[1]彭可玲 贾晓艳 王华 刘永铭.铁死亡与心力衰竭的研究进展[J].心血管病学进展,2022,(5):432-434.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.012]
 PENG Keling,JIA Xiaoyan,WANG Hua,et al.Ferroptosis and Heart Failure[J].Advances in Cardiovascular Diseases,2022,(5):432-434.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.012]
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铁死亡与心力衰竭的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年5期
页码:
432-434
栏目:
出版日期:
2022-05-25

文章信息/Info

Title:
Ferroptosis and Heart Failure
作者:
彭可玲1 贾晓艳 1 王华 1 刘永铭 2
(1.兰州大学第一临床医学院,甘肃 兰州730000;2.兰州大学第一医院老年心血管科 甘肃省老年疾病临床医学研究中心,甘肃 兰州730000)
Author(s):
PENG Keling1JIA Xiaoyan1WANG Hua1LIU Yongming2
(1.The First Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China; 2.Department of Geriatric Cardiology,The First Hospital of Lanzhou University,Gansu Provincial Clinical Research Center for Geriatric Diseases,Lanzhou 730000,Gansu,China)
关键词:
铁死亡心力衰竭细胞死亡
Keywords:
FerroptosisHeart failureCell death
DOI:
10.16806/j.cnki.issn.1004-3934.2022.05.012
摘要:
铁死亡是一种非凋亡形式的细胞死亡,涉及铁代谢、氨基酸代谢和脂质代谢三个过程。心力衰竭作为世界范围内的重大公共卫生问题,且随老龄化的发展呈持续增高趋势,铁死亡在其发生和发展过程中发挥了至关重要的作用。现从炎症、心脏毒性损害和心肌肥厚及纤维化几方面综述铁死亡对心力衰竭病理生理机制的影响,为防治提供参考。
Abstract:
Ferroptosis is a non-apoptotic form of cell death,involving iron metabolism,amino acid metabolism and lipid metabolism. As a major public health problem worldwide,heart failure continues to increase with the development of aging,and ferroptosis plays a crucial role in its occurrence and development. This paper reviews the effect of ferroptosis on the pathophysiological mechanism of heart failure from inflammation,cardiotoxic damage,myocardial hypertrophy and fibrosis,providing reference for prevention and treatment.

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更新日期/Last Update: 2022-06-30