[1]马天雪 赵玉娟.长链非编码RNA及相关调控通路与急性心肌梗死的研究进展[J].心血管病学进展,2019,(8):1099-1103.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.007]
　MA Tianxue,ZHAO Yujuan.Long Non-coding RNA and Its Related Regulatory Pathways and Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(8):1099-1103.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.007]
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长链非编码RNA及相关调控通路与急性心肌梗死的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年8期
页码:
1099-1103
栏目:
综述
出版日期:
2019-11-25

文章信息/Info

Title:
Long Non-coding RNA and Its Related Regulatory Pathways and Acute Myocardial Infarction
作者:
马天雪1 赵玉娟2
( 1．哈尔滨医科大学附属第一医院研究生培养基地,哈尔滨 黑龙江 150001;2．哈尔滨医科大学附属第一医院心内科,哈尔滨 黑龙江 150001)
Author(s):
MA Tianxue1; ZHAO Yujuan2
(1.Postgraduate Training Base of The First Affiliated Hospital,Harbin Medical University, Harbin 150001,Heilongjiang,China; 2.Department of Cardiology, The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)
关键词:
急性心肌梗死; 长链非编码RNA; 调控通路; 诊断治疗靶点
Keywords:
Acute myocardial infarction;  Long non-coding RNA;  Regulatory pathways;  Diagnostic therapeutic targets
DOI:
10.16806/j.cnki.issn.1004-3934.2019.08.007
摘要:
急性心肌梗死是指冠状动脉血供急剧减少或中断，使相应心肌严重而持久的缺血坏死。长链非编码RNA（lncRNA）是指一类长度超过200 nt的非编码RNA。研究证明多种lncRNA及其相关靶调控通路参与急性心肌梗死的发生及发展。现阐述lncRNA及相关调控通路与急性心肌梗死的研究现状，探讨lncRNA及其相关调控通路作为急性心肌梗死诊断的精准生物标志物及治疗、改善预后的潜在靶点的可能性及面临的挑战。
Abstract:
Acute myocardial infarction (AMI) refers to the severe and persistent ischemic necrosis of the corresponding myocardium caused by the sharp decrease or interruption of coronary blood supply. Long non-coding RNA (lncRNA) refers to a class of non-coding RNA whose length exceeds 200 nt. It has been proved that a variety of lncRNA and its related target regulatory pathways are involved in the occurrence and development of AMI. The aim of this article is to elucidate the research status of lncRNAs expression and related regulatory pathways in acute myocardial infarction, and to explore the possibility and challenges of using lncRNA and its related regulatory pathways as precise biomarkers for the diagnosis and treatment of AMI and potential targets for improving prognosis

参考文献/References:

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更新日期/Last Update: 2020-01-19