[1]史云聪 郭艺芳.2型糖尿病和动脉粥样硬化性心血管疾病的关系[J].心血管病学进展,2020,(5):485-490.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.011]
 SHI Yuncong,GUO Yifang.Relationship Between Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2020,(5):485-490.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.011]
点击复制

2型糖尿病和动脉粥样硬化性心血管疾病的关系()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年5期
页码:
485-490
栏目:
出版日期:
2020-05-25

文章信息/Info

Title:
Relationship Between Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease
作者:
史云聪 郭艺芳
(1.河北医科大学研究生院,河北 石家庄050000;2.河北省人民医院老年病一科,河北 石家庄 050000)
Author(s):
SHI Yuncong GUO Yifang
(1.Hebei Medical University Graduate School,Shijiazhuang 050000,Hebei,China; 2. Department of Geriatrics, Hebei People’s Hospital,Shijiazhuang 050000,Hebei,China)
关键词:
动脉粥样硬化性心血管疾病2型糖尿病动脉粥样硬化
Keywords:
Atherosclerotic cardiovascular disease Type 2 diabetes mellitus Atherosclerosis
DOI:
10.16806/j.cnki.issn.1004-3934.2020.05.011
摘要:
动脉粥样硬化性心血管疾病是2型糖尿病患者死亡和残疾的主要原因。2型糖尿病患者发生动脉粥样硬化病变的风险显著高于非糖尿病患者。虽然目前关于2型糖尿病与动脉粥样硬化发生和发展之间的关系尚未完全阐明,但大量基础与临床研究已证实二者之间存在密切的内在联系。现有研究提示,2型糖尿病患者发生动脉粥样硬化病变的机制可能涉及高血糖、胰岛素抵抗、血管钙化、氧化应激、内皮功能障碍和炎症反应等。结合近年来最新的研究结果,现总结分析2型糖尿病与动脉粥样硬化性心血管病之间的潜在联系与可能机制。
Abstract:
Atherosclerotic cardiovascular disease is the principal cause of death and disability among patients with type 2 diabetes mellitus. Patients with type 2 diabetes mellitus have a significantly higher risk of atherosclerotic lesions than non-diabetic patients. Although the relationship between type 2 diabetes mellitus and the development of atherosclerosis has not been fully clarified, a large number of basic and clinical studies have confirmed the close relationship between type 2 diabetes mellitus and atherosclerosis. Available studies suggest that the mechanism of atherosclerotic lesions in type 2 diabetes mellitus patients may involve hyperglycemia, insulin resistance, vascular calcification, oxidative stress, endothelial dysfunction, inflammatory response, etc. Based on the latest research results in recent years, we will summarize and analyze the potential connection and possible mechanism between type 2 diabetes mellitus and atherosclerotic cardiovascular disease in this review article.

参考文献/References:

[1].Shen Y,Cai R,Sun J,et al. Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men:a systematic review and meta-analysis[J]. Endocrine,2017,55(1):66-76.
[2].Rao Kondapally Seshasai S,Kaptoge S,Thompson A,et al. Diabetes mellitus,fasting glucose,and risk of cause specific death[J]. N Engl J Med,2011,364(9):829-841.
[3].Poredos P,Spirkoska A,Lezaic L,et al. Patients with an inflamed atherosclerotic plaque have increased levels of circulating inflammatory markers[J]. J Atheroscler Thromb,2017,24(1):39-46.
[4].Candido R,Bernardi S,Allen TJ. Linking diabