[1]吴元婧 白明.肠道菌群代谢产物对阿霉素心脏毒性的抑制作用[J].心血管病学进展,2025,(11):1006.[doi:10.16806/j.cnki.issn.1004-3934.2025.11.010]
 WU Yuanjing,BAI Ming.Inhibitory Effect of Intestinal Flora Metabolites on Doxorubicin Cardiotoxicity[J].Advances in Cardiovascular Diseases,2025,(11):1006.[doi:10.16806/j.cnki.issn.1004-3934.2025.11.010]
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肠道菌群代谢产物对阿霉素心脏毒性的抑制作用()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年11期
页码:
1006
栏目:
综述
出版日期:
2025-11-25

文章信息/Info

Title:
Inhibitory Effect of Intestinal Flora Metabolites on Doxorubicin Cardiotoxicity
作者:
吴元婧 白明
(兰州大学第一医院,甘肃 兰州 730000)
Author(s):
WU YuanjingBAI Ming
(The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China)
关键词:
阿霉素心脏毒性肠道菌群代谢产物
Keywords:
Doxorubicin CardiotoxicityIntestinal flora metabolites
DOI:
10.16806/j.cnki.issn.1004-3934.2025.11.010
摘要:
阿霉素在肿瘤治疗领域取得了显著成效,但以心力衰竭为主要表现的心脏毒性,对其临床应用产生了阻碍。研究表明,肠道菌群代谢产物与心血管系统相互影响,可通过抗氧化抗炎等机制抑制心脏毒性。现重点讨论肠道菌群代谢产物的重要性及其对阿霉素心脏毒性的积极影响。旨在从肠道菌群代谢产物的角度,为防治阿霉素诱导的心脏毒性提供新的策略。
Abstract:
Doxorubicin has achieved remarkable results in the field of tumor treatment,but its clinical application is hindered by cardiac toxicity,mainly manifested in heart failure. Studies have shown that the intestinal flora metabolites an d the cardiovascular system interact with each other and can inhibit cardiotoxicity through mechanisms such as antioxidation and anti-inflammation. The current focus is on discussing the significance of intestinal flora metabolites and their positive impact on doxorubicin cardiotoxicity. The aim is to provide a new strategy for the prevention and treatment of doxorubicin-induced cardiotoxicity from the perspective of intestinal flora metabolites

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