[1]王佳玲 叶建荣.2型糖尿病弱化远端缺血预处理的心肌保护作用[J].心血管病学进展,2021,(1):56-58.[doi:【DOI】10.16806/j.cnki.issn.1004-3934.2021.1.000]
 WANG Jialing,YE Jianrong.Cardioprotection of Type 2 Diabetes Mellitus with Weakened Remote Ischemic Preconditioning[J].Advances in Cardiovascular Diseases,2021,(1):56-58.[doi:【DOI】10.16806/j.cnki.issn.1004-3934.2021.1.000]
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2型糖尿病弱化远端缺血预处理的心肌保护作用()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年1期
页码:
56-58
栏目:
综述
出版日期:
2021-01-25

文章信息/Info

Title:
Cardioprotection of Type 2 Diabetes Mellitus with Weakened Remote Ischemic Preconditioning
文章编号:
202004193
作者:
王佳玲 叶建荣
(新疆医科大学第一附属医院,新疆 乌鲁木齐 830011)
Author(s):
WANG JialingYE Jianrong
(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011, Xinjiang,China)
关键词:
2型糖尿病远端缺血预处理心肌梗死
Keywords:
Type 2 diabetesRemote ischemic preconditioning Myocardial infarction
DOI:
【DOI】10.16806/j.cnki.issn.1004-3934.2021.1.000
摘要:
2型糖尿病患者对一氧化氮舒张血管作用敏感性下降,微血管病变导致心肌的氧储备较差,新生血管不能有效形成等因素导致2型糖尿病患者发生心肌梗死后预后不佳。远端缺血预处理被证实具有保护心肌和缩小梗死面积的作用,然而2型糖尿病似乎弱化了远端缺血预处理的心肌保护作用,其原因可能是2型糖尿病患者体内磷脂酰肌醇3-激酶/蛋白激酶B信号通路长期受抑制、血管舒张功能的减弱、氧化应激和炎症水平的长期升高、长期的自噬功能受抑制和自主神经病变。
Abstract:
The sensitivity of patients with type 2 diabetes to vasorelaxation effect of NO is decreased,microvascular disease leads to poor oxygen reserve of myocardium,and neovascularization cannot be effectively formed. All of these factors will lead to poor prognosis in patients with type 2 diabetes after myocardial infarction. Remote ischemic preconditioning has been proved to protect myocardium and reduce infarct size. However,type 2 diabetes seems to weaken the cardioprotection effect of remote ischemic preconditioning,which may be due to the long-term inhibition of PI3K/AKT signaling pathway,the weakening of vascular diastolic function, long-term increase in oxidative stress and inflammation,long-term inhibition of autophagy and autonomic neuropathy in patients with type 2 diabetes

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更新日期/Last Update: 2021-03-18