[1]李一凡 张智伟.巨噬细胞相关的外泌体在心血管疾病中的作用研究进展[J].心血管病学进展,2020,(8):839-843.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.014]
 LI Yifan,ZHANG Zhiwei.Role of Macrophage-Related Exosomes in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2020,(8):839-843.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.014]
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巨噬细胞相关的外泌体在心血管疾病中的作用研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年8期
页码:
839-843
栏目:
综述
出版日期:
2020-08-25

文章信息/Info

Title:
Role of Macrophage-Related Exosomes in Cardiovascular Diseases
作者:
李一凡 张智伟
 (广东省人民医院 广东省医学科学院 广东省心血管病研究所心儿科,广东 广州 510080)
Author(s):
LI Yifan ZHANG Zhiwei
(Department of Pediatric Cardiology,Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong,China)
关键词:
外泌体巨噬细胞心血管疾病
Keywords:
ExosomeMacrophageCardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2020.08.014
摘要:
外泌体是细胞分泌的具有双层磷脂膜结构的囊泡样物质,内部包含蛋白质、核酸等多种物质,介导炎症反应、免疫应答、物质交换及清除等多种机体生理过程,是细胞间通讯的关键介质。近年的研究表明,外泌体参与不同功能表型的巨噬细胞上游或下游水平调控,在心血管疾病发生发展过程中发挥着重要作用。现对巨噬细胞相关的外泌体在心血管疾病发生和发展的作用及机制进行综述,为心血管疾病的诊断及治疗提供新的靶点和思路。
Abstract:
Exosomes are one kind of extracellular vesicles with bilayer phospholipid membrane structure secreted by a variety of cells,which contain many constituents of a cell,including proteins,nucleic acids and other substance.Exosomes are the key mediators for regulating inter-cellular communication,mediating various physiological processes such as inflammatory response,immune response,substance exchange and clearance.Recent studies demonstrated that exosomes participate in upstream and downstream regulation of macrophages of different functional phenotypes,and play an important role in the development of cardiovascular diseases.This article reviews the biomedical function and mechanism of macrophage-related exosomes in the occurrence and development of cardiovascular diseases,providing new targets and ideas for future diagnosis and therapeutic strategies.

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备注/Memo

备注/Memo:
基金项目:广东省医学科学技术研究基金项目(A2019068)
通讯作者:张智伟,E-mail:drzhangzhiwei@126.com
收稿时间:2020-02-17
更新日期/Last Update: 2020-11-02