[1]向杰 刘明鑫 黄从新.STAT3信号通路在心房颤动中的机制研究[J].心血管病学进展,2020,(1):22-26.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.007]
 XIANG JieLIU MingxinHUANG Congxin.Mechanism of STAT3 Signaling Pathway in Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2020,(1):22-26.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.007]
点击复制

STAT3信号通路在心房颤动中的机制研究()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年1期
页码:
22-26
栏目:
综述
出版日期:
2020-02-04

文章信息/Info

Title:
Mechanism of STAT3 Signaling Pathway in Atrial Fibrillation
作者:
向杰 刘明鑫 黄从新
(武汉大学人民医院心血管内科,湖北 武汉 430060)
Author(s):
XIANG JieLIU MingxinHUANG Congxin
(Department of CardiologyRenmin Hospital of Wuhan UniversityWuhan 430060HubeiChina)
关键词:
心房颤动STAT3信号通路
Keywords:
Atrial fibrillation STAT3Signaling pathway
DOI:
10.16806/j.cnki.issn.1004-3934.2020.01.007
摘要:
STAT3是STATs家族中重要成员之一,参与调控机体内各种生物学过程,近期有研究表明心房颤动发生后STAT3信号通路被大量激活,STAT3可通过血管紧张素Ⅱ、miRNA、炎性因子、生长因子等在介导心房颤动发生的心肌纤维化、炎症、细胞凋亡等方面发挥重要的作用,因此STAT3可能是心房颤动进展过程中的关键调节因素。现就STAT3信号通路与心房颤动这一疾病间的关联及在此基础上的调控机制做一综述,以期更深入地理解心房颤动的发生机制,为心房颤动的治疗提供更加全面的理论基础。
Abstract:
STAT3 is one of the important members of the STATs family and is involved in regulating various biological processes in the body. Recent studies have shown that STAT3 signaling pathway is activated in large amounts after atrial fibrillation(AF).STAT3 plays an important role in myocardial fibrosis ,inflammation,apoptosis,etc.,which mediate atrial fibrillation through angiotensinⅡ,miRNA,inflammatory factors,growth factors,etc.Therefore,STAT3 may be a key regulator of atrial fibrillation progression. This article mainly reviews the relationship between STAT3 signaling pathway and atrial fibrillation and the regulation of this mechanism,in order to understand deeply the mechanism of atrial fibrillation and provide a more comprehensive theoretical basis for the treatment of atrial fibrillation

参考文献/References:

[1]Hilfiker-Kleiner D,Hilfiker A,Fuchs M,et al. Signal transducer and activator of transcription 3 is required for myocardial capillary growth,control of interstitial matrix deposition ,and heart protection from ischemic injury[J]. Circ Res 95(2):187-195.

[2]Kurdi M,Booz GW. JAK redux :a second look at the regulation and role of JAKs in the heart[J]. Am J Physiol Heart Circ Physiol,2009,297(5):H1545-H1556.

[3] Benussi S,de Maat GE. Atrial remodelling and function:implications for atrial fibrillation surgery[J]. Eur J Cardiothorac Surg,2018,53(suppl_1):i2-i8.

[4] Lau DH,Schotten U,Mahajan R,et al. Novel mechanisms in the pathogenesis of atrial fibrillation:practical applications[J]. Eur Heart J,2016,37(20):1573-1581.

[5]Bharadwaj U ,Kasembeli MM,Eckols TK,et al. Monoclonal antibodies specific for STAT3beta reveal its contribution to constitutive STAT3 phosphorylation in breast cancer[J]. Cancers (Basel),2014,6(4):2012-2034.

[6] Haghikia A,Ricke-Hoch M,Stapel B,et al. STAT3,a key regulator of cell-to-cell communication in the heart[J]. Cardiovasc Res,2014,102(2):281-289.

[7] Nattel S,Burstein B,Dobrev D. Atrial remodeling and atrial fibrillation:mechanisms and implications[J]. Circ Arrhythm Electrophysiol,2008,1(1):62-73.

