[1]赵琳 孟旭 周宪梁.正常高值血压人群血清炎性标志物研究进展[J].心血管病学进展,2020,(11):1116-1119.[doi:10.16806/j.cnki.issn.1004-3934.2020.11.000]
 ZHAO Lin,MENG Xu,ZHOU Xianliang.Serum Inflammatory Markers in Population with High Normal Blood Pressure[J].Advances in Cardiovascular Diseases,2020,(11):1116-1119.[doi:10.16806/j.cnki.issn.1004-3934.2020.11.000]
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正常高值血压人群血清炎性标志物研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年11期
页码:
1116-1119
栏目:
综述
出版日期:
2020-11-25

文章信息/Info

Title:
Serum Inflammatory Markers in Population with High Normal Blood Pressure
文章编号:
202003069
作者:
赵琳 孟旭 周宪梁
旭 周宪梁 (北京协和医学院 中国医学科学院 国家心血管病中心 阜外医院心血管内科,北京 100037)
Author(s):
ZHAO Lin MENG Xu ZHOU Xianliang
(Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China)
关键词:
正常高值血压炎症因子致病机制
Keywords:
High normal blood pressure Inflammatory factors Pathogenic mechanism
DOI:
10.16806/j.cnki.issn.1004-3934.2020.11.000
摘要:
正常高值血压范围为收缩压在120~139 mm Hg和/或舒张压在80~89 mm Hg的血压水平。正常高值血压人群后续进展为心血管疾病的风险增加。炎症反应在心血管疾病的发展中起重要作用,但有关正常高值血压和炎症反应之间的研究却十分有限。现总结主要炎症因子如C反应蛋白、白介素-17、白介素-6、肿瘤坏死因子、唾液酸和同型半胱氨酸等在正常高值血压人群中的变化,以期为正常高值血压的机制研究、高危人群的筛选以及心血管疾病的防治提供帮助。
Abstract:
High normal blood pressure is defined as a systolic blood pressure of 120 ~139 mm Hg and/or diastolic blood pressure of 80~89 mm Hg. People with high normal blood pressure have an increased risk of developing cardiovascular disease later in life . Although inflammatory reaction plays an important role in the development of cardiovascular disease, the studies on prehypertension and inflammatory responses are scarce. The purpose of this study is to summarize the changes of major inflammatory factors such as C-reactive protein, interleukin 17, interleukin 6, tumor necrosis factor, sialic acid and homocysteine in prehypertensive population. This information will hopefully help with the mechanism research of high normal blood pressure, screening the high-risk groups and the prevention of cardiovascular events

参考文献/References:

[1]Robinson SC,Brucer M. Range of normal blood pressure:a statistical and clinical study of 11,383 persons[J]. Arch Intern Med,1939,64(3):409-444.

[2]Chobanian AV,Bakris GL,Black HR,et al. The Seventh Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure:the JNC 7 report[J]. JAMA,2003,289(19):2560-2572.

[3]Joint Committee for Guideline Revision. 2018 Chinese Guidelines for Prevention and Treatment of Hypertension—a report of the revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension[J]. J Geriatr Cardiol,2019,16(3):182-241.

[4]Wang Y,Wang QJ. The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines:new challenges of the old problem[J]. Arch Intern Med,2004,164(19):2126-2134.

[5]Xu T,Liu J,Zhu G,et al. Prevalence of prehypertension and associated risk factors among Chinese adults from a large-scale multi-ethnic population survey[J]. BMC Public Health,2016,16(1):775.



[6]Chen CY,Yuan ZP. Prevalence and risk factors for prehypertension and hypertension among adults in Central China from 2000-2011[J]. Clin Exp Hypertens,2018,40(8):734-743.

[7]Selassie A,Wagner CS,Laken ML,et al. Progression is accelerated from prehypertension to hypertension in blacks[J]. Hypertension,2011,58(4):579-587.

[8]Vasan RS,Larson MG,Leip EP,et al. Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study:a cohort study[J]. Lancet,2001,358(9294):1682-1686.

[9]Faselis C,Doumas M,Kokkinos JP,et al. Exercise capacity and progression from prehypertension to hypertension[J]. Hypertension,2012,60(2):333-338.

[10] Guo X,Zhang X,Guo L,et al. Association between pre-hypertension and cardiovascular outcomes:a systematic review and meta-analysis of prospective studies[J]. Curr Hypertens Rep,2013,15(6):703-716.

[11] Han M,Li Q,Liu L,et al. Prehypertension and risk of cardiovascular diseases:a meta-analysis of 47 cohort studies[J]. J Hypertens,2019,37(12):2325-2332.

[12] Lewington S,Clarke R,Qizilbash N,et al. Age-specific relevance of usual blood pressure to vascular mortality:a meta-analysis of individual data for one million adults in 61 prospective studies[J]. Lancet,2002,360(9349):1903-1913.

[13] Huang Y,Cai X,Zhang J,et al. Prehypertension and Incidence of ESRD:a systematic review and meta-analysis[J]. Am J Kidney Dis,2014,63(1):76-83.

