[1]李帅 刘富强 王军奎.酒精摄入对肠道菌群的影响及其机制研究进展[J].心血管病学进展,2023,(2):172-176.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.017]
 LI ShuaiLIU FuqiangWANG Junkui.Effects of Alcohol Intake on Intestinal Flora and Its Mechanism[J].Advances in Cardiovascular Diseases,2023,(2):172-176.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.017]
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酒精摄入对肠道菌群的影响及其机制研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年2期
页码:
172-176
栏目:
综述
出版日期:
2023-02-25

文章信息/Info

Title:
Effects of Alcohol Intake on Intestinal Flora and Its Mechanism
作者:
李帅12 刘富强 2 王军奎 2
?1.西安医学院,陕西 西安 710021;2.陕西省人民医院,陕西 西安 710068)
Author(s):
LI Shuai12LIU Fuqiang2WANG Junkui2
(1.Xi’an Medical University Xi’an 710021,Shaanxi,China; 2.Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi,China)
关键词:
酒精摄入肠道菌群菌群失调肠道通透性肠-肝轴肠-脑轴干预策略
Keywords:
Alcohol intakeintestinal floraDysbacteriosisIntestinal permeabilityGut-liver axisGut-brain axisIntervention strategy
DOI:
10.16806/j.cnki.issn.1004-3934.2023.02.017
摘要:
过量酒精摄入可引起肠、肝、脑等靶器官的损伤,促进酒精相关疾病的发生和发展。但目前具体机制尚不明确。近年来,许多研究表明酒精摄入可通过引起粪便pH值升高,影响胆汁酸的分泌和合成等因素导致肠道菌群失调,继而通过肠-肝轴和肠-脑轴引起相应靶器官损伤,促进酒精相关疾病的发生和发展。现综述近年来酒精摄入导致的肠道菌群失调,及其靶器官损伤的分子机制以及酒精诱导的肠道菌群失调的干预策略,以期为酒精相关疾病的治疗提供理论基础和新思路。
Abstract:
Excessive alcohol intake can cause damage to target organs such as intestine,liver and brain and promote the development of alcohol-related diseases. But the exact mechanism is unclear. In recent years,a number of studies have shown that alcohol intake can contribute to intestinal flora dysregulation by causing elevated fecal pH,affecting bile acid secretion and synthesis,it then promotes the development of alcohol-related diseases by causing corresponding target organ injury through the gut-liver axis and gut-brain axis. In this paper,we reviewed the molecular mechanisms of intestinal flora dysregulation caused by alcohol intake ,and its target organ damage,as well as intervention strategies for alcohol-induced intestinal flora dysregulation in order to provide theoretical basis and new ideas for the treatment of alcohol-related diseases.

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更新日期/Last Update: 2023-04-24