[1]王鹏 王鑫 张瑶 张经泽 贺世豪 李瑾.内质网应激在阿霉素心脏毒性中作用的研究进展[J].心血管病学进展,2023,(4):341.[doi:10.16806/j.cnki.issn.1004-3934.2023.04.012]
　WANG Peng,WANG Xin,ZHANG Yao,et al.Role of Endoplasmic Reticulum Stress?n the Cardiotoxicity of Doxorubicin[J].Advances in Cardiovascular Diseases,2023,(4):341.[doi:10.16806/j.cnki.issn.1004-3934.2023.04.012]
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内质网应激在阿霉素心脏毒性中作用的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年4期
页码:
341
栏目:
综述
出版日期:
2023-04-25

文章信息/Info

Title:
Role of Endoplasmic Reticulum Stress?n the Cardiotoxicity of Doxorubicin
作者:
王鹏1 王鑫1 张瑶1 张经泽 1 贺世豪1 李瑾2
（1.山西医科大学第二临床医学院,山西 太原 030000;2.山西医科大学第二医院心血管内科,山西 太原 030000)
Author(s):
WANG Peng1;  WANG Xin1;  ZHANG Yao1;  ZHANG Jingze1;  HE Shihao1;  LI Jin2
?1.The Second Clinical Medical College of Shanxi Medical UniversityTaiyuan 030000ShanxiChina2.Department of CardiologyThe Second Hospital of Shanxi Medical UniversityTaiyuan 030000ShanxiChina)
关键词:
内质网应激; 未折叠蛋白反应; 阿霉素; 心脏毒性
Keywords:
Endoplasmic reticulum stress; Unfolded protein response; Doxorubicin; Cardiotoxicity
DOI:
10.16806/j.cnki.issn.1004-3934.2023.04.012
摘要:
阿霉素作为抗肿瘤药，疗效确切，应用广泛，但其具有显著的心脏毒性。细胞受到各种刺激时，内质网内错误折叠蛋白及未折叠蛋白蓄积，产生内质网应激，继而触发未折叠蛋白反应，以恢复细胞内蛋白稳态，但持续激活的未折叠蛋白反应会诱发细胞凋亡。目前认为持续激活的未折叠蛋白反应所致心肌细胞凋亡与阿霉素心脏毒性有关，且许多化合物及药物可能通过抑制内质网应激发挥阿霉素心脏毒性保护作用。现对阿霉素心脏毒性中内质网应激及其所致凋亡以及可能以该途径为靶点保护的化合物及药物进行综述。
Abstract:
As an antitumor drug,doxorubicin is effective and widely used ,but it has significant cardiotoxicity. When cells are subjected to various stimuli,intracellular misfolded or unfolded proteins accumulate,resulting in endoplasmic reticulum stress,which triggers unfolded protein responses to restore intracellular protein homeostasis,but persistently activated unfolded protein responses can induce apoptosis. It is currently believed that cardiomyocyte apoptosis caused by the continuously activated unfolded protein response is related to the cardiotoxicity of doxorubicin,and many compounds and drugs may play a protective effect on the cardiotoxicity of doxorubicin by inhibiting endoplasmic reticulum stress. This article reviews endoplasmic reticulum stress and apoptosis by endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity ,as well as protective compounds and drugs that may target this pathway

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更新日期/Last Update: 2023-05-17