[8] Andrade J,Khairy P,Dobrev D,et al. The clinical profile and pathophysiology of atrial fibrillation:relationships among clinical features,epidemiology,and mechanisms[J]. Circ Res,2014,114(9):1453-1468.

[9] Tan AY,Zimetbaum P. Atrial fibrillation and atrial fibrosis[J]. J Cardiovasc Pharmacol,2011,57(6):625-629.

[10] Venteclef N,Guglielmi V,Balse E,et al. Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines[J]. Eur Heart J,2015,36(13):795-805.

[11] Haghikia A,Stapel B,Hoch M,et al. STAT3 and cardiac remodeling[J]. Heart Fail Rev,2011,16(1):35-47.

[12] Li D,Shinagawa K,Pang L,et al. Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure[J]. Circulation,2001,104(21):2608-2614.

[13] Savelieva I,John CA. Atrial fibrillation and heart failure:natural history and pharmacological treatment[J]. Europace,2004,5 Suppl 1:S5-S19.

[14] Faruqi TR,Gomez D,Bustelo XR,et al. Rac1 mediates STAT3 activation by autocrine IL-6[J]. Proc Natl Acad Sci U S A,2001,98(16):9014-9019.

[15] Misao J,Hayakawa Y,Ohno M,et al. Expression of bcl-2 protein,an inhibitor of apoptosis,and Bax,an accelerator of apoptosis,in ventricular myocytes of human hearts with myocardial infarction[J]. Circulation,1996,94(7):1506-1512.

[16] Tsai CT,Lai LP,Kuo KT,et al. AngiotensinⅡactivates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts:implication for the therapeutic effect of statin in atrial structural remodeling[J]. Circulation,2008,117(3):344-355.

[17] Tsai CT,Lin JL,Lai LP,et al. Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial fibrillation[J]. Heart Rhythm,2008,5(9):1285-1293.

[18] Xue XD,Huang JH,Wang HS. AngiotensinⅡactivates signal transducers and activators of transcription 3 via Rac1 in the atrial tissue in permanent atrial fibrillation patients with rheumatic heart disease[J]. Cell Biochem Biophys,2015,71(1):205-213.

[19] Zheng LY,Zhang MH,Xue J H,et al. Effect of angiotensinⅡon STAT3 mediated atrial structural remodeling[J]. Eur Rev Med Pharmacol Sci,2014,18(16):2365-2377.

[20] Zheng L,Jia X,Zhang C,et al. AngiotensinⅡin atrial structural remodeling:the role of AngⅡ/JAK/STAT3 signaling pathway[J]. Am J Transl Res,2015,7(6):1021-1031.

[21] Huang Z,Chen XJ,Qian C,et al. Signal transducer and activator of transcription 3/microRNA-21 feedback loop contributes to atrial fibrillation by promoting atrial fibrosis in a rat sterile pericarditis model[J]. Circ Arrhythm Electrophysiol,2016,9(7), pii: e003396.

[22] Cao W,Shi P,Ge JJ. miR-21 enhances cardiac fibrotic remodeling and fibroblast proliferation via CADM1/STAT3 pathway[J]. BMC Cardiovasc Disord,2017,17(1):88.

[23] Hu YF,Chen YJ,Lin YJ,et al. Inflammation and the pathogenesis of atrial fibrillation[J]. Nat Rev Cardiol,2015,12(4):230-243.

[24] Mir SA,Chatterjee A,Mitra A,et al. Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6(IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart[J]. J Biol Chem,2012,287(4):2666-2677.

[25]Hao L,Ren M,Rong B,et al. TWEAK/Fn14 mediates atrial-derived HL-1 myocytes hypertrophy via JAK2/STAT3 signalling pathway[J]. J Cell Mol Med,2018,22(9):4344-4353.

[26]Jiang Q,Ni B,Shi J,et al. Down-regulation of ATBF1 activates STAT3 signaling via PIAS3 in pacing-induced HL-1 atrial myocytes[J]. Biochem Biophys Res Commun,2014,449(3):278-283.

[27] Krishnamurthy P,Rajasingh J,Lambers E,et al. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR[J]. Circ Res,2009,104(2):e9-e18.

