[1]霍敏琪 高红梅 刘芳.心外膜脂肪组织-神经交互与心房颤动的研究进展[J].心血管病学进展,2026,(2):142.[doi:10.16806/j.cnki.issn.1004-3934.2026.02.010]
　HUO Minqi,GAO Hongmei,LIU Fang.Advances in Epicardial Adipose Tissue-Nerve Interaction and Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2026,(2):142.[doi:10.16806/j.cnki.issn.1004-3934.2026.02.010]
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心外膜脂肪组织-神经交互与心房颤动的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2026年2期
页码:
142
栏目:
综述
出版日期:
2026-02-25

文章信息/Info

Title:
Advances in Epicardial Adipose Tissue-Nerve Interaction and Atrial Fibrillation
作者:
霍敏琪1 高红梅2 刘芳2
（1.山东中医药大学第一临床医学院,山东 济南 250014；2.山东中医药大学第二附属医院心血管病科，山东 济南 250001）
Author(s):
HUO Minqi1; GAO Hongmei2; LIU Fang2
?1.The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;2.Division of Cardiology,The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,Shandong,China)
关键词:
心外膜脂肪组织; 心脏自主神经系统; 心房颤动
Keywords:
Epicardial adipose tissue; Cardiac autonomic nervous system; Atrial fibrillation
DOI:
10.16806/j.cnki.issn.1004-3934.2026.02.010
摘要:
心外膜脂肪组织（EAT）是心肌和心外膜内脏层之间的独特脂肪库，与心房颤动（AF）关系密切。近年来，研究发现EAT不仅具有活跃的内分泌和旁分泌功能，还聚集分布着交感和副交感神经纤维。其异常堆积与AF风险显著相关。目前，EAT与自主神经之间的交互机制尚未完全明确。本文系统综述了EAT如何通过脂肪浸润、神经节丛调控以及旁分泌作用与神经系统相互作用，从而促进AF的发生。目前研究发现部分药物通过代谢调节靶向EAT，未来研究需构建精准评估体系，并探索新型治疗策略，为AF防治开辟新方向。
Abstract:
Epicardial adipose tissue (EAT) is a unique fat depot between the myocardium and the visceral layer of the epicardium,which is closely related to atrial fibrillation (AF). In recent years,it has been found that EAT not only has active endocrine and paracrine functions,but also accumulates and distributes sympathetic and parasympathetic nerve fibers. Its abnormal accumulation is significantly associated with the risk of AF. Currently,the interaction mechanism between EAT and autonomic nerves has not been fully clarified. In this paper,we systematically review how EAT interacts with the nervous system through fat infiltration,ganglionic plexus modulation,and paracrine effects to promote AF. The current study found that some drugs target EAT through metabolic regulation,and future research needs to build a precise assessment system and explore novel therapeutic strategies to open up new directions for AF prevention and treatment

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备注/Memo

备注/Memo:
收稿日期：2025-06-24基金项目：国家自然科学基金（82104844）；山东省医药卫生科技发展计划项目（202403010244）；山东省中医药科技发展计划项目（M20241901）
更新日期/Last Update: 2026-05-28