[1]陈纪元 陆泓雨 贺子熠 韩江莉.冠心病合并慢性肾脏病患者P2Y12受体拮抗剂治疗进展[J].心血管病学进展,2022,(7):582-585,614.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
 CHEN Jiyuan,LU Hongyu,HE Ziyi,et al.P2Y12 Antagonists for Patients with Chronic Kidney Diseases and Coronary Heart Diseases[J].Advances in Cardiovascular Diseases,2022,(7):582-585,614.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
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冠心病合并慢性肾脏病患者P2Y12受体拮抗剂治疗进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年7期
页码:
582-585,614
栏目:
综述
出版日期:
2022-07-25

文章信息/Info

Title:
P2Y12 Antagonists for Patients with Chronic Kidney Diseases and Coronary Heart Diseases
文章编号:
202203074
作者:
陈纪元 陆泓雨 贺子熠 韩江莉
(北京大学第三医院心内科,北京 100191 )
Author(s):
CHEN Jiyuan LU Hongyu HE Ziyi HAN Jiangli
(Department of Cardiology,Peking University Third Hospital,Beijing 100191,China)
关键词:
冠心病慢性肾脏病抗血小板治疗急性冠状动脉综合征
Keywords:
Coronary heart diseaseChronic kidney diseaseAntiplatelet therapy Acute coronary syndrome
DOI:
10.16806/j.cnki.issn.1004-3934.2022.07.000
摘要:
冠心病是慢性肾脏病患者的主要死亡原因。阿司匹林联合P2Y12受体拮抗剂的双联抗血小板治疗是冠心病管理的基石。冠心病合并慢性肾脏病患者兼具高血栓风险和高出血风险,因此双联抗血小板治疗面临严峻挑战。既往大多数冠心病临床研究常将严重的慢性肾脏病列入排除标准,因而临床医生管理冠心病合并慢性肾脏病患者时可参考的循证医学证据有限。现对近期冠心病合并慢性肾脏病患者应用P2Y12受体拮抗剂治疗相关研究进行综述,为临床医生选择P2Y12受体拮抗剂种类、剂量和疗程提供依据。
Abstract:
Coronary heart disease(C HD) is the leading cause of deaths in patient with chronic kidney disease(CKD). Dual antiplatelet therapy with aspirin and P2Y12 antagonists is regarded as the cornerstone in respect of C HD management. Patients with CHD and CKD have high risk of thrombosis and hemorrhage,so the dual antiplatelet therapy is facing severe challenges. Nevertheless,CKD patients are usually excluded in most clinical experiments. As a result,evidence-based therapies are limited. This article reviews the recent research on the use of P2Y12 receptor antagonists in patients with CHD and CKD,so as to provide a basis for clinicians to select the type,dose and course of treatment of P2Y12 receptor antagonists.

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更新日期/Last Update: 2022-08-22