[1]李心瑶 陈俊 李灼.脓毒症心肌病的发病机制研究进展[J].心血管病学进展,2024,(1):44.[doi:10.16806/j.cnki.issn.1004-3934.2023.01.012]
　LI Xinyao,CHEN Jun,LI Zhuo.Pathogenesis of Septic Cardiomyopathy[J].Advances in Cardiovascular Diseases,2024,(1):44.[doi:10.16806/j.cnki.issn.1004-3934.2023.01.012]
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脓毒症心肌病的发病机制研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年1期
页码:
44
栏目:
综述
出版日期:
2024-02-21

文章信息/Info

Title:
Pathogenesis of Septic Cardiomyopathy
作者:
李心瑶 陈俊 李灼
(南京医科大学附属儿童医院急诊/重症医学科,江苏 南京 210008)
Author(s):
LI Xinyao; CHEN Jun; LI Zhuo
(Department Of Emergency/Intensive Care,Childrens Hospital of Nanjing Medical University,Nanjing 210008,Jiangsu,China)
关键词:
脓毒症心肌病; 损伤相关分子模式; 病原体相关分子模式; 线粒体功能障碍; 铁死亡; 细胞焦亡
Keywords:
Septic cardiomyopathy;  Damage-associated molecular pattern;  Pathogen-associated molecular pattern;  Mitochondrial dysfunction;  Ferroptosis;  Pyroptosis
DOI:
10.16806/j.cnki.issn.1004-3934.2023.01.012
摘要:
脓毒症是宿主对感染的反应失调而导致威胁生命的器官功能障碍，脓毒症心肌病是严重脓毒症和脓毒性休克的并发症，死亡率高，预后不良，但目前脓毒症心肌病的病理生理机制暂不明确，尚无针对性的治疗措施。现总结目前关于脓毒症引起心肌功能障碍相关机制的研究现状，为未来的研究和干预方向提供新思路。
Abstract:
Sepsis is a life-threatening organ dysfunction caused by the host’s imbalance in response to infection. Septic cardiomyopathy is a complication of severe sepsis and septic shock ,with high mortality and poor prognosis. However,the pathophysiological mechanism of septic cardiomyopathy is currently unclear ,and there is no targeted treatment measure. The purpose of this review is to summarize the current research on the mechanism of myocardial dysfunction caused by sepsis,and provide new ideas for future research and intervention direction

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更新日期/Last Update: 2024-03-06