[1]张甜甜 安军 李伟 凌宏威 李树法.2型糖尿病合并冠心病患者小而密低密度脂蛋白与其冠状动脉病变严重程度的相关性研究[J].心血管病学进展,2021,(5):470-475.[doi:10.16806/j.cnki.issn.1004-3934.2021.05.020]
 ZHANG Tiantian,AN Jun,LI Wei,et al.Correlation Between Small and Dense Low Density Lipoprotein and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease[J].Advances in Cardiovascular Diseases,2021,(5):470-475.[doi:10.16806/j.cnki.issn.1004-3934.2021.05.020]
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2型糖尿病合并冠心病患者小而密低密度脂蛋白与其冠状动脉病变严重程度的相关性研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年5期
页码:
470-475
栏目:
论著
出版日期:
2021-05-25

文章信息/Info

Title:
Correlation Between Small and Dense Low Density Lipoprotein and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease
作者:
张甜甜1 安军2 李伟1 凌宏威1 李树法34
(1.徐州医科大学研究生学院 徐州医科大学附属医院内分泌与代谢性疾病科,江苏 徐州 221000;2.解放军总医院第三医学中心内分泌科,北京 100089;3.徐州医科大学临床医学院,江苏 徐州221000;4.青岛大学附属医院内分泌与代谢性疾病科,山东 青岛 266000)
Author(s):
ZHANG Tiantian1AN Jun2LI Wei1LING Hongwei1LI Shufa34
(1.Department of Endocrinology and Metabolic Diseases, The Affiliated Hospital of Xuzhou Medical University,Graduate School of Xuzhou Medical University,Xuzhou 221000,Jiangsu,China; 2.Department of Endocrinology, Third Medical Center of PLA General Hospital, Beijing 100089 , China; 3.School of Clinical MedicineXuzhou Medical UniversityXuzhou 221000 Jiangsu,China; 4.Department of Endocrinology and Metabolic Diseases,Affiliated Hospital of Qingdao University,Qingdao 266000,Shandong,China)
关键词:
2型糖尿病冠心病小而密低密度脂蛋白Gensini评分
Keywords:
Type 2 diabetes mellitusCoronary heart diseaseSmall and dense low density lipoproteinGensini score
DOI:
10.16806/j.cnki.issn.1004-3934.2021.05.020
摘要:
目的 探讨小而密低密度脂蛋白(sdLDL)与2型糖尿病(T2DM)伴冠心病(CHD)患者冠状动脉病变严重程度的相关性研究。方法 随机选取2019年9月—2020年5月于徐州医科大学附属医院就诊的470例因可疑冠心病接受了冠状动脉造影检查的患者为研究对象,其中单纯CHD组295例,T2DM+CHD组175例。收集研究对象的临床资料,分析两组患者血脂指标、其他生化指标及Gensini评分的差异。结果 sdLDL是Gensini评分评估T2DM合并CHD患者其冠状动脉病变严重程度的重要影响因素。在T2DM+CHD组患者中,sdLDL对Gensini评分偏高的预测价值明显优于低密度脂蛋白胆固醇(AUC分别为: 0.743和 0.644,P=0.018)。结论 sdLDL是T2DM伴CHD患者冠状动脉病变严重程度的预测因素,sdLDL的升高能在一定程度上预测T2DM伴CHD患者的心血管风险。
Abstract:
Objective To explore the correlation between small and dense low density lipoprotein (sdLDL) and the severity of coronary artery disease in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease( CHD). Methods A random selection of 470 patients who were treated at the Affiliated Hospital of Xuzhou Medical University from September 2019 to May 2020 who underwent coronary angiography for suspicious CHD were selected as the research objects, of which 295 were in the CHD-only group and 175 cases in the T2DM+CHD group. Collect the clinical data of the study subjects, analyze the differences in blood lipid indexes,other biochemical 基金项目:国家自然科学资金(81570694)通信作者:李树法,E-mail:shufali@163.comindexes and Gensini scores between the two groups of patients. Results sdLDL is an important factor to evaluate the severity of coronary artery lesions in patients with T2DM complicated with CHD by Gensini score. In the T2DM+CHD group, the predictive value of sdLDL for higher Gensini score was significantly better than low density lipoprotein cholesterol (AUC=0.743,AUC=0.644,P=0.018). Conclusion sdLDL is a predictive factor for the severity of coronary artery lesions in patients with T2DM and CHD, and the increase of sdLDL can predict the cardiovascular risk of patients with T2DM and CHD to a certain extent.

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更新日期/Last Update: 2021-06-17