[1]刘杨 陈明.冠心病的治疗新方向——PCSK9抑制剂[J].心血管病学进展,2021,(9):820-824.[doi:10.16806/j.cnki.issn.1004-3934.2021.09.000]
 New Direction of Coronary Heart Disease TreatmentPCSK9 Inhibitors.E-mailchenmingcq77@163.com[J].Advances in Cardiovascular Diseases,2021,(9):820-824.[doi:10.16806/j.cnki.issn.1004-3934.2021.09.000]
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冠心病的治疗新方向——PCSK9抑制剂()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年9期
页码:
820-824
栏目:
综述
出版日期:
2021-09-25

文章信息/Info

Title:
E-mailchenmingcq77@163.com
文章编号:
202104018
作者:
刘杨12 陈明 1
(1.重庆医科大学附属第一医院心内科,重庆 400016;2.重庆市云阳县人民医院,重庆 404500)
Author(s):
New Direction of Coronary Heart Disease TreatmentPCSK9 Inhibitors
LIU Yang1,2, CHEN Ming1 (1.Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China; 2. Yunyang County Peoples Hospital, Chongqing 404500,China)
关键词:
前蛋白转化酶枯草溶菌素9低密度脂蛋白胆固醇冠心病
Keywords:
Proprotein convertase subtilisin/kexin type 9 inhibitorLow-density lipoprotein cholesterolCoronary heart disease
DOI:
10.16806/j.cnki.issn.1004-3934.2021.09.000
摘要:
血脂异常,尤其是低密度脂蛋白胆固醇的升高,是冠心病的主要危险因素之一。他汀类降脂药物因其多种副作用,不能完全满足临床的需要。前蛋白转化酶枯草溶菌素9抑制剂,通过抑制前蛋白转化酶枯草溶菌素9与低密度脂蛋白胆固醇受体的结合,降低血液中低密度脂蛋白胆固醇水平,从而有效地降低冠心病事件的发生率,改善临床预后。
Abstract:
Dyslipidemia,especially the rise of low-density lipoprotein cholesterol,is one of the main risk factor of coronary heart disease. Traditional statins can’t meet people’s needs completely because of their various side effects. Proprotein convertase subtilisin/kexin type 9 inhibitor can effectively reduce the incidence of coronary heart disease and improve the clinical prognosis by inhibiting the binding of proprotein convertase subtilisin/kexin type 9 to low-density lipoprotein receptor

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备注/Memo

备注/Memo:


收稿日期:2021-04-06

更新日期/Last Update: 2021-10-21