[1]陈坤 王聪颖 孙鑫 李少杰 谷剑 陈淑霞 王立立.Toll样受体4信号通路在心力衰竭中的应用价值[J].心血管病学进展,2024,(5):438.[doi:10.16806/j.cnki.issn.1004-3934.2024.05.013]
 CHEN Kun,WANG Congying,SUN Xin,et al.The Application Value of Toll-Like Receptor 4 Signaling Pathway in Heart Failure[J].Advances in Cardiovascular Diseases,2024,(5):438.[doi:10.16806/j.cnki.issn.1004-3934.2024.05.013]
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Toll样受体4信号通路在心力衰竭中的应用价值()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年5期
页码:
438
栏目:
综述
出版日期:
2024-05-25

文章信息/Info

Title:
The Application Value of Toll-Like Receptor 4 Signaling Pathway in Heart Failure
作者:
陈坤1 王聪颖1 孙鑫1 李少杰1 谷剑12 陈淑霞12 王立立2
(1.河北北方学院研究生院,河北 张家口 075000;2.河北省人民医院心血管内科,河北 石家庄 050051)
Author(s):
CHEN Kun1WANG Congying1SUN Xin1LI Shaojie1GU Jian12CHEN Shuxia12WANG Lili2
(1.Granduate School of Hebei North College,Zhangjiakou 075000,Hebei,China;2.Department of Cardiovascular Medicine,Hebei Provincial Peoples Hospital,Shijiazhuang 050051,Hebei,China)
关键词:
Toll样受体4心力衰竭疾病预后药物靶点预测价值
Keywords:
Toll-like receptor 4 Heart failure Prognosis of the disease Drug targetPredicted value
DOI:
10.16806/j.cnki.issn.1004-3934.2024.05.013
摘要:
心力衰竭是全球发病率最高的疾病之一,在心力衰竭及其合并症的发生和发展过程中炎症机制起着至关重要的作用。大量研究表明Toll样受体4信号通路可通过介导不同的炎症因子,对心肌造成损害,因此近期发现Toll样受体4信号通路可用于预测心力衰竭及其合并症病情的严重程度及预后,同时也可作为许多新型抗心力衰竭药物的靶点,改善症状,使心力衰竭患者获益。现就Toll样受体4信号通路在心力衰竭中上述两方面的应用价值做一综述。
Abstract:
Heart failure is one of the most prevalent diseases in the world,and inflammation plays a crucial role in the occurrence and development of heart failure and its comorbidities. A large number of studies have shown that the Toll-like receptor 4 signaling pathway can cause damage to the myocardium by mediating different inflammatory factors. Therefore,it has recently been found that the Toll-like receptor 4 signaling pathwa y can be used to predict the severity and prognosis of heart failure and its comorbidities,and at the same time,it can also be used as a target for many new anti-heart failure drugs to improve symptoms and benefit patients with heart failure. This article reviews the application value of the Toll-like receptor 4 signaling pathway in the above two aspects in heart failure.

参考文献/References:

[1] Savarese G,Becher PM,Lund LH,et al. Global burden of heart failure:a comprehensive and updated review of epidemiology[J]. Cardiovasc Res,2023,118(17):3272-3287.

[2] 李晓洁,许泽鹏,黄玉婷,等. Toll样受体4信号通路在糖尿病视网膜病变中的研究进展[J].中国中医眼科杂志,2023,33(1):73-79.

[3] Deguchi A,Maru Y. Inflammation-associated premetastatic niche formation[J]. Inflamm Regen,2022,42(1):22.

[4] Zhang S,Chen F,Zhai F,et al. Role of HMGB1/TLR4 and IL-1β/IL-1R1 signaling pathways in epilepsy[J]. Front Neurol,2022,13:904225.

[5] Sumneang N,Apaijai N,Chattipakorn SC,et al. Myeloid differentiation factor 2 in the heart:Bench to bedside evidence for potential clinical benefits?[J]. Pharmacol Res,2021,163:105239.

[6] Ciesielska A,Matyjek M,Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling[J]. Cell Mol Life Sci,2021,78(4):1233-1261.

[7] Xiao Z,Kong B,Yang H,et al. Key Player in cardiac hypertrophy,emphasizing the role of Toll-like receptor 4[J]. Front Cardiovasc Med,2020,7:579036.

