[1]陈芡茹,综述,叶飞,等.心血管疾病治疗新目标:脂蛋白相关磷脂酶A2[J].心血管病学进展,2016,(2):188-192.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.024]
 CHEN Qianru,YE Fei.Novel Therapeutic Target of Cardiovascular Disease:Lipoprotein Associated Phospholipase A2[J].Advances in Cardiovascular Diseases,2016,(2):188-192.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.024]
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心血管疾病治疗新目标:脂蛋白相关磷脂酶A2()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年2期
页码:
188-192
栏目:
综述
出版日期:
2016-04-20

文章信息/Info

Title:
Novel Therapeutic Target of Cardiovascular Disease:Lipoprotein Associated Phospholipase A2
作者:
陈芡茹综述叶飞审校
南京医科大学附属南京医院 南京市第一医院心血管内科,江苏 南京 210000
Author(s):
CHEN QianruYE Fei
Department of Cardiology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210000,Jiangsu,China
关键词:
脂蛋白相关磷脂酶A2 炎症 动脉粥样硬化 药物治疗
Keywords:
Lipoprotein-associated phospholipase A2 Inflammation Atherosclerosis Pharmacologic therapies
分类号:
R541.4
DOI:
10.16806/j.cnki.issn.1004-3934.2016.02.024
文献标志码:
A
摘要:
在冠状动脉粥样硬化病变的发展和转归中,炎症被认为是一种重要因素。虽然有研究证实多种炎症指标如超敏C反应蛋白和白介素等与冠状动脉斑块的易损性相关,但此类指标均为非特异性; 人血浆脂蛋白相关磷脂酶A2(Lp-PLA2)是一种由炎症细胞产生、存在于粥样硬化斑块中特有的蛋白酶,越来越多的证据表明,Lp-PLA2对炎症的高特异性和低生物差异性使其成为评价斑块易损性的一个“理想指标”,其在血清中的增加与心血管事件密切相关。而且,Lp-PLA2已被认为是一种动脉粥样硬化的特异性药物治疗中的靶向目标,可通过间接(他汀类药物、阿司匹林、β受体阻滞剂)或直接药物(Lp-PLA2抑制剂darapladib)降低血清Lp-PLA2水平进而改善冠心病患者的临床预后。现主要介绍各种药物降低血清Lp-PLA2水平的作用机理及临床研究进展。
Abstract:
Inflammation is clearly recognized as a central component in the development and progression of coronary atherosclerosis.Though many studies have demonstrated high sensitivity C-reactive protein and interleukin without specificity associated vulnerability of atherosclerotic plaque,lipoprotein-associated phospholipase A2(Lp-PLA2)is an enzyme produced in atherosclerotic plaque by inflammatory cells.Increasing evidence has demonstrated Lp-PLA2 as a “ideal” marker for vulnerability of plaque as of its high specificity for inflammation and low biologic variability and Lp-PLA2 levels have shown a significant correlation with cardiovascular events.In addition, Lp-PLA2 has been considered as a special therapeutic target for atherosclerosis, which has been acted upon indirectly(statins, asprin and β-blockers)and directly(Lp-PLA2 antagonists such as darapladib)to improve clinical outcomes.This review will provide an overview on mechanism and clinical progress of various drugs lowering Lp-PLA2 levels.

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备注/Memo

备注/Memo:
作者简介:陈芡茹(1989—),硕士,主要从事冠心病研究。Email:1247826392@qq.com 通信作者:叶飞(1969—),主任医师,博士,主要从事冠心病介入治疗、高血压病研究。Email:yeifei@medmail.com.cn
更新日期/Last Update: 2016-03-25