[1]汪汉,刘英杰,王燕凤.长链非编码RNA与肺动脉高压[J].心血管病学进展,2019,(6):898-901.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.015]
 WANG Han,LIU Yingjie,WANG Yanfeng.Long Non-coding RNA in Pulmonary Arterial Hypertension[J].Advances in Cardiovascular Diseases,2019,(6):898-901.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.015]
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长链非编码RNA与肺动脉高压()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年6期
页码:
898-901
栏目:
综述
出版日期:
2019-09-25

文章信息/Info

Title:
Long Non-coding RNA in Pulmonary Arterial Hypertension
作者:
汪汉 刘英杰 王燕凤
(成都市第三人民医院心内科 成都市心血管病研究所四川 成都 610031)
Author(s):
WANG Han LIU Yingjie WANG Yanfeng

(The Department of Cardiology, The Third People ’ s Hospital of Chengdu,?Cardiovascular Disease Research Institute, Chengdu 610031, Sichuan, China)

关键词:
长链非编码RNA 肺动脉高压 竞争性内源RNA
Keywords:
Long non-coding RNA Pulmonary arterial hypertension Connective tissue disease
DOI:
10.16806/j.cnki.issn.1004-3934.2019.06.015
摘要:

肺动脉高压是一类 无特效治疗药物的灾难性疾病 。 长链非编码RNA与miRNA结合形成竞争性内源RNA对肺动脉高压进行调节是目前常见的模式,但截至目前,尚无长链非编码RNA诊断、治疗肺动脉高压的可信赖的研究,下一步研究应当继续聚焦于 长链非编码 RNA对肺动脉高压发生发展的影响。

Abstract:
Pulmonary arterial hypertension is a devastating disease without effective drugs available for its treatment. Long non-coding RNA (lncRNA) often combines with miRNA to form competitive endogenous RNA to regulate pulmonary hypertension, but so far, there is no reliable evidence on diagnosis and treatment of lncRNA for pulmonary hypertension, and the next research should continue to focus on the impact of lncRNA on the occurrence and development of pulmonary hypertension.

参考文献/References:

[1]. 付准, 杨毅宁. 长链非编码RNA与心血管疾病发展关系的研究进展[J]. 心血管病学进展,2018,39(2):275-278.
[2] Zhang CY, Liu M, Wan JM, et al. Role of noncoding RNA in pulmonary arterial hypertension and potential drug therapeutic target[J]. Curr Top Med Chem,2018,18(12):975-986.
[3] Martens L,Rühle F,Stoll M. LncRNA secondary structure in the cardiovascular system[J]. Noncoding RNA Res,2017,2(3-4):137-142.
[4] Sun Z,Liu Y,Yu F.Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline[J]. Biomed Pharmacother,2019,115:108933
[5] Su H,Xu X,Yan C,et al. LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension[J]. Respir Res,2018,19(1):254
[6] Jandl K,Thekkekara Puthenparampil H,Marsh LM,et al. Long non-coding RNAs influence the transcriptome in pulmonary arterial hypertension:the role of PAXIP1-AS1[J]. J Pathol,2019,247(3):357-370.
[7] Zhu TT,Sun RL,Yin YL,et al. Long noncoding RNA UCA1 promotes the proliferation of hypoxic human pulmonary artery smooth muscle cells[J]. Pflugers Arch,2019,471(2):347-355.
[8] Zhang H,Liu Y,Yan L,et al. Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation[J]. Cardiovasc Res,2019,115(3):647-657.
[9] Chen J,Guo J,Cui X,et al. The long noncoding RNA LnRPT is regulated by PDGF-BB and modulates the proliferation of pulmonary artery smooth muscle cells[J]. Am J Respir Cell Mol Biol,2018,58(2):181-193.
[10] Bischoff FC,Werner A,John D,et al. Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes[J]. Circ Res,2017,121(4):368-375.
[11] Sharma S,Findlay GM,Bandukwala HS,et al. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex[J]. Proc Natl Acad Sci USA,2011,108(28):11381-11386.
[12] Leung A,Trac C,Jin W,et al. Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells[J]. Circ Res,2013,13(3): 266-278.
[13] Josipovic I,Fork C,Preussner J,et al. PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells[J]. Acta Physiol (Oxf),2016,218(1):13-27.
[14] Gong J,Chen Z,Chen Y,et al. Long non-coding RNA CASC2 suppresses pulmonary artery smooth muscle cell proliferation and phenotypic switch in hypoxia-induced pulmonary hypertension[J]. Respir Res,2019,20(1):53.
[15] Zhu B,Gong Y,Yan G,et al. Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21[J]. Biochem Biophys Res Commun,2018,495(3):2125-2132.
[16] Sun Z,Nie X,Sun S,et al. Long non-coding RNA MEG3 downregulation triggers human pulmonary artery smooth muscle cell proliferation and migration via the p53 signaling pathway[J]. Cell Physiol Biochem,2017,42(6):2569-2581.
[17] Liu Y,Sun Z,Zhu J,et al. LncRNA-TCONS_00034812 in cell proliferation and apoptosis of pulmonary artery smooth muscle cells and its mechanism[J]. J Cell Physiol,2018,233(6):4801-4814.
[18] Han B,Bu P,Meng X,et al. Microarray profiling of long non-coding RNAs associated with idiopathic pulmonary arterial hypertension[J]. Exp Ther Med,2017,13(6):2657-2666.
[19] Gu S,Li G,Zhang X,et al. Aberrant expression of long noncoding RNAs in chronic thromboembolic pulmonary hypertension[J]. Mol Med Rep,2015,11(4):2631-2643.
[20] Cao Y,Yang Y,Wang L,et al. Analyses of long non-coding RNA and mRNA profiles in right ventricle myocardium of acute right heart failure in pulmonary arterial hypertension rats[J]. Biomed Pharmacother,2018,106:1108-1115.
[21] Wang X,Yan C,Xu X,et al. Long noncoding RNA expression profiles of hypoxic pulmonary hypertension rat model[J]. Gene,2016,579(1):23-28.
[22] Schlosser K,Hanson J,Villeneuve PJ,et al. Assessment of circulating lncRNAs under physiologic and pathologic conditions in humans reveals potential limitations as biomarkers[J]. Sci Rep,2016,6:36596.
[23]金光军,周冰之,张建成. miR-21降解PTEN影响香烟提取物诱导的PASMCs的增殖与迁移[J]. 医学研究杂志,2019,48(1):47-51,73.
[24] Leisegang MS,Fork C,Josipovic I,et al. Long noncoding RNA MANTIS facilitates endothelial angiogenic function[J]. Circulation,2017,136(1):65-79.

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备注/Memo

备注/Memo:
基金项目:四川省科技厅面上项目(2019YJ0634)收稿日期:2019-06-14
通讯作者:汪汉,E-mail:7972348@qq.com
更新日期/Last Update: 2019-12-13