[8] Zhang Y,Liang X,Bao X,et al. Toll-like receptor 4 (TLR4) inhibitors:current research and prospective[J]. Eur J Med Chem,2022,235:114291.

[9] 梁魏昉. 心力衰竭患者TLR4/NF-κB信号通路、vWF、D-二聚体水平变化及其与心力衰竭程度、LVEF的相关性分析[J]. 中西医结合心脑血管病杂志,2022,20(5):887-892.

[10] 文仙仙,张娜,王兴兴,等. Toll样受体4信号通路对慢性心力衰竭患者心血管事件的预测[J].心肺血管病杂志,2023,42(6):547-552.

[11] 章敬玉,李志华,陈健. 上呼吸道感染伴急性心力衰竭患者外周血HMGB1和TLR4水平与心脏功能的关系[J]. 热带医学杂志,2023,23(7):964-968.

[12] 王国玉,王淼,李彤,等. 慢性心力衰竭合并社区获得性肺炎患者血清TLR4表达及与PCT、NT-proBNP、氧化应激指标的相关性分析[J]. 中国现代医学杂志,2023,33(7):60-65.

[13] Tamargo J,Caballero R,Delpon E. New drugs in preclinical and early stage clinical development in the treatment of heart failure[J]. Expert Opin Investig Drugs,2019,28(1):51-71.

[14] Dutka M,Bobinski R,Ulman-Wlodarz I,et al. Sodium glucose cotransporter 2 inhibitors:mechanisms of action in heart failure[J]. Heart Fail Rev,2021,26(3):603-622.

[15] Yang J,Wise L,Fukuchi KI. TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer’s disease[J]. Front Immunol,2020,11:724.

[16] Byrne NJ,Matsumura N,Maayah ZH,et al. Empagliflozin blunts worsening cardiac dysfunction associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3) inflammasome activation in heart failure[J]. Circ Heart Fail,2020,13(1):e6277.

[17] Eiringhaus J,Wünsche CM,Tirilomis P,et al. Sacubitrilat reduces pro-arrhythmogenic sarcoplasmic reticulum Ca2+ leak in human ventricular cardiomyocytes of patients with end-stage heart failure[J]. ESC Heart Fail ,2020,7(5):2992-3002.

[18] Koyani CN,Plastira I,Sourij H,et al. Empagliflozin protects heart from inflammation and energy depletion via AMPK activation[J]. Pharmacol Res,2020,158:104870.

[19] Mustroph J,Wagemann O,Lucht CM,et al. Empagliflozin reduces Ca/calmodulin-dependent kinase Ⅱ activity in isolated ventricular cardiomyocytes[J]. ESC Heart Fail,2018,5(4):642-648.

[20] Kang H,Zhang J,Zhang X,et al. Effects of sacubitril/valsartan in patients with heart failure and chronic kidney disease:a meta-analysis[J]. Eur J Pharmacol,2020,884:173444.

[21] Shen J,Fan Z,Sun G,et al. Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3?induced pyroptosis via the TAK1/JNK signaling pathway[J]. Mol Med Rep,2021,24(3):676.

[22] Bunsawat K,Ratchford SM,Alpenglow JK,et al. Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction[J]. J Appl Physiol (1985),2021,130(1):256-268.

[23] Luo X,Hu Y,He S,et al. Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation[J]. Arch Biochem Biophys,2019,671:203-209.

[24] Fu Z,Mui D,Zhu H,et al. Exenatide inhibits NF-κB and attenuates ER stress in diabetic cardiomyocyte models[J]. Aging (Albany NY),2020,12(9):8640-8651.

[25] Ma G,Liu Y,Wang Y,et al. Liraglutide reduces hyperglycemia-induced cardiomyocyte death through activating glucagon-like peptide 1 receptor and targeting AMPK pathway[J]. J Recept Signal Transduct Res,2020,40(2):133-140.

[26] Meng J,Zhang W,Wang C,et al. The dipeptidyl peptidase (DPP)-4 inhibitor trelagliptin inhibits IL-1β-induced endothelial inflammation and monocytes attachment[J]. Int Immunopharmacol,2020,89(Pt B):106996.

[27] Baylan U,Korn A,Emmens RW,et al. Liraglutide treatment attenuates inflammation markers in the cardiac,cerebral and renal microvasculature in streptozotocin-induced diabetic rats[J]. Eur J Clin Invest,2022,52(9):e13807.

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更新日期/Last Update: 2024-06-28