[1]胡美曦 黄志华 柳志红 赵智慧 罗勤 赵青.慢性血栓栓塞性肺动脉高压:构建动物模型的研究进展[J].心血管病学进展,2022,(3):236-240.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
 HU Meixi,HUANG Zhihua,LIU Zhihong,et al.Chronic Thromboembolic Pulmonary Hypertension: Advances in Constructing Animal Models[J].Advances in Cardiovascular Diseases,2022,(3):236-240.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
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慢性血栓栓塞性肺动脉高压:构建动物模型的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年3期
页码:
236-240
栏目:
综述
出版日期:
2022-03-25

文章信息/Info

Title:
Chronic Thromboembolic Pulmonary Hypertension: Advances in Constructing Animal Models
文章编号:
202112042
作者:
胡美曦 黄志华 柳志红 赵智慧 罗勤 赵青
(中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院,北京100037)
Author(s):
HU MeixiHUANG ZhihuaLIU ZhihongZHAO ZhihuiLUO QinZHAO Qing
(Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)
关键词:
慢性血栓栓塞性肺动脉高压动物模型病理生理肺动脉高压
Keywords:
Chronic thromboembolic pulmonary hypertensionAnimal modelsPathogenesis Pulmonary hypertension
DOI:
10.16806/j.cnki.issn.1004-3934.2022.03.000
摘要:
慢性血栓栓塞性肺动脉高压(CTEPH)被认为是急性肺血栓栓塞症的一种长期并发症,然而,研究表明,部分确诊为CTEPH的患者并无症状性肺血栓栓塞的既往病史,提示肺血栓栓塞可能并不是CTEPH的唯一病因。尽管近年来对肺动脉高压的研究取得了广泛的进展,但由于缺乏对CTEPH病理生理学的相关研究,此类患者的综合治疗仍面临许多挑战,且患者的预后不容乐观。因此,建立合理可靠的动物模型以揭示CTEPH的发病机制,对于了解其发生和发展、开展相关的药物治疗研究和制定干预策略具有重要意义。现从动物模型的相关研究进展出发,就近年来国内外有关构建CTEPH实验动物模型的方法作简要的介绍和评价。
Abstract:
Chronic thromboembolic pulmonary hypertension(CTEPH) is considered to be a long-term complication of acute pulmonary thromboembolism. However,studies have shown that some patients diagnosed with CTEPH have no history of symptomatic pulmonary thromboembolism,suggesting that pulmonary thromboembolism is not the sole cause of CTEPH. Despite the extensive progress in recent research on pulmonary hypertension,the lack of relevant studies on the pathophysiology of CTEPH leaves many challenge s of comprehensive treatment for these patients and their prognosis remains poor. Thus,developing reasonable and reliable animal models to reveal the pathogenesis of CTEPH is critical for elucidating its development,conducting relevant drug therapy studies,and developing effective intervention strategies. Based on the progress of recent research,this article will give a brief introduction and evaluation of different CTEPH experimental animal models

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更新日期/Last Update: 2022-04-20