[1]曹岩 颜培实.残余胆固醇与动脉粥样硬化性心血管疾病[J].心血管病学进展,2021,(10):920.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.014]
 CAO Yan,YAN Peishi.Remnant Cholesterol And Atherosclerotic?ardiovascular Disease[J].Advances in Cardiovascular Diseases,2021,(10):920.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.014]
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残余胆固醇与动脉粥样硬化性心血管疾病()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年10期
页码:
920
栏目:
综述
出版日期:
2021-10-25

文章信息/Info

Title:
Remnant Cholesterol And Atherosclerotic?ardiovascular Disease
作者:
曹岩1 颜培实12
(1.大连医科大学研究生院,辽宁 大连 116044;2.大连医科大学附属大连市中心医院心血管内一科,辽宁 大连 116033)
Author(s):
CAO Yan1YAN Peishi12
(1.Dalian Medical University Graduate School,Dalian 116044,Liaoning,China2.Department of Cardiology,Dalian Central Hospital,Dalian Medical University,Dalian 116033,Liaoning,China)
关键词:
残余胆固醇动脉粥样硬化性心血管疾病动脉粥样硬化脂质代谢
Keywords:
Remnant cholesterolAtherosclerotic heart diseaseAtherosclerosisLipid metabolism
DOI:
10.16806/j.cnki.issn.1004-3934.2021.10.014
摘要:
动脉粥样硬化性心血管疾病(ASCVD)是全球公共健康的最大威胁之一,呈高发病率、年轻化的趋势,血脂代谢异常是其主要危险因素。残余胆固醇(RC)是空腹状态下极低密度脂蛋白残粒和中间密度脂蛋白残粒的胆固醇,餐后状态还包括乳糜微粒残粒的胆固醇。越来越多的证据表明,RC的水平与ASCVD的发生有关,特别是当低密度脂蛋白胆固醇在合适水平时,被认为是动脉粥样硬化脂蛋白谱的又一特征。现总结RC的定义、定量评价,并通过流行病学、遗传学证据及治疗等方面探讨RC与ASCVD之间的关系。
Abstract:
Atherosclerotic cardiovascular disease(ASCVD) is one of the biggest threats to public health worldwide. It is a trend of high incidence rate and younger age. Abnormal lipid metabolism is the main risk factor. Remnant cholesterol(RC) is the cholesterol of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) in fasting state,and the cholesterol of chylomicrons in postprandial state. More and more evidence shows that the level of RC is related to the occurrence of ASCVD,especially when LDL-C is at the appropriate level,it is considered to be another feature of atherosclerotic lipoprotein profile.This review summarizes the definition,quantitative evaluation of RC,and demonstrates the relationship between RC and ASCVD through and epidemiology evidence ,genetic evidence and treatment

参考文献/References:

[1]Silverman MG,Ference BA,Im K,et al. Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions:a systematic review and meta-analysis[J]. JAMA,2016,316(12):1289-1297.

[2]Tenenbaum A,Fisman EZ,Motro M,et al. Atherogenic dyslipidemia in metabolic syndrome and type 2 diabetes:therapeutic options beyond statins[J]. Cardiovasc Diabetol,2006,5:20.

[3]Varbo A,Benn M,Tybj?rg-Hansen A,et al. Remnant cholesterol as a causal risk factor for ischemic heart disease[J]. J Am Coll Cardiol,2013,61(4):427-436.

[4]Nordestgaard BG,Benn M,Schnohr P,et al. Nonfasting triglycerides and risk of myocardial infarction,ischemic heart disease,and death in men and women[J]. JAMA,2007,298(3):299-308.

[5]Martin SS,Blaha MJ,Elshazly MB,et al. Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications[J]. J Am Coll Cardiol,2013,62(8):732-739.

[6]Jepsen AM,Langsted A,Varbo A,et al. Increased remnant cholesterol explains part of residual risk of all-cause mortality in 5414 patients with ischemic heart disease[J]. Clin Chem,2016,62(4):593-604.

[7]Lupton JR,Faridi KF,Martin SS,et al. Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile:the Very Large Database of Lipids (VLDL-3) study[J]. J Clin Lipidol,2016,10(1):72-81.e1.

