[1]刘雪鸢 徐燕萍 殷跃辉.交感神经去除术在肺动脉高压治疗中的研究进展[J].心血管病学进展,2020,(5):480-484.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.010]
 LIU Xueyuan,XU Yanping,YIN Yuehui.Sympathetic Denervation in Treatment of Pulmonary Hypertension[J].Advances in Cardiovascular Diseases,2020,(5):480-484.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.010]
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交感神经去除术在肺动脉高压治疗中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年5期
页码:
480-484
栏目:
出版日期:
2020-05-25

文章信息/Info

Title:
Sympathetic Denervation in Treatment of Pulmonary Hypertension
作者:
刘雪鸢 徐燕萍 殷跃辉
(1.重庆医科大学研究生院,重庆400010;2.重庆医科大学附属第二医院心血管内科,重庆400010)
Author(s):
LIU Xueyuan XU Yanping YIN Yuehui
(1.Chongqing Medical University Graduate School,Chongqing 400010,China; 2. Department of Cardiology,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
关键词:
肺动脉高压交感神经活性交感神经去除术
Keywords:
Pulmonary hypertensionSympathetic activitySympathetic denervation
DOI:
10.16806/j.cnki.issn.1004-3934.2020.05.010
摘要:
肺动脉高压是一种复杂的临床综合征,虽然在心肺血管疾病中发病率不高,但因其严重影响患者生活质量,致死风险高,被称之为心血管疾病中的恶性疾病。靶向药物治疗使得肺动脉高压病情得到一定程度控制,但整体控制率仍不容乐观。随着肺动脉高压相关研究的推进,目前认为交感神经的过度激活在肺动脉高压的发生和维持中起到一定作用,且基于调节自主神经活性的药物和器械治疗在肺动脉高压中的研究得到了一些发现。现就交感神经在肺动脉高压发生和发展的作用、肺动脉神经分布特点和交感神经活性调节的非药物治疗研究进行综述,以探讨肺动脉高压治疗的新思路。
Abstract:
Pulmonary hypertension is a complex clinical syndrome.Though it has the low morbidity,it is regarded as the malignant disease among the cardiovascular diseases due to its high risk of mortality and serious influence on the life quality of patients. Targeted medicine treatment makes the disease controlled somehow,but it’s not satisfying. As the relative studies advanced,researchers pointed out that the overactivation of sympathetic nerve plays a role in the occurrence and maintenance of pulmonary hypertension. Moreover ,exciting findings were noted in the research of the pulmonary hypertension treatment by drug and device modulating the autonomic nerve activities. This paper reviews the function of sympathetic nerve in the pulmonary hypertension development ,the characters of pulmonary artery nerve distribution and the non-drug treatment research of sympathetic nerve activity modulation, for explor ing the new treatment perspective of pulmonary hypertension.

参考文献/References:


[1] Simonneau G,Montani D,Celermajer DS,et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension[J]. Eur Respir J,2019,53(1).pii:1801913.

[2] Jing ZC,Xu XQ,Han ZY,et al. Registry and survival study in Chinese patients with idiopathic and familial pulmonary arterial hypertension[J]. Chest,2007,132(2):373-379.

[3] Lau EMT,Giannoulatou E,Celermajer DS,et al. Epidemiology and treatment of pulmonary arterial hypertension[J]. Nat Rev Cardiol,2017,14(10):603-614.

[4] Kovacs G,Dumitrescu D,Barner A,et al. Definition,clinical classification and initial diagnosis of pulmonary hypertension:updated recommendations from the Cologne Consensus Conference 2018[J]. Int J Cardiol,2018,272S:11-19.

[5] Haberberger R,Schemann M,Sann H,et al. Innervation pattern of guinea pig pulmonary vasculature depends on vascular diameter[J]. J Appl Physiol (1985),1997,82(2):426-434.

[6] Zhang Y,Chen W,Xu Y,et al. Nerve distribution of canine pulmonary arteries and potential clinical implications[J].Am J Transl Res,2016,8(2):365-374.

[7] Zhou L,Zhang J,Jiang XM,et al. Pulmonary artery denervation attenuates pulmonary arterial remodeling in dogs with pulmonary arterial hypertension induced by dehydrogenized monocrotaline[J]. JACC Cardiovasc Interv,2015,8(15):2013-2023.

[8] Zhang H,Zhang J,Chen MX,et al. Pulmonary artery denervation significantly increases 6-min walk distance for patients with combined pre- and post-capillary pulmonary hypertension associated with left heart failure:the PADN-5 study[J]. JACC Cardiovasc Interv,2019, 12(3):274-284.

[9] Bogaard HJ,Natarajan R,Mizuno S,et al. Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats[J]. Am J Respir Crit Care Med,2010,182(5):652-660.

[10] Chen SL,Zhang FF,Xu J,et al. Pulmonary artery denervation to treat pulmonary arterial hypertension:the single-center,prospective,first-in-man PADN-1 study(first-in-man pulmonary artery denervation for treatment of pulmonary artery hypertension)[J]. J Am Coll Cardiol,2013,62(12):1092-1100.