[28] Obana M,Maeda M,Takeda K,et al. Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction[J]. Circulation,2010,121(5):684-691.

[29] Dong Q,Li S,Wang W,et al. FGF23 regulates atrial fibrosis in atrial fibrillation by mediating the STAT3 and SMAD3 pathways[J]. J Cell Physiol,2019,234(11):19502-19510.

[30] Chen Y,Surinkaew S,Naud P,et al. JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate[J]. Cardiovasc Res,2017,113(3):310-320.

[31] Chang SH,Yeh YH,Lee JL,et al. Transforming growth factor-beta-mediated CD44/STAT3 signaling contributes to the development of atrial fibrosis and fibrillation[J]. Basic Res Cardiol,2017,112(5):58.

相似文献/References:

[1]贺鹏康,周菁.心房颤动治疗新技术——冷冻球囊消融[J].心血管病学进展,2016,(1):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
 HE Pengkang,ZHOU Jing.Cryoballoon Ablation, A Novel Technology for Atrial Fibrillation Treatment[J].Advances in Cardiovascular Diseases,2016,(1):1.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.001]
[2]都明辉,施海峰*,佟佳宾,等.心房颤动消融相关性无症状性脑缺血[J].心血管病学进展,2016,(1):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
 DU Minghui,SHI Haifeng*,TONG Jiabin,et al.Silent Cerebral Ischemia Related to Atrial Fibrillation Ablation[J].Advances in Cardiovascular Diseases,2016,(1):3.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.002]
[3]郑环杰,综述,肖骅,等.心房颤动抗栓治疗研究进展[J].心血管病学进展,2016,(2):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
 ZHENG Huanjie,XIAO Hua.Progress of Antithrombotic Therapy in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(1):142.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.012]
[4]张清,综述,罗素新,等.新型Xa 因子抑制剂———依度沙班在心房颤动患者抗凝治疗中的研究进展[J].心血管病学进展,2016,(2):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
 ZHANG Qing,LUO Suxin,TANG Jiong.Novel Factor Xa Inhibitors—Edoxaban in Prevention of Stroke in Patients with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(1):151.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.014]
[5]胡红玲,综述,罗素新,等.预防非瓣膜性心房颤动性脑卒中的治疗新进展[J].心血管病学进展,2016,(3):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
 HU Hongling,LUO Suxin.New Progress in the Treatment for Cerebral Apoplexy of Nonvalvular Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(1):250.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.009]
[6]王超,杨国澍,综述,等.关附甲素治疗心房颤动的研究进展[J].心血管病学进展,2016,(3):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
 WANG Chao,YANG Guoshu,CAI Lin,et al.Research Progress of the Treatment of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(1):254.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.010]
[7]徐小东,综述,杨东辉,等.决奈达隆治疗心房颤动的现状及展望[J].心血管病学进展,2016,(4):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
 XU Xiaodong,YANG Donghui.Status and Prospect of Dronedarone in Treating Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2016,(1):368.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.011]
[8]张莎,储国俊,吴弘.经导管左心耳封堵术的临床应用进展[J].心血管病学进展,2015,(5):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
 ZHANG Sha,CHU Guojun,WU Hong.Clinial Application Advances in Left Atrial Appendage Closure[J].Advances in Cardiovascular Diseases,2015,(1):547.[doi:10.3969/j.issn.1004-3934.2015.05.006]
[9]汪俊,杨浩.心房颤动射频消融的术式演变[J].心血管病学进展,2015,(5):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
 WANG Jun,YANG Hao.Evolution of Radiofrequency Ablation of Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2015,(1):574.[doi:10.3969/j.issn.1004-3934.2015.05.013]
[10]赵璐,苏立.心房颤动与离子通道重构研究进展[J].心血管病学进展,2015,(5):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]
 ZHAO Lu,SU Li.Research Progress of Atrial Fibrillation and Ion Channel Remodeling[J].Advances in Cardiovascular Diseases,2015,(1):580.[doi:10.3969/j.issn.1004-3934.2015.05.014]

备注/Memo

备注/Memo:
通讯作者:黄从新,E-mail:Huangcongxin@VIP.163.com
更新日期/Last Update: 2020-03-23