[1]岳田 黄刚 杨佳丽 何健 旦增顿珠 高寒 秦珊珊 侯君 徐俊波.姜黄素纳米颗粒联合可注射水凝胶用于改善心肌梗死后微环境的体外效果评价研究[J].心血管病学进展,2024,(2):187.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.018]
　YUE Tian,HUANG Gang,YANG Jiali,et al.Evaluation Study of the in Vitro Effect of Curcumin Nanopartrticle Combined with Injectable Hydrogel for Improving the Microenvironment after Myocardial Infarction[J].Advances in Cardiovascular Diseases,2024,(2):187.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.018]
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姜黄素纳米颗粒联合可注射水凝胶用于改善心肌梗死后微环境的体外效果评价研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年2期
页码:
187
栏目:
论著
出版日期:
2024-02-25

文章信息/Info

Title:
Evaluation Study of the in Vitro Effect of Curcumin Nanopartrticle Combined with Injectable Hydrogel for Improving the Microenvironment after Myocardial Infarction
作者:
岳田 1; 2 黄刚 1 杨佳丽 2 何健 2 旦增顿珠 3 高寒 3 秦珊珊 3 侯君 1 徐俊波 1
(1.成都市第三人民医院心内科,四川 成都 610014;2.西南交通大学生命科学与工程学院,四川 成都 610031;3.西藏大学医学院,西藏 拉萨 850000)
Author(s):
YUE Tian1; 2; HUANG Gang 1; YANG Jiali2; HE Jian 2; Danzen Dunzhu3; GAO Han 3; QIN Shanshan 3; HOU Jun 1; XU Junbo 1
(1.Department of Cardiology,Chengdu Third Peoples Hospital/Affiliated Hospital of Southwest Jiaotong University,Chengdu 610014, China;2.School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031, China3.Medical College,Tibet University,Lhasa 850000, China)
关键词:
心肌梗死; 微环境; 炎症; 活性氧; 心肌细胞凋亡
Keywords:
Myocardial infarction; Microenvironment; Inflammation; Reactive oxygen species; Cardiomyocyte apoptosis
DOI:
10.16806/j.cnki.issn.1004-3934.2024.02.018
摘要:
目的 为探索心肌梗死后的新治疗策略，本研究结合生物材料探索心肌梗死后恶劣微环境的改善策略。方法 通过对生物相容的透明质酸改性与羧甲基壳聚糖共同制备可注射水凝胶，同时制备纳米胶束包载的姜黄素（PP@Cur)用以改善心肌细胞的凋亡。通过流式细胞术、荧光染色验证了Cur纳米胶束的微环境改善作用以及心肌细胞保护作用。结果 Cur纳米颗粒结合水凝胶能够改善心肌梗死后的高炎症和高活性氧环境。结论 生物材料结合纳米递送平台用于梗死心脏微环境改善是可行的并且有望成为心肌梗死治疗的重要研究方向。
Abstract:
Objective In order to explore new therapeutic strategies after myocardial infarction, this study explores the improvement of the harsh microenvironment after myocardial infarction by combining biomaterials. Methods Injectable hydrogels were prepared by biocompatible modified hyaluronic acid and carboxymethyl chitosan , and curcumin nanomicelles (PP@Cur) were prepared to correct the apoptosis of cardiomyocytes. The microenvironmental ameliorating effect and cardiomyocyte protective effect of Cue nanomicelles were verified by flow cytometry and fluorescence staining. Results Cur nanoparticles combined with hydrogel can correct the high inflammation and high reactive oxygen species environment after myocardial infarction. Conclusion The combination of biomaterials and nano delivery platforms for correct the microenvironment of infarcted hearts is feasible and has potential to become an important research direction for the treatment of myocardial infarction.

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更新日期/Last Update: 2024-03-29