[1]王欣笛,苏冠华. MicroRNA-155在高血压发病机制和治疗中的研究进展[J].心血管病学进展,2020,(10):1040.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.010]
 WANG Xindi,SU Guanhua.MicroRNA-155 in Pathogenesis and Treatment of Hypertension[J].Advances in Cardiovascular Diseases,2020,(10):1040.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.010]
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 MicroRNA-155在高血压发病机制和治疗中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年10期
页码:
1040
栏目:
综述
出版日期:
2020-10-25

文章信息/Info

Title:
MicroRNA-155 in Pathogenesis and Treatment of Hypertension
作者:
王欣笛苏冠华
(1.华中科技大学同济医学院第一临床学院,湖北 武汉 430022;2.华中科技大学同济医学院附属协和医院心血管内科,湖北 武汉 430022)
Author(s):
WANG Xindi1SU Guanhua2
(1.First Clinical School,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China; 2.Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China)
关键词:
微小RNA-155高血压血管平滑肌细胞血管紧张素Ⅱ心房利钠肽
Keywords:
MicroRNA-155HypertensionVascular smooth muscle cellsAngiotensin ⅡAtrial natriuretic peptide
DOI:
10.16806/j.cnki.issn.1004-3934.2020.10.010
摘要:
微小RNA-155(miR-155)在高血压的发生发展中起着重要作用,包括参与血管细胞生物学中内皮功能障碍、平滑肌细胞增殖迁移和表型转化、肾素-血管紧张素-醛固酮系统和交感神经活性调节等过程,并介导高血压心、肾损害。左氨氯地平和二甲双胍可通过调控miR-155及相关信号通路发挥心血管保护作用,miR-155有望成为降压药物研发的新靶点。现综述miR-155在高血压发病机制和治疗方面的进展,为进一步认识高血压及其治疗药物的研发提供新思路。
Abstract:
vascular cell biology including endothelial dysfunction, smooth muscle cells proliferation, migration and phenotypical transformation. It is also involved in the activation of renin-angiotensin-aldosterone-system and sympathetic nervous system, which play an important role in the development and progress of hypertension.Furthermore,miR-155 contributes to the injury of heart and kidney in hypertension. S-amlodipine and metformin exert cardioprotective effects by regulating both miR-155 level and its related signal pathway. Therefore, miR-155 is expected to be a novel target for anti-hypertensive drugs development. This review focuses on the effects of miR-155 on the pathogenic mechanisms and treatment of hypertension,and aims to provide further understanding of hypertension,which may contribute to develop novel anti-hypertensive drugs

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备注/Memo

备注/Memo:
收稿日期:2020-05-05基金项目:81700345)
更新日期/Last Update: 2020-12-21