[1]杨双 唐艳红.P2X3受体在心血管疾病中的研究进展[J].心血管病学进展,2022,(2):117.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.006]
 YANG Shuang,TANG Yanhong.P2X3 Receptor in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2022,(2):117.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.006]
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P2X3受体在心血管疾病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年2期
页码:
117
栏目:
综述
出版日期:
2022-02-25

文章信息/Info

Title:
P2X3 Receptor in Cardiovascular Diseases
作者:
杨双 唐艳红
(武汉大学人民医院心内科 武汉大学心血管病研究所 心血管病湖北省重点实验室,湖北 武汉 430060)
Author(s):
YANG ShuangTANG Yanhong
(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute of Wuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060 ,Hubei,China)
关键词:
P2X3受体高血压糖尿病心脏自主神经病变心肌缺血心血管疾病
Keywords:
P2X3 receptorHypertensionDiabetic heart autonomic nerve injuryMyocardial infarctionCardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2022.02.006
摘要:
P2X3受体属于嘌呤能受体P2X受体家族中的一员,主要表达于初级感觉神经元中。ATP作为P2X3受体的天然配体,在病理状态如神经损伤、心肌缺血时释放显著增加。与ATP结合后,P2X3受体将外周信号传入神经中枢,进一步引起病理生理变化。研究证实P2X3受体与各种病理性疼痛,尤其是炎症性疼痛有关。近年来发现P2X3受体在高血压、缺血性心肌损害、心肌梗死、糖尿病心脏自主神经损害等心血管系统疾病中也发挥重要作用。现就P2X3受体的分子结构、分布、功能特性及其在心血管疾病中的研究进展进行综述。
Abstract:
P2X3 receptor, a member of the purinergic receptor P2X receptor family, is mainly expressed in primary sensory neurons. ATP, as the natural ligand of P2X3 receptor, is significantly increased in pathological conditions such as nerve injury and myocardial ischemia. After binding with ATP, P2X3 receptor transmits peripheral signals to the nerve center, further causing pathophysiological changes. P2X3 receptor has been confirmed in various pathologic pain, especially inflammatory pain. In recent years, studies?have also found that P2X3 receptor plays an important role in cardiovascular diseases such as hypertension, myocardial ischemic injury, myocardial infarction and diabetic heart autonomic nerve injury. This paper summarizes the molecular structure, distribution, functional characteristics of P2X3 receptor and its research progress in cardiovascular diseases

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更新日期/Last Update: 2022-08-19