院心血管内科,广东 广州510220)
Author(s):
LIU Jiaxin WANG YuqianLI Gongxin
(Department of Cardiology, Zhujiang Hospital of Southern Medical University,Guangzhou 510220,Guangdong,China)
关键词:
残余胆固醇动脉粥样硬化高血压糖尿病药物治疗
Keywords:
Remnant cholesterolAtherosclerosisHypertensionDiabetesPharmacotherapy
DOI:
10.16806/j.cnki.issn.1004-3934.2025.01.014
摘要:
残余胆固醇(RC)主要由富含甘油三酯脂蛋白中的胆固醇组成。研究表明,RC的升高与动脉粥样硬化、高血压、糖尿病等多种疾病密切相关,前蛋白转化酶枯草溶菌素9抑制剂等药物能不同程度地降低RC并降低心血管疾病风险。伴随着越来越多的临床获益证据,RC未来有望成为心血管疾病管理中的重要治疗靶点。现综述RC的形成、代谢及其主要危害,重点探讨多种药物在降低RC水平方面的作用机制及临床应用。
Abstract:
Remnant cholesterol(RC) is primarily composed of cholesterol in triglyceride-rich lipoproteins. Research has shown that elevated RC levels are closely associated with diseases such as atherosclerosis ,hypertension and diabetes. Drugs such as proprotein convertase subtilisin/kexin type 9 inhibitors can reduce RC to varying degrees and lower cardiovascular disease risk. With increasing clinical evidence of their benefits,RC is likely to become an important therapeutic target in the management of cardiovascular diseases in the future. This article reviews the formation,metabolism and major hazards of RC,focusing on the mechanisms and clinical applications of various drugs in lowering RC levels.

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