[1]刘志斌,唐毅,胡政琪,等.人附睾蛋白4在心肾疾病中的研究进展[J].心血管病学进展,2024,(12):1110.[doi:10.16806/j.cnki.issn.1004-3934.2024.12.012]
 LIU ZhibinTANG YiHU ZhengqiLIU TianchengPENG JianqiangHE Jin*.Human Epididymal Protein 4 in Cardiovascular and R enal Diseases[J].Advances in Cardiovascular Diseases,2024,(12):1110.[doi:10.16806/j.cnki.issn.1004-3934.2024.12.012]
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人附睾蛋白4在心肾疾病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年12期
页码:
1110
栏目:
综述
出版日期:
2024-12-25

文章信息/Info

Title:
Human Epididymal Protein 4 in Cardiovascular and R enal Diseases
作者:
刘志斌1唐毅12胡政琪1刘天承1彭建强12何晋12*
(1.湖南师范大学附属第一医院 湖南省人民医院心血管内科,湖南 长沙 410005;2.湖南省心力衰竭临床医学研究中心,湖南 长沙 410005)
Author(s):
LIU Zhibin1TANG Yi2HU Zhengqi1LIU Tiancheng1PENG Jianqiang2HE Jin2*
(1.Department of Cardiology,Hunan Provincial People’s Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha 410005,Hunan,China; 2.Clinical Medicine Research Center of Heart Failure of Hunan Province,Hunan Normal University,Changsha 410005,Hunan,China)
关键词:
人附睾蛋白4心力衰竭急性冠脉综合征心肌病慢性肾脏病
Keywords:
Human epididymal protein 4Heart failureAcute coronary syndromeCardiomyopathyChronic kidney disease
DOI:
10.16806/j.cnki.issn.1004-3934.2024.12.012
摘要:
人附睾蛋白4(HE4)为具有2个乳清酸性蛋白四二硫化物核心结构域、124个氨基酸的多肽,是一种乳清酸性蛋白,属于蛋白酶抑制剂家族中的一种。HE4目前广泛应用于妇科相关疾病的诊断及预后评估,近年来研究显示HE4在心血管及肾脏疾病患者中呈现较高水平表达,尤其是在心力衰竭、急性冠脉综合征和心肌病等心血管疾病及慢性肾脏病等肾脏疾病中扮演着重要角色。现对HE4在心血管及肾脏疾病中的研究现状作一综述。
Abstract:
Human epididymis protein 4 (HE4) is a peptide with 2 whey acidic protein four-disculfidecore domains ,consisting of 124 amino acids. It is a whey acidic protein and belongs to the family of protease inhibitors. HE4 is currently widely used in the diagnosis and prognosis assessment of gynecological diseases. In recent years,studies have shown that HE4 exhibits high levels of expression in patients with cardiovascular and renal diseases,especially playing an important role in cardiovascular diseases such as heart failure,acute coronary syndrome,cardiomyopathy,as well as chronic kidney disease. This article provides an overview of the current research status of HE4 in cardiovascular and renal diseases

参考文献/References:

[1] Kirchhoff C,Habben I,Ivell R,et al. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors[J]. Biol Reprod,1991,45(2):350-357.

[2] Sharp JA,Lefèvre C,Nicholas KR. Molecular evolution of monotreme and marsupial whey acidic protein genes[J]. Evol Dev,2007,9(4):378-392.

[3] Galgano MT,Hampton GM,Frierson HF Jr. Comprehensive analysis of HE4 expression in normal and malignant human tissues[J]. Mod Pathol,2006,19(6):847-853.

[4] Bingle L,Cross SS,High AS,et al. WFDC2(HE4):a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung[J]. Respir Res,2006, 7(1):61.

[5] Schummer M,Ng WV,Bumgarner RE,et al. Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas[J]. Gene,1999,238(2):375-385.

[6] Drapkin R,von Horsten HH,Lin Y,et al. Human epididymis protein 4(HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas[J]. Cancer Res,2005,65(6):2162-2169.

[7] Lu R,Sun X,Xiao R,et al. Human epididymis protein 4(HE4) plays a key role in ovarian cancer cell adhesion and motility[J]. Biochem Biophys Res Commun,2012,419(2):274-280.

[8] Moore RG,Brown AK,Miller MC,et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass[J]. Gynecol Oncol,2008,108(2):402-408.

[9] Moore RG,Miller MC,Disilvestro P,et al. Evaluation of the diagnostic accuracy of the risk of ovarian malignancy algorithm in women with a pelvic mass[J]. Obstet Gynecol,2011,118(2 Pt 1):280-288.

[10] LeBleu VS,Teng Y,O’Connell JT,et al. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis[J]. Nat Med,2013,19(2):227-231.

