[1].胆固醇酯转移蛋白抑制剂在动脉粥样硬化性心血管疾病治疗中的研究进展[J].心血管病学进展,2022,(7):600-604.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
 ZHU Jie,GAO Fen,XUE Shuanqin,et al.Treatment of Atherosclerotic Cardiovascular Diseases with Cholesteryl Ester Transfer Protein Inhibitor[J].Advances in Cardiovascular Diseases,2022,(7):600-604.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
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胆固醇酯转移蛋白抑制剂在动脉粥样硬化性心血管疾病治疗中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年7期
页码:
600-604
栏目:
综述
出版日期:
2022-07-25

文章信息/Info

Title:
Treatment of Atherosclerotic Cardiovascular Diseases with Cholesteryl Ester Transfer Protein Inhibitor
文章编号:
202203001
作者:
(1.山西医科大学,山西 太原 030000;2.山西医科大学第二医院心内科,山西 太原 030000)
Author(s):
ZHU Jie1GAO Fen2XUE Shuanqin1CHEN Lijun1
(1.Shanxi Medical University,Taiyuan 030000,Shanxi,China; 2.Cardiovascular Department,The Second Hospital of Shanxi Medical University,Taiyuan 030000,Shanxi,China)
关键词:
动脉粥样硬化性心血管疾病胆固醇酯转移蛋白胆固醇酯转移蛋白抑制剂
Keywords:
Atherosclerotic cardiovascular diseaseCholesterol ester transfer proteinCholesterol ester transfer protein inhibitor
DOI:
10.16806/j.cnki.issn.1004-3934.2022.07.000
摘要:
动脉粥样硬化性心血管疾病与多种因素相关,其中血脂异常占有极其重要的地位。胆固醇酯转移蛋白抑制剂是一种以升高高密度脂蛋白胆固醇为目标的调血脂药,可联合他汀类药物在降低低密度脂蛋白胆固醇的基础上升高高密度脂蛋白胆固醇水平,从而降低高危患者心血管不良事件风险。现将胆固醇酯转移蛋白抑制剂的作用机制、研究现状和未来前景等进行综述。
Abstract:
Atherosclerotic cardiovascular disease is associated with a number of factors,of which dyslipidaemia plays an important role. Cholesteryl ester transfer protein inhibitors are lipid-modifying drugs that aim to increase high-density lipoprotein cholesterol. It can be combined with statins to increase the level of high-density lipoprotein cholesterol on the basis of reducing low-density lipoprotein cholesterol,thereby reducing the risk of cardiovascular events in high-risk patients. This article reviews the mechanism of action,research status and future prospects of cholesteryl ester transfer protein inhibitors.

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更新日期/Last Update: 2022-08-22