[1]李开 饶莉.线粒体自噬的分子生物学过程及其在心脏疾病中的作用[J].心血管病学进展,2022,(3):222-224,228.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
 LI Kai,RAO Li.Molecular Biological Process of Mitophagy and Its Role in Heart Diseases[J].Advances in Cardiovascular Diseases,2022,(3):222-224,228.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
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线粒体自噬的分子生物学过程及其在心脏疾病中的作用()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年3期
页码:
222-224,228
栏目:
综述
出版日期:
2022-03-25

文章信息/Info

Title:
Molecular Biological Process of Mitophagy and Its Role in Heart Diseases
文章编号:
202101049
作者:
李开 饶莉
(四川大学华西医院心脏内科,四川 成都 610041)
Author(s):
LI Kai RAO Li
(Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041,Sichuan,China)
关键词:
线粒体自噬线粒体自噬心脏疾病
Keywords:
Mitophagy Autophagy Mitochondria Heart diseases
DOI:
10.16806/j.cnki.issn.1004-3934.2022.03.000
摘要:
线粒体自噬是指自噬小体选择性地将受损线粒体包裹并转运至溶酶体水解的过程,参与线粒体的质量控制及细胞稳态的维持。心脏作为机体的“泵”器官,需要充足的能量以满足心肌细胞的收缩功能,当线粒体自噬不足时可能会致使心肌细胞受损,从而介导心脏疾病的发生。因此,现针对线粒体自噬的分子生物学过程及其在心脏疾病中的作用展开综述,以期为心脏疾病的治疗手段提供新思路。
Abstract:
Mitophagy is a process that autophagosome selectively package and transport damaged mitochondria to lysosome for hydrolysis, which participate in the quality control of mitochondria and maintenance of cell homeostasis. As a “pump” organ, the heart needs sufficient energy to meet the contractile function of cardiomyocytes, and insufficient mitophagy can lead to abnormal mitochondrial accumulation and cause heart diseases. This article will review the process of mitophagy and its role in heart diseases, thus providing new ideas for the treatments of heart diseases

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更新日期/Last Update: 2022-04-20