[1]马廷琼 雷蕾 王炎.尼非卡兰在心房颤动中的应用进展[J].心血管病学进展,2024,(8):677.[doi:10.16806/j.cnki.issn.1004-3934.2024.08.002]
 MA Tingqiong,LEI Lei,WANG Yan.Application of Nifekalant in Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2024,(8):677.[doi:10.16806/j.cnki.issn.1004-3934.2024.08.002]
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尼非卡兰在心房颤动中的应用进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年8期
页码:
677
栏目:
综述
出版日期:
2024-08-25

文章信息/Info

Title:
Application of Nifekalant in Atrial Fibrillation
作者:
马廷琼 雷蕾 王炎
(华中科技大学同济医学院附属同济医院心血管内科,湖北 武汉 430030)
Author(s):
MA TingqiongLEI Lei WANG Yan
(Division of Cardiology and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,Hubei,China)
关键词:
心房颤动尼非卡兰 射频导管消融术
Keywords:
Atrial fibrillation Nifekalant Radiofrequency catheter ablation
DOI:
10.16806/j.cnki.issn.1004-3934.2024.08.002
摘要:
心房颤动是最常见的心律失常之一,与卒中等密切相关。恢复窦性心律对心房颤动管理尤其重要,临床常用的复律手段包括药物复律、电复律及射频消融或其联合使用等。胺碘酮是最常用的抗心律失常药,但其可引起多种心外副作用,临床应用受限。尼非卡兰是一种纯钾离子通道阻滞剂,主要用于室性心律失常,近年来相关研究发现尼非卡兰对心房颤动也具有较好的疗效,但应用较少。故现旨在总结已有临床经验,更好地指导尼非卡兰在心房颤动中的应用。
Abstract:
Atrial fibrillation is one of the most common cardiac arrhythmias and is closely associated with stroke. Restoring sinus rhythm is particularly important for the management of atrial fibrillation, with clinical methods commonly including pharmacological cardioversion, electrical cardioversion, and radiofrequency ablation, or a combination of these approaches. Amiodarone is the most frequently used antiarrhythmic drug, but it can cause a variety of extracardiac side effects, limiting its clinical application. Nifekalant is a pure potassium ion channel blocker, primarily used for ventricular arrhythmias. Recent studies have suggested that nifekalant also has good efficacy for atrial fibrillation, although it is less commonly used. Therefore, the aim here is to summarize existing clinical experience to better guide the application of nifekalant in the treatment of atrial fibrillation

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