[14] Huang Y,Cai X,Li Y,et al. Prehypertension and the risk of stroke:a meta-analysis[J]. Neurology,2014,82(13):1153-1161.

[15] Stoll G,Bendszus M. Inflammation and atherosclerosis:novel insights into plaque formation and destabilization[J]. Stroke,2006,37(7):1923-1932.

[16] Dinh QN,Drummond GR,Sobey CG,et al. Roles of inflammation,oxidative stress,and vascular dysfunction in hypertension[J]. Biomed Res Int,2014,2014:406960.

[17] Verma S,Wang CH,Li SH,et al. A self-fulfilling prophecy:C-reactive protein attenuates nitric oxide production and inhibits angiogenesis[J]. Circulation,2002,106(8):913-919.

[18] Fichtlscherer S,Rosenberger G,Walter DH,et al. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease[J]. Circulation,2000,102(9):1000-1006.

[19] Chrysohoou C,Pitsavos C,Panagiotakos DB,et al. Association between prehypertension status and inflammatory markers related to atherosclerotic disease:the ATTICA Study[J]. Am J Hypertens,2004,17(7):568-573.

[20] Pitsavos C,Chrysohoou C,Panagiotakos DB,et al. Abdominal obesity and inflammation predicts hypertension among prehypertensive men and women:the ATTICA Study[J]. Heart Vessels,2008,23(2):96-103.

[21] Zhang S,Xu T,Peng Y,et al. Combined action of C-reactive protein and lipid profiles on risk of hypertension and prehypertension in Mongolian adults in Inner Mongolia, China[J]. Chin Med J (Engl),2014,127(11):2016-2020.

[22] Jinghua L,Tie Z,Ping W,et al. The relationship between serum sialic acid and high-sensitivity C-reactive protein with prehypertension[J]. Med Sci Monit,2014,20:551-555.

[23] 富玮辰,王瑞英.血清尿酸和超敏C-反应蛋白在高血压前期的变化及临床意义[J].中西医结合心脑血管病杂志,2019,17(6):908-910.



[24] Mozos I,Jianu D,Gug C,et al. Links between high-sensitivity C-reactive protein and pulse wave analysis in middle-aged patients with hypertension and high normal blood pressure[J]. Dis Markers,2019,2019:2568069.

[25] Pan L,Li G,Wan S,et al. The association between high-sensitivity C-reactive protein and blood pressure in Yi people[J]. BMC Public Health,2019,19(1):991.

[26] Sesso HD,Buring JE,Rifai N,et al. C-reactive protein and the risk of developing hypertension[J]. JAMA,2003,290(22):2945-2951.

[27] Yao W,Sun Y,Wang X,et al. Elevated serum level of interleukin 17 in a population with prehypertension[J]. J Clin Hypertens (Greenwich),2015,17(10):770-774.

[28] Langenberg C,Bergstrom J,Scheidt-Nave C,et al. Cardiovascular death and the metabolic syndrome:role of adiposity-signaling hormones and inflammatory markers[J]. Diabetes Care,2006,29(6):1363-1369.

[29] Fung MM,Rao F,Poddar S,et al. Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects[J]. Am J Hypertens,2011,24(2):225-233.

[30] 王变丽,任军梅,药华,等.高血压前期人群血管炎性因子的临床分析[J].长治医学院学报,2017,31(2):115-117.

[31] Tseke P,Grapsa E,Stamatelopoulos K,et al. Correlations of sialic acid with markers of i nflammation,atherosclerosis and cardiovascular events in hemodialysis patients[J]. Blood Purif,2008,26(3):261-266.

[32] 柏居林,王伟.血清唾液酸、超敏C反应蛋白与高血压前期的关系及临床意义[J].临床医学研究与实践,2018,3(27):111-112.

[33] Talikoti P, Bobby Z,Hamide A. Hyperhomocysteinemia,insulin resistance and high hs-CRP levels in prehypertension[J]. J Clin Diagn Res,2014,8(8):CC07-CC09.

[34] 侯惠丽,陈瑛,吴萍,等.同型半胱氨酸水平对高血压前期患者进展为高血压的预测价值研究[J].中国全科医学,2018,21(22):2702-2706.

[35] Liu B,Chen Z,Dong X,et al. Association of prehypertension and hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese:a cross-sectional study[J]. BMJ Open,2018,8(3):e019829.

[36] Shields KJ,Stolz D,Watkins SC,et al. Complement proteins C3 and C4 bind to collagen and elastin in the vascular wall:a potential role in vascular stiffness and atherosclerosis[J]. Clin Transl Sci,2011,4(3):146-152.

[37] Han Y,Fukuda N,Ueno T,et al. Role of complement 3a in the synthetic phenotype and angiotensinⅡ-production in vascular smooth muscle cells from spontaneously hypertensive rats[J]. Am J Hypertens,2012,25(3):284-289.

[38] Bao X,Meng G,Zhang Q,et al. Elevated serum complement C3 levels are associated with prehypertension in an adult population[J]. Clin Exp Hypertens,2017,39(1):42-49.

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更新日期/Last Update: 2021-02-02