[1]马艺萍 袁玉娟 艾力菲热·艾海提 马清玉 阿卜拉江·艾合麦提 穆叶赛·尼加提.内皮细胞微粒miRNA在急性心肌梗死中的研究进展[J].心血管病学进展,2023,(6):557.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.017]
　Ma Yiping,Yuan Yujuan,Ailifeire·Aihaiti,et al.Endothelial Microparticles miRNA in Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2023,(6):557.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.017]
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内皮细胞微粒miRNA在急性心肌梗死中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年6期
页码:
557
栏目:
综述
出版日期:
2023-06-25

文章信息/Info

Title:
Endothelial Microparticles miRNA in Acute Myocardial Infarction
作者:
马艺萍1 袁玉娟1 艾力菲热·艾海提 1 马清玉2 阿卜拉江·艾合麦提1 穆叶赛·尼加提3
(1.新疆医科大学,新疆 乌鲁木齐 830000;2.石河子大学,新疆 石河子 832003;3.新疆维吾尔自治区人民医院,新疆 乌鲁木齐 830000)
Author(s):
Ma Yiping1; Yuan Yujuan1; Ailifeire·Aihaiti1; Ma Qingyu2; Abulajiang·Aihemaiti1; Muyesai·Nijiati3
Xinjiang Medical University ,Urumqi 830000,Xinjiang,China; 2.Shihezi University,Shihezi 832003,Xinjiang,China; 3.People’s Hospital of Xinjiang Uygur Autonomous Region ,Urumqi 830000,Xinjiang,China)
关键词:
内皮细胞微粒; miRNA; 急性心肌梗死
Keywords:
Endothelial microparticles;  miRNA;  Acute myocardial infarction
DOI:
10.16806/j.cnki.issn.1004-3934.2023.06.017
摘要:
急性心肌梗死（AMI）是世界范围内死亡的主要原因，及早发现该疾病是风险管理和有效治疗的关键目标。内皮细胞微粒（EMPs）是内皮细胞脱落的细胞外小囊泡，可以作为携带细胞因子、信号蛋白、微小RNA（miRNA）等物质远距离传输生物学信息的载体，在调节内皮细胞功能、炎症反应、氧化应激和血管生成中起关键作用。miRNA是一种含有约22个核苷酸的短链、内源性、非编码RNA，与靶mRNA特异性结合，导致翻译阻遏，调节转录后基因的表达，从而参与细胞的生长分化等病理生理过程。近年来研究显示EMPs可以借助miRNA调节多种信号通路，在AMI的发生、发展中具有重要作用，在诊断和治疗方面具有较大应用前景。现针对EMPs miRNA在AMI中的研究进展进行简要概述。
Abstract:
Acute myocardial infarction (AMI) is the leading cause of death worldwide,and early detection of this disease is a key goal for risk management and effective treatment. Endothelial microparticles (EMPs) are exfoliated extracellular vesicles of endothelial cells,which can carry cytokines,signaling proteins,microRNA (miRNA) and other substances to transmit biological information over long distance,and play a key role in regulating endothelial cell function,inflammation,oxidative stress and angiogenesis. miRNA is a kind of short chain,endogenous and non-coding RNA containing about 22 nucleotides. It specifically binds to target mRNA,leads to translation repression,regulates the expression of post-transcribed genes,and thus participates in the pathophysiological processes of cell growth and differentiation. In recent years,studies have shown that EMPs can regulate a variety of signaling pathways with the help of miRNA,which plays an important role in the occurrence and development of AMI and has great application prospects in diagnosis and treatment. This paper will briefly review the research progress of EMPs miRNA in AMI

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更新日期/Last Update: 2023-07-21