[1]肖明瑛 苏冠华.PCSK9抑制剂多效性研究进展[J].心血管病学进展,2022,(2):124.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.008]
 XIAO MingyingSU Guanhua.Pleiotropic Effects of PCSK9 Inhibitors[J].Advances in Cardiovascular Diseases,2022,(2):124.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.008]
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PCSK9抑制剂多效性研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年2期
页码:
124
栏目:
综述
出版日期:
2022-02-25

文章信息/Info

Title:
Pleiotropic Effects of PCSK9 Inhibitors
作者:
肖明瑛1 苏冠华2
(1.华中科技大学同济医学院第一临床学院,湖北 武汉 430022;2.华中科技大学同济医学院附属协和医院心血管内科,湖北 武汉 430022)
Author(s):
XIAO Mingying1SU Guanhua2
(1.The First Clinical School,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China; 2.Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China)
关键词:
多效性前蛋白转化酶枯草溶菌素9炎症动脉粥样硬化血小板
Keywords:
Pleiotropic effectsProprotein convertase subtilisin/kexin type 9InflammationAtherosclerosisPlatelet
DOI:
10.16806/j.cnki.issn.1004-3934.2022.02.008
摘要:
前蛋白转化酶枯草溶菌素9(PCSK9)是一种主要由肝脏合成的分泌型丝氨酸蛋白酶,通过结合低密度脂蛋白受体促进其降解,从而减少低密度脂蛋白胆固醇的清除。PCSK9抑制剂是一种新型降脂药,主要通过与PCSK9结合而抑制其上述生理作用。近年来,越来越多的研究表明PCSK9抑制剂除降脂之外还有许多其他的作用。现主要针对其降脂之外的抗炎、抗动脉粥样硬化、抗血小板聚集和抗血栓形成、抗肿瘤等作用进行综述。
Abstract:
Proprotein convertase subtilisin/kexin type 9(PCSK9),a secretory serine protease mainly synthesized by the liver,promotes the degradation of low density lipoprotein receptor after binding to the receptor,and reduces the clearance of low-density lipoprotein cholesterol. PCSK9 inhibitors constitute a new class of lipid-lowering drugs,of which main mechanism is binding to PCSK9 and inhibiting the above-mentioned physiological effects. Recently,abundant evidence has elucidated the pleiotropic effects of PCSK9 inhibitors beyond lipid-lowering. This review focuses on the pleiotropic effects of PCSK9 inhibitors independent of lipid-lowering,such as anti-inflammatory effect,anti-atherosclerotic effect,anti-platelet aggregation effect,anti-thrombotic effect and antineoplastic effect.

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更新日期/Last Update: 2022-08-19