[11] Linz D,Hohl M,Schutze J,et al. Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats:the role of renal sympathetic innervation[J]. Am J Hypertens,2015,28(2):256-265.

[12] Liu Q,Song JY,Lu D,et al. Effects of renal denervation on monocrotaline induced pulmonary remodeling[J]. Oncotarget,2017,8(29):46846-46855.

[13] Vaillancourt M,Chia P,Sarji S,et al. Autonomic nervous system involvement in pulmonary arterial hypertension[J]. Respir Res,2017,18(1):201.

[14] Verity MA,Bevan JA. Fine structural study of the terminal effecror plexus, neuromuscular and intermuscular relationships in the pulmonary artery[J]. J Anat,1968,103(Pt 1):49-63.

[15] Bristow MR,Ginsburg R,Umans V,et al. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure[J]. Circ Res,1986,59(3):297-309.

[16] Velez-Roa S,Ciarka A,Najem B,et al. Increased sympathetic nerve activity in pulmonary artery hypertension[J]. Circulation,2004,110(10):1308-1312.

[17] Chen SL,Zhang YJ,Zhou L,et al. Percutaneous pulmonary artery denervation completely abolishes experimental pulmonary arterial hypertension in vivo[J]. EuroIntervention,2013,9(2):269-276.

[18] Fujisawa T,Kataoka M,Kawakami T,et al. Pulmonary artery denervation by determining targeted ablation sites for treatment of pulmonary arterial hypertension[J]. Circ Cardiovasc Interv,2017,10(10).pii:e005812.

[19] Liu C,Jiang XM,Zhang J,et al. Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system[J]. BMC Cardiovasc Disord,2016,16(1):192.

[20] Rothman AMK,Arnold ND,Chang W,et al. Pulmonary artery denervation reduces pulmonary artery pressure and induces histological changes in an acute porcine model of pulmonary hypertension[J]. Circ Cardiovasc Interv,2015,8(11):e002569.

[21] Zhang H,Zhang J,Xie DJ,et al. Pulmonary artery denervation for treatment of a patient with pulmonary hypertension secondary to left heart disease[J]. Pulm Circ,2016,6(2):240-243.

[22] Esler MD,Bohm M,Sievert H,et al. Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension:36 month results from the SYMPLICITY HTN-2 randomized clinical trial[J]. Eur Heart J,2014,35(26):1752-1759.

[23] Hoogerwaard AF,Adiyaman A,de Jong MR,et al. Changes in arterial pressure hemodynamics in response to renal nerve stimulation both before and after renal denervation[J]. Clin Res Cardiol,2018,107 (12),1131-1138.

[24] Krum H,Schlaich MP,Sobotka PA,et al. Percutaneous renal denervation in patients with treatment-resistant hypertension:final 3-year report of the Symplicity HTN-1 study[J]. Lancet,2014,383(9917):622-629.

[25] Li ZZ,Jiang H,Chen D,et al. Renal sympathetic denervation improves cardiac dysfunction in rats with chronic pressure overload[J]. Physiol Res,2015,64(5):653-662.

[26] Liang Z,Shi XM,Liu LF,et al. Renal denervation suppresses atrial fibrillation in a model of renal impairment[J]. PLoS One,2015,10(4):e0124123.

[27] Symplicity HTN-2 Investigators,Esler MD,Krum H,et al. Renal sympathetic denervation in patients with treatment-resistant hypertension(The Symplicity HTN-2 Trial):a randomised controlled trial[J]. Lancet,2010,376(9756):1903-1909.

[28] Zhao QY,Jiang XJ,Tang YH,et al. Beneficial effects of renal denervation on pulmonary vascular remodeling in experimental pulmonary artery hypertension[J]. Rev Esp Cardiol (Engl Ed),2015,68(7):562-570.

[29] Mahfoud F,Tunev S,Ewen S,et al. Impact of lesion placement on efficacy and safety of catheter-based radiofrequency renal denervation[J]. J Am Coll Cardiol,2015,66(16):1766-1775.

[30] da Silva Gon?alves Bos D, Happé C, Schalij I,et al. Renal denervation reduces pulmonary vascular remodeling and right ventricular diastolic stiffness in experimental pulmonary hypertension[J]. JACC Basic Transl Sci,2017,2(1):22-35.

[31] Huang Y,Liu YW,Pan HZ,et al. Transthoracic pulmonary artery denervation for pulmonary arterial hypertension[J]. Arterioscler Thromb Vasc Biol,2019,39(4):704-718.

[32] Fudim M,Sobotka AA,Yin YH,et al. Selective vs. global renal denervation: a case for less is more[J]. Curr Hypertens Rep,2018,20(5):37.

[33] Lu J,Wang Z,Zhou T,et al. Selective proximal renal denervation guided by autonomic responses evoked via high-frequency stimulation in a preclinical canine model[J]. Circ Cardiovasc Interv,2015,8(6).pii:e001847.

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更新日期/Last Update: 2020-08-12