[11] Yamamoto M,Hanatani S,Araki S,et al. HE4 predicts progressive fibrosis and cardiovascular events in patients with dilated cardiomyopathy[J]. J Am Heart Assoc,2021,10(15):e021069.

[12] de Boer RA,Cao Q,Postmus D,et al. The WAP four-disulfide core domain protein HE4:a novel biomarker for heart failure[J]. JACC Heart Fail,2013,1(2):164-169.

[13]Tang Y,Hu Z,Liu Z,et al. HE4 serum levels are associated with poor prognosis in patients with acute heart failure combined with chronic kidney disease[J]. Int J Gen Med,2024,17:1273-1280.

[14] Piek A,Meijers WC,Schroten NF,et al. HE4 serum levels are associated with heart failure severity in patients with chronic heart failure[J]. J Card Fail,2017,23(1):12-19.

[15] Jin Q,Tang Y,Liu Z,et al. Serum human epididymis protein 4 level as a predictor of clinical worsening in idiopathic pulmonary arterial hypertension:a pilot study[J]. BMC Cardiovasc Disord,2020,20(1):175.

[16] Tang Y,Huo X,Liu J,et al. MicroRNA-325-3p targets human epididymis protein 4 to relieve right ventricular fibrosis in rats with pulmonary arterial hypertension[J]. Cardiovasc Ther,2022,2022:4382999.

[17] Liu LCY,Valente MAE,Postmus D,et al. Identifying subpopulations with distinct response to treatment using plasma biomarkers in acute heart failure:results from the PROTECT trial:differential response in acute heart failure[J]. Cardiovasc Drugs Ther,2017,31(3):281-293.

[18] Kilci H,Alt?nbilek E,?etinkal G,et al. Relation of a novel fibrosis marker and post-myocardial infarction left ventricular ejection fraction in revascularized patients[J]. Biomark Med,2021,15(17):1651-1658.

[19]Yan Q,Wu L,Song J,et al. Serum human epididymis protein 4 as a prognostic predictor of new-onset heart failure among women after acute coronary syndrome:a single-center retrospective study[J]. Cardiology,2023,148(3):230-238.

[20] Tang Y,Wang Y,Xu X,et al. Human epididymis protein 4:a novel predictor of ischemic cardiomyopathy[J]. BMC Cardiovasc Disord,2021,21(1):511.

[21] Ogata F,Hanatani S,Nakashima N,et al. Human epididymis protein 4 is a useful predictor of post-operative prognosis in patients with severe aortic stenosis[J]. ESC Heart Fail,2024,11(5):2924-2932.

[22] Luo HL,He C,Xue H,et al. Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy[J]. Clin Biochem,2024,123:110701.

[23] Huang X,Guo X,Yan G,et al. Dapagliflozin attenuates contrast-induced acute kidney injury by regulating the HIF-1α/HE4/NF-κB pathway[J]. J Cardiovasc Pharmacol,2022,79(6):904-913.

[24] Yang Z,Zhang Z,Qin B,et al. Human epididymis protein 4:a novel biomarker for lupus nephritis and chronic kidney disease in systemic lupus erythematosus[J]. J Clin Lab Anal,2016,30(6):897-904.

[25] Ren Y,Xie J,Lin F,et al. Serum human epididymis protein 4 is a predictor for developing nephritis in patients with systemic lupus erythematosus:a prospective cohort study [J]. Int Immunopharmacol,2018,60:189-193.

[26] Li L,Xu H,Le Y,et al. Elevated serum levels of human epididymis protein 4 in adult patients with proliferative lupus nephritis[J]. Front Immunol,2023,14:1179986.

[27] Li Y,Zhong X,Yang F,et al. Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis[J]. Naunyn Schmiedebergs Arch Pharmacol,2024,397(7):4823-4831.

[28] Zhang M,Zhao B,Xie J,et al. Serum human epididymis protein 4 is associated with renal function and diabetic kidney disease in patients with type 2 diabetes mellitus[J]. Biomed Res Int,2019,2019:4831459.

[29] Nagy B Jr,Krasznai ZT,Balla H,et al. Elevated human epididymis protein 4 concentrations in chronic kidney disease[J]. Ann Clin Biochem,2012,49(Pt 4):377-380.

[30] Wan J,Wang Y,Cai G,et al. Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease[J]. Oncotarget,2016,7(42):67748-67759.

[31] Huang Y,Jiang H,Zhu L. Human epididymis protein 4 as an indicator of acute heart failure in patients with chronic kidney disease[J]. Lab Med,2020,51(2):169-175.

[32] Luo J,Wang F,Wan J,et al. Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients[J]. Clin Chim Acta,2018,483:216-221.

[33] Tajima S,Fu R,Shigematsu T,et al. Urinary human epididymis secretory protein 4 as a useful biomarker for subclinical acute rejection three months after kidney transplantation[J]. Int J Mol Sci,2019,20(19):4699.

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更新日期/Last Update: 2025-01-08