[1]郑声伟 庄梅.心房颤动患者抗凝治疗对相关认知功能影响的最新进展[J].心血管病学进展,2022,(5):411-414.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.007]
 ZHENG Shengwei,ZHUANG Mei.Influence of Anticoagulation Therapy on Related Cognitive Function in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2022,(5):411-414.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.007]
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心房颤动患者抗凝治疗对相关认知功能影响的最新进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年5期
页码:
411-414
栏目:
出版日期:
2022-05-25

文章信息/Info

Title:
Influence of Anticoagulation Therapy on Related Cognitive Function in Patients with Atrial Fibrillation
作者:
郑声伟1 庄梅2
(1.贵州医科大学研究生院,贵州 贵阳 550025;2.贵州医科大学附属医院心内科,贵州 贵阳 550025)
Author(s):
ZHENG Shengwei1ZHUANG Mei2
(1.Guizhou Medical University Graduate SchoolGuiyang 550025 GuizhouChina; 2.Department of Cardiology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550025 ,Guizhou,China)
关键词:
心房颤动抗凝剂认知障碍痴呆
Keywords:
Atrial fibrillationAnticoagulantsCognitive disorderDementia
DOI:
10.16806/j.cnki.issn.1004-3934.2022.05.007
摘要:
心房颤动通过多种途径影响认知功能,尤其是心房颤动相关卒中所致认知障碍的不良后果,严重影响患者的生活质量,目前尚缺乏可靠的预防和治疗策略。抗凝治疗是心房颤动患者预防卒中治疗的基石,华法林和新型口服抗凝药物在房颤患者中对认知障碍终点作用的比较在近年备受关注,部分潜在益处和风险的证据在研究中展现出来。现就抗凝治疗对心房颤动相关认知功能影响的最新进展做相关综述。
Abstract:
Atrial fibrillation affects cognitive function through multiple pathways,especially the adverse consequences of cognitive disorder caused by atrial fibrillation-related stroke,which severely affecting patients’ quality of life,but there is still a lack of reliable prevention and treatment strategies. Anticoagulation is the cornerstone of stroke prevention in atrial fibrillation patients . The comparison of the effects of warfarin and new oral anticoagulants on cognitive disorder endpoints in patients with atrial fibrillation has attracted much attention in recent years,and some evidence of potential benefits and risks has been shown in the research. This paper reviews the latest progress of anticoagulant therapy on cognitive function related to atrial fibrillation.

参考文献/References:

[1] Hindricks G,Potpara T,Dagres N,et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery(EACTS):The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology(ESC) Developed with the special contribution of the European Heart Rhythm Association(EHRA) of the ESC[J]. Eur Heart J,2021,42(5):373-498.

[2] Yuan L,Zhang X,Guo N,et al. Prevalence of cognitive impairment in Chinese older inpatients and its relationship with 1-year adverse health outcomes:a multi-center cohort study[J]. BMC Geriatr,2021,21(1):595.

[3] Chen LY,Norby FL,Gottesman RF,et al. Association of atrial fibrillation with cognitive decline and dementia over 20?years:the ARIC-NCS(Atherosclerosis Risk in Communities Neurocognitive Study)[J]. J Am Heart Assoc,2018,7(6):e007301.

[4] Zuin M,Roncon L,Passaro A,et al. Risk of dementia in patients with atrial fibrillation:short versus long follow-up. A systematic review and meta-analysis[J]. Int J Geriatr Psychiatry,2021,36(10):1488-1500.

[5] Wang X,Wang Z,Yan X,et al. Radiofrequency and cryoballoon ablation improve cognitive function in patients with atrial fibrillation[J]. Medicine(Baltimore),2021,100(32):e26914.

[6] Mohanty S,Mohanty P,Trivedi C,et al. Impact of oral anticoagulation therapy versus left atrial appendage occlusion on cognitive function and quality of life in patients with atrial fibrillation[J]. J Am Heart Assoc,2021,10(9):e019664.

[7] Mailhot T,Mcmanus DD,Waring ME,et al. Frailty,cognitive impairment,and anticoagulation among older adults with nonvalvular atrial fibrillation[J]. J Am Geriatr Soc,2020,68(12):2778-2786.

[8] Ding M,Fratiglioni L,Johnell K,et al. Atrial fibrillation,antithrombotic treatment,and cognitive aging:a population-based study[J]. Neurology,2018,91(19):e1732-e1740.

[9] Qu Y,Zhuo L,Li N,et al. Prevalence of post-stroke cognitive impairment in china:a community-based,cross-sectional study[J]. PLoS One,2015,10(4):e0122864.

