[1]杨宏杰 孔彬 黄鹤.NLRP3炎症小体在心房颤动中的作用的研究进展[J].心血管病学进展,2020,(6):611.[doi:10.16806/j.cnki.issn.1004-3934.2020.06.013]
 YANG Hongjie,KONG Bin,HUANG He.Role of NLRP3 Inflammasome in Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2020,(6):611.[doi:10.16806/j.cnki.issn.1004-3934.2020.06.013]
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NLRP3炎症小体在心房颤动中的作用的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年6期
页码:
611
栏目:
综述
出版日期:
2020-06-25

文章信息/Info

Title:
Role of NLRP3 Inflammasome in Atrial Fibrillation
作者:
杨宏杰12 孔彬12 黄鹤12
(1.武汉大学人民医院心内科,湖北 武汉 430060;2.心血管病湖北省重点实验室,湖北 武汉 430060)
Author(s):
YANG Hongjie 12KONG Bin 12HUANG He12
(1.Department of Cardiology,Renmin Hospital of Wuhan University,Wuchang 430060,Wuhan,China; 2.Hubei Key Laboratory of Cardiology,Wuchang 430060,Wuhan ,China)
关键词:
心房颤动NLRP3炎症小体心脏重构
Keywords:
Atrial fibrillation NLRP3 inflammasome Cardiac remodeling
DOI:
10.16806/j.cnki.issn.1004-3934.2020.06.013
摘要:
心房颤动(房颤)的发病率与日俱增,尽管在过去二十年中,房颤的治疗手段日新月异,但房颤患者的致残率、致死率仍居高不下。因此,需继续探索治疗房颤的新型治疗靶点,从而造福临床上的房颤患者。炎症反应在房颤的发生发展过程中发挥着重要的作用。近年来,核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体在心血管疾病中的作用引起越来越多学者的关注。多项研究证实NLRP3炎症小体与房颤关系密切,但其机制尚不清楚,深入阐明NLRP3炎症小体与房颤的关系,对房颤的防治具有重要意义。现就NLRP3炎症小体与房颤的关系及其机制的研究进展做一综述。
Abstract:
The incidence of atrial fibrillation(AF) is increasing recently. Although the treatment of AF has changed rapidly over the past two decades,the morbidity and mortality rates of patients with AF remain high.Therefore,it is necessary to continue to explore new therapeutic targets for the treatment of AF,thereby benefiting patients with clinical atrial fibrillation.The inflammatory response plays an important role in the development of AF. In recent years,the role of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3) inflammasome in cardiovascular diseases has attracted?the attention of more and more scholars. A number of studies have confirmed that NLRP3 inflammasome are closely related to AF,but the mechanism is still unclear. The relationship between NLRP3 inflammasome and AF is deeply clarified,which is of great significance for the prevention and treatment of AF. This article reviews the research progress on the relationship between NLRP3 inflammasome and AF and its mechanism

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备注/Memo

备注/Memo:
基金项目:国家重点研发计划(2017YFC1700504)
更新日期/Last Update: 2020-09-22