[1]许海南 龙明智.新型降脂药物干扰小RNA Inclisiran最新研究进展[J].心血管病学进展,2021,(7):590-592,618.[doi:10.16806/j.cnki.issn.1004-3934.2021.07.004]
 XU Hainan,LONG Mingzhi.Small Interfering RNA Inclisiran[J].Advances in Cardiovascular Diseases,2021,(7):590-592,618.[doi:10.16806/j.cnki.issn.1004-3934.2021.07.004]
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新型降脂药物干扰小RNA Inclisiran最新研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年7期
页码:
590-592,618
栏目:
出版日期:
2021-07-25

文章信息/Info

Title:
Small Interfering RNA Inclisiran
作者:
许海南 龙明智
(南京医科大学第二附属医院心血管内科,江苏 南京 210011)
Author(s):
XU Hainan LONG Mingzhi
(Department of Cardiology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,Jiangsu,China)
关键词:
低密度脂蛋白胆固醇前蛋白转化酶枯草溶菌素9干扰小RNAInclisiran
Keywords:
Low-density lipoprotein cholesterolPCSK9Small interfering RNAInclisiran
DOI:
10.16806/j.cnki.issn.1004-3934.2021.07.004
摘要:
血脂异常是动脉粥样硬化性疾病的主要危险因素之一,临床上有相当比例患者即使应用大剂量他汀类药物仍不能使低密度脂蛋白胆固醇(LDL-C)达标。前蛋白转化酶枯草溶菌素9(PCSK9)是近年来发现的非他汀类降脂药物作用的新靶点,目前已上市的针对PCSK9的单克隆抗体可使LDL-C水平显著降低,但因其需每2~4周的皮下注射及价格昂贵,使得患者的依从性降低,影响药物的推广应用。小分子干扰RNA inclisiran是一种经化学修饰的双链RNA,可直接抑制肝脏中PCSK9的合成,目前已公布的inclisiran大型临床试验ORION系列研究均表明其一年两次的给药方案可使LDL-C水平显著降低,现就inclisiran的最新研究进展加以综述。
Abstract:
Dyslipidemia is one of the main risk factors of atherosclerotic diseases. In clinic, a considerable proportion of patients can not reach the standard of low-density lipoprotein cholesterol (LDL-C) even with high-dose statins . Proprotein convertase subtilisin/kexin type 9(PCSK9) is a new target of nonstatin lipid-lowering drugs discovered in recent years. Currently, the monoclonal antibody against PCSK9 on the market can significantly reduce the LDL-C level. However, due to its subcutaneous injection every 2~4 weeks and high price, the compliance of patients is reduced, which affects the promotion and application of drugs. Small interfering RNA(inclisiran) is a kind of chemically modified double stranded RNA,which can directly inhibit the synthesis of PCSK9 in liver. The Orion series of published large-scale clinical trials of inclisiran have shown that its twice-a-year administration can significantly reduce the level of LDL-C. This article reviews the latest research progress of inclisiran.

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更新日期/Last Update: 2021-09-10