[1]于博文 修成奎 王雪 杨静 雷燕.内皮微粒在临床中的研究进展及应用[J].心血管病学进展,2021,(1):76-80.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
　YU Bowen,XIU Chengkui,WANG Xue,et al.Research Progress and Application of Endothelial Microparticles in Clinic[J].Advances in Cardiovascular Diseases,2021,(1):76-80.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
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内皮微粒在临床中的研究进展及应用()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年1期
页码:
76-80
栏目:
综述
出版日期:
2021-01-25

文章信息/Info

Title:
Research Progress and Application of Endothelial Microparticles in Clinic
文章编号:
202005116
作者:
于博文1; 2 修成奎1 王雪1 杨静1 雷燕1
(中国中医科学院医学实验中心 北京市中医药防治重大疾病基础研究重点实验室,北京 100700;2. 中国中医科学院博士后科研流动站,北京 100700)
Author(s):
YU Bowen1; 2; XIU Chengkui1; WANG Xue1; YANG Jing1; LEI Yan1
Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases,Medical Experiment Center,China Academy of Chinese Medical Sciences, Beijing 100700,China; 2.Center for Post-doctoral Studies,China Academy of Chinese Medical Sciences,Beijing 100700,China)
关键词:
内皮微粒; 内皮功能障碍; 生物标志物; 血管健康
Keywords:
Endothelial microparticles; Endothelial dysfunction; Biomarker;  Vascular health
DOI:
10.16806/j.cnki.issn.1004-3934.2021.01.000
摘要:
内皮微粒是从激活或损伤的内皮细胞上脱落的微小囊泡，是一种新的细胞间通讯方式，在炎症反应、凝血反应和血管生成等方面发挥重要作用，可作为内皮功能障碍和血管健康的生物标志物，并且与多种疾病密切相关。但目前对内皮微粒分子机制的理解还不够深入，在其临床研究及检测方法上存在局限性，无法人为调控内皮微粒的释放，这给以内皮微粒为疾病靶标的转化医学研究带来了挑战。现主要从内皮微粒的概念、病理生理功能、临床应用、检测方法以及在临床研究中存在的问题等方面的研究进展进行综述。
Abstract:
Endothelial microparticles(EMP) are small vesicles that released from activated or damaged endothelial cells. EMP are regard as a new way of intercellular communication and play an important role in inflammatory response,coagulation response and angiogenesis. Besides,EMP are biomarkers of endothelial dysfunction and vascular health,and are closely related to a variety of diseases. However,our understanding of the molecular mechanism of EMP is not deep enough. There are limitations in clinical research, detection methods and the regulation of EMP release have brought challenges to the research of translational medicine which takes EMP as disease targets. This paper review s the research progress in the field of EMP from the concept,pathophysiological function,clinical application,detection methods and existing problems in clinical research.

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更新日期/Last Update: 2021-03-18