[1]王思博 经鹏 杨彤彤 赵迪 王连生.蛋白激酶mTOR调控心肌细胞衰老的机制研究进展[J].心血管病学进展,2024,(5):420.[doi:10.16806/j.cnki.issn.1004-3934.2024.05.009]
　WANG Sibo,JING Peng,YANG Tongtong,et al.Mechanisms of Protein Kinase mTOR Regulating Cardiomyocyte Aging[J].Advances in Cardiovascular Diseases,2024,(5):420.[doi:10.16806/j.cnki.issn.1004-3934.2024.05.009]
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蛋白激酶mTOR调控心肌细胞衰老的机制研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年5期
页码:
420
栏目:
综述
出版日期:
2024-05-25

文章信息/Info

Title:
Mechanisms of Protein Kinase mTOR Regulating Cardiomyocyte Aging
作者:
王思博 经鹏 杨彤彤 赵迪 王连生
(南京医科大学第一附属医院心内科,江苏 南京210029)
Author(s):
WANG Sibo; JING Peng; YANG Tongtong; ZHAO Di; WANG Liansheng
(Department of Cardiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)
关键词:
蛋白激酶; 哺乳动物雷帕霉素靶蛋白; 心肌细胞; 衰老; 心血管疾病
Keywords:
Protein kinase; Mammalian target of rapamycin; Cardiomyocyte; Aging; Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2024.05.009
摘要:
人口老龄化导致心血管疾病的发病率持续增高，机体衰老和心肌细胞衰老常相伴而行。心肌细胞衰老的特征主要表现为氧化应激增加、细胞周期活动停滞、代谢紊乱等，其主要与细胞自噬、线粒体功能障碍、端粒缩短以及慢性炎症等途径有关。而在这些导致心肌细胞衰老的途径中，常伴有蛋白激酶的异常表达和功能障碍。蛋白激酶mTOR可以通过激活一系列级联反应参与到衰老相关的心血管疾病的发生和发展当中。现就mTOR调节心肌细胞衰老的机制进行讨论并总结，提示mTOR可能在未来成为预防或治疗心肌细胞衰老的重要靶点。
Abstract:
The aging of the population has led to a rising incidence of cardiovascular disease,and physical aging often accompanies it. The cardiomyocyte aging is characterized by increased oxidative stress,cell cycle activity arrest,and metabolic disorders,which is mainly associated with molecular effects such as autophagy,mitochondrial dysfunction,telomere shortening and chronic inflammation. Among these pathways leading to cardiomyocyte aging,it is usually accompanied by abnormal expression and dysfunction of protein kinases. Particularly,mTOR can be involved in the generation and development of aging-associated cardiovascular disease through the activation of a series of cascading reactions. In this review,we focus on the mechanisms by which mTOR regulates cardiomyocyte aging,suggesting that mTOR may be an important target for preventing or treating cardiomyocyte aging in the future

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更新日期/Last Update: 2024-06-28