[10] Moazzami K,Shao IY,Chen LY,et al. Atrial fibrillation,brain volumes,and subclinical cerebrovascular disease(from the Atherosclerosis Risk in Communities Neurocognitive Study[ARIC-NCS])[J]. Am J Cardiol,2020,125(2):222-228.

[11] Grossmann K. Direct oral anticoagulants:a new therapy against Alzheimer’s disease?[J]. Neural Regen Res,2021,16(8):1556-1557.

[12] Bian Z,Liu X,Feng T,et al. Protective effect of rivaroxaban against amyloid pathology and neuroinflammation through inhibiting PAR-1 and PAR-2 in Alzheimer’s disease mice[J]. J Alzheimers Dis,2022,86(1):111-123.

[13] Cortes-Canteli M,Kruyer A,Fernandez-Nueda I,et al. Long-term dabigatran treatment delays Alzheimer’s disease pathogenesis in the TgCRND8?mouse model[J]. J Am Coll Cardiol,2019,74(15):1910-1923.

[14] Conen D,Rodondi N,Müller A,et al. Relationships of overt and silent brain lesions with cognitive function in patients with atrial fibrillation[J]. J Am Coll Cardiol,2019,73(9):989-999.

[15] Zhong HH,Qu JF,Xiao WM,et al. Severity of lesions involving the cortical cholinergic pathways may be associated with cognitive impairment in subacute ischemic stroke[J]. Front Neurol,2021,12:606897.

[16] Guidoux C,Meseguer E,Ong E,et al. Twelve-month outcome in patients with stroke and atrial fibrillation not suitable to oral anticoagulant strategy:the WATCH-AF registry[J]. Open Heart,2019,6(2):e001187.

[17] Li L,Wu DH,Li HQ,et al. Association of cerebral microbleeds with cognitive decline:a longitudinal study[J]. J Alzheimers Dis,2020,75(2):571-579.

[18] Li X,Yuan J,Qin W,et al. Cerebral microbleeds are associated with impairments in executive function and processing speed[J]. J Alzheimers Dis,2021,81(1):255-262.

[19] Ahn SJ,Anrather J,Nishimura N,et al. Diverse inflammatory response after cerebral microbleeds includes coordinated microglial migration and proliferation[J]. Stroke,2018,49(7):1719-1726.

[20] Cheng Y,Wang Y,Song Q,et al. Use of anticoagulant therapy and cerebral microbleeds:a systematic review and meta-analysis[J]. J Neurol,2021,268(5):1666-1679.

[21] Mongkhon P,Fanning L,Lau WCY,et al. Oral anticoagulant and reduced risk of dementia in patients with atrial fibrillation:a population-based cohort study[J]. Heart Rhythm,2020,17(5 Pt A):706-713.

[22] Madhavan M,Hu TY,Gersh BJ,et al. Efficacy of warfarin anticoagulation and incident dementia in a community-based cohort of atrial fibrillation[J]. Mayo Clin Proc,2018,93(2):145-154.

[23] Petroni R,Magnano R,Pezzi L,et al. Analysis of risk factors independently associated with cognitive impairment in patients with permanent atrial fibrillation:a cross-sectional observational study[J]. J Stroke Cerebrovasc Dis,2020,29(8):104895.

[24] Jankowska-Polańska B,Katarzyna L,Lidia A,et al. Cognitive function and adherence to anticoagulation treatment in patients with atrial fibrillation[J]. J Geriatr Cardiol,2016,13(7):559-565.

[25] Cadogan SL,Powell E,Wing K,et al. Anticoagulant prescribing for atrial fibrillation and risk of incident dementia[J]. Heart,2021,107(23):1898-1904.

[26] Chen N,Lutsey PL,Maclehose RF,et al. Association of oral anticoagulant type with risk of dementia among patients with nonvalvular atrial fibrillation[J]. J Am Heart Assoc,2018,7(21):e009561.

[27] Kim D,Yang PS,Jang E,et al. Association of anticoagulant therapy with risk of dementia among patients with atrial fibrillation[J]. Europace,2021,23(2):184-195.

[28] S?gaard M,Skj?th F,Jensen M,et al. Nonvitamin K antagonist oral anticoagulants versus warfarin in atrial fibrillation patients and risk of dementia:a nationwide propensity-weighted cohort study[J]. J Am Heart Assoc,2019,8(11):e011358.

[29] Bauersachs R,Zannad F. Rivaroxaban:a new treatment paradigm in the setting of vascular protection?[J]. Thromb Haemost,2018,118(S 01):S12-S22.

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更新日期/Last Update: 2022-06-30