[1]韩柯,孟祥光,赵育洁.趋化因子及其受体在肺动脉高压中的研究进展[J].心血管病学进展,2020,(3):296-300.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.020]
 HAN Ke,MENG Xiangguang,ZHAO Yujie.Chemokines and Their Receptors in Pulmonary Arterial Hypertension[J].Advances in Cardiovascular Diseases,2020,(3):296-300.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.020]
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趋化因子及其受体在肺动脉高压中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年3期
页码:
296-300
栏目:
综述
出版日期:
2020-03-25

文章信息/Info

Title:
Chemokines and Their Receptors in Pulmonary Arterial Hypertension
作者:
韩柯1 孟祥光2 赵育洁1
(1.新乡医学院,河南 新乡 4530032.郑州市第七人民医院心血管疾病及药物研究室,河南 郑州 450016)
Author(s):
HAN Ke1MENG Xiangguang2 ZHAO Yujie1
(1. Xinxiang Medical University,Xinxiang 453003,Henan,China 2. Laboratory of Cardiovascular Disease and Drug Research,The Seventh Peoples Hospital of Zhengzhou,Zhengzhou 450016,Henan,China)
关键词:
肺动脉高压趋化因子趋化因子受体
Keywords:
Pulmonary arterial hypertension Chemokines Chemokine receptors
DOI:
10.16806/j.cnki.issn.1004-3934.2020.03.020
摘要:
肺动脉高压是一种受多种因素影响的疾病,具有进行性肺动脉重塑和右心室压力负荷持续性增加的特征,最终导致右心衰竭甚至过早死亡。以往的研究表明,肺动脉高压的发生和多种趋化因子及其受体表达的失调有关,最近的报道同样认为几种趋化因子及其受体对肺动脉高压的发展产生影响,进而证明这些因子及受体可作为肺动脉高压的治疗靶点。现就趋化因子及其受体在肺动脉高压中的研究和应用进展做一综述。
Abstract:
Pulmonary arterial hypertension, featured by progressive pulmonary artery remodeling and increased pressure load of right ventricular pressure, is a kind of diseases affected by many factors, which would eventually lead to right heart failure , even early death.Previous studies have shown that the development of pulmonary arterial hypertension was associated with the dysregulated expression of several chemokines and their receptors , and the recent reports also accepted the fact that several chemokines and their receptors exerted a strong influence on p ulmonary arterial hypertension development, which further suggested that these molecule signatures be viewed as promising therapeutic targets for pulmonary arterial hypertension.This article reviews the study and application progress of chemokines and chemokine receptors in pulmonary arterial hypertension.

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备注/Memo

备注/Memo:
收稿日期:2019-09-18 通讯作者:赵育洁,E-mail:zhyj117047@sina.com
更新日期/Last Update: 2020-05-20