[1]李艳茹,白世茹,李如意,等.PCSK9抑制剂在血脂代谢中的研究进展[J].心血管病学进展,2020,(7):729-733.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.014]
 LI Yanru,BAI Shiru,LI Ruyi,et al.PCSK9 Inhibitors in Lipid Metabolism[J].Advances in Cardiovascular Diseases,2020,(7):729-733.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.014]
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PCSK9抑制剂在血脂代谢中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年7期
页码:
729-733
栏目:
出版日期:
2020-07-25

文章信息/Info

Title:
PCSK9 Inhibitors in Lipid Metabolism
作者:
李艳茹 白世茹 李如意 杜荣品
(1.河北省人民医院心内科,河北 石家庄 050000;2.河北医科大学研究生学院,河北 石家庄 050000)
Author(s):
LI YanruBAI ShiruLI RuyiDU Rongpin
(Department of Cardiology, Hebei General Hospital,Shijiazhuang 050000, Hebei,China; 2. Graduate School of Hebei Medical University, Shijiazhuang 050000, Hebei,China)
关键词:
动脉粥样硬化性心血管疾病低密度脂蛋白胆固醇前蛋白转化酶枯草溶菌素9前蛋白转化酶枯草溶菌素9抑制剂
Keywords:
Atherosclerotic cardiovascular disease Low-density lipoprotein cholesterol Proprotein convertase subtilisin/kexin type 9Proprotein convertase subtilisin/kexin type 9 inhibitors
DOI:
10.16806/j.cnki.issn.1004-3934.2020.07.014
摘要:
心血管疾病是全世界范围内引起死亡的主要原因。高胆固醇血症被认为是动脉粥样硬化性心血管疾病的独立危险因素。目前他汀类药物是降脂的首选药,但在临床工作中常见患者对他汀类药物不耐受或应用大剂量他汀类药物仍难以将低密度脂蛋白降至达标水平。前蛋白转化酶枯草溶菌素9抑制剂作为新型降脂药物受到广泛关注。现着重综述前蛋白转化酶枯草溶菌素9及其抑制剂的最新研究进展、突出争议领域和未来的方向。
Abstract:
Cardiovascular disease remains a leading cause of death in the world. Hypercholesterolemia is considered to be an independent risk factor for atherosclerotic cardiovascular disease. At present, statins are the preferred drug for lipid-lowering. However, there are many patients with intolerance to statins or the application of high-dose statins are still unable to reduce low-density lipoprotein cholesterol to the standard level. Proprotein convertase subtilisin/kexin type 9 inhibitors have attracted extensive attention as a new lipid-lowering drug. In this article, the latest research progress, controversial areas and future directions of proprotein convertase subtilisin/kexin type 9 inhibitors are reviewed. 【

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更新日期/Last Update: 2020-10-09