[1]刘玉莹,杨斌.PCI术后损伤血管再内皮化延迟的机制与治疗研究综述[J].心血管病学进展,2024,(3):248.[doi:10.16806/j.cnki.issn.1004-3934.2024.03.013]
 LIU Yuying,YANG Bin.A Review of the mechanism and therapy of delayed re-endothelialization of injured vessels after PCI[J].Advances in Cardiovascular Diseases,2024,(3):248.[doi:10.16806/j.cnki.issn.1004-3934.2024.03.013]
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PCI术后损伤血管再内皮化延迟的机制与治疗研究综述()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年3期
页码:
248
栏目:
综述
出版日期:
2024-03-25

文章信息/Info

Title:
A Review of the mechanism and therapy of delayed re-endothelialization of injured vessels after PCI
作者:
刘玉莹杨斌
(青岛大学附属医院,山东 青岛 266000)
Author(s):
LIU Yuying YANG Bin
(The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China)
关键词:
经皮冠状动脉介入治疗晚期支架血栓形成血管内皮生长因子RNA结合蛋白药物洗脱支架
Keywords:
Percutaneous coronary intervention Late stent thrombosis Vascular endothelial growth factor RNA binding protein Drug eluting stent
DOI:
10.16806/j.cnki.issn.1004-3934.2024.03.013
文献标志码:
A
摘要:
支架内再狭窄和晚期支架血栓形成是冠状动脉疾病患者行经皮冠状动脉介入治疗后主要的并发症,严重影响了冠状动脉疾病患者的预后,带来不可逆转的危害。在这篇综述中,我们总结了经皮冠状动脉介入治疗术后损伤血管再内皮化延迟的机制,主要包括内皮细胞黏附和增殖的调控,平滑肌细胞黏附和增殖的调控,血小板黏附聚集和活化的调控,以及纤维蛋白原吸收的调控。血管损伤再内皮化延迟的机制调节分子的测定可用于评估动脉损伤程度,为损伤后血管重塑提供了新的思路和治疗靶点。此外,基于冠状动脉疾病患者血管损伤再内皮化延迟的机制,综述了近年来用于改善损伤血管再内皮化的治疗策略,如药物洗脱支架、免疫治疗和基因治疗。总之,我们总结了经皮冠状动脉介入治疗术后内皮化延迟的相关机制和治疗,有利于提升冠状动脉疾病患者行经皮冠状动脉介入治疗的预后。
Abstract:
The main complications of percutaneous coronary intervention mainly contain stent restenosis and late stent thrombosis in patients with coronary artery disease, which exacerbate the progression of coronary artery disease and bring irreversible harm to patients. In this review, we summarize the mechanism of delayed re-endothelialization of damaged blood vessels after percutaneous coronary intervention, such as regulation of endothelial cell adhesion and proliferation, regulation of smooth muscle cell adhesion and proliferation, regulation of platelet adhesion, aggregation and activation, as well as regulation of fibrinogen absorption. The involved mechanism regulatory molecules can be explored as biomarkers for evaluating the degree of arterial injury, providing novel strategies and therapeutic targets for vascular remodeling after injury. In addition, we review a series of treatment strategies for improving the re-endothelialization of damaged vessels in recent years based on the molecular mechanisms of vascular injury in patients with coronary artery disease, mainly including drug eluting stents, immunotherapy, and gene therapy. In summary, we summarize the relevant mechanism and therapy of delayed endothelialization after percutaneous coronary intervention, which is available for improving the prognosis of patients with coronary artery disease after receiving percutaneous coronary intervention.

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更新日期/Last Update: 2024-04-26