[8]Miller YI,Choi SH,Fang L,et al. Lipoprotein modification and macrophage uptake:role of pathologic cholesterol transport in atherogenesis[J]. Subcell Biochem,2010,51:229-251.

[9]Wang L,Gill R,Pedersen TL,et al. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation[J]. J Lipid Res,2009,50(2):204-213.

[10]Kawakami A,Aikawa M,Alcaide P,et al. Apolipoprotein CⅢ induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells[J]. Circulation,2006,114(7):681-687.

[11]Olufadi R,Byrne CD. Effects of VLDL and remnant particles on platelets[J]. Pathophysiol Haemost Thromb, 2006,35(3-4):281-291.

[12]Langsted A,Madsen CM,Nordestgaard BG. Contribution of remnant cholesterol to cardiovascular risk[J]. J Intern Med,2020,288(1):116-127.

[13]Bittencourt MS,Santos RD,Staniak H,et al. Relation of fasting triglyceride-rich lipoprotein cholesterol to coronary artery calcium score (from the ELSA-Brasil Study)[J]. Am J Cardiol,2017,119(9):1352-1358.

[14]Elshazly MB,Mani P,Nissen S,et al. Remnant cholesterol,coronary atheroma progression and clinical events in statin-treated patients with coronary artery disease[J]. Eur J Prev Cardiol,2020,27(10):1091-1100.

[15]Casta?er O,Pintó X,Subirana I,et al. Remnant cholesterol,not LDL cholesterol,is associated with incident cardiovascular disease[J]. J Am Coll Cardiol,2020,76(23):2712-2724.

[16]Nordestgaard BG,Langsted A,Mora S,et al. Fasting is not routinely required for determination of a lipid profile:clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine[J]. Eur Heart J,2016,37(25):1944-1958.

[17]Nordestgaard BG,Nicholls SJ,Langsted A,et al. Advances in lipid-lowering therapy through gene-silencing technologies[J]. Nat Rev Cardiol,2018,15(5):261-272.

[18]Chapman MJ,Ginsberg HN,Amarenco P,et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease:evidence and guidance for management[J]. Eur Heart J,2011,32(11):1345-1361.

[19]Würtz P,Wang Q,Soininen P,et al. Metabolomic profiling of statin use and genetic inhibition of HMG-CoA reductase[J]. J Am Coll Cardio,2016,67(10):1200-1210.

[20]Kofink D,Eppinga RN,van Gilst WH,et al. Statin effects on metabolic profiles:data from the PREVEND IT (Prevention of Renal and Vascular End-stage Disease Intervention Trial)[J]. Circ Cardiovasc Genet,2017,10(6):e001759.

[21]Miller PE,Martin SS,Joshi PH,et al. Pitavastatin 4 mg provides significantly greater reduction in remnant lipoprotein cholesterol compared with pravastatin 40 mg:results from the short-term phase IV PREVAIL US trial in patients with primary hyperlipidemia or mixed dyslipidemia[J]. Clin Ther,2016,38(3):603-609.

[22]Tsunoda F,Asztalos IB,Horvath KV,et al. Fenofibrate,HDL,and cardiovascular disease in Type-2 diabetes:the DAIS trial[J]. Atherosclerosis,2016,247:35-39.

[23]Fruchart JC,Santos RD,Aguilar-Salinas C,et al. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm:conceptual framework and therapeutic potential:a consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation[J]. Cardiovasc Diabetol,2019,18(1):71.

[24]Aung T,Halsey J,Kromhout D,et al. Associations of Omega-3 fatty acid supplement use with cardiovascular disease risks:meta-analysis of 10 trials involving 77917 individuals[J]. JAMA Cardiol,2018,3(3):225-234.

[25]Bhatt DL,Steg PG,Miller M,et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia[J]. N Engl J Med,2019,380(1):11-22.

[26]Toth PP,Hamon SC,Jones SR,et al. Effect of alirocumab on specific lipoprotein non-high-density lipoprotein cholesterol and subfractions as measured by the vertical auto profile method:analysis of 3 randomized trials versus placebo[J]. Lipids Health Dis,2016,15:28.

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更新日期/Last Update: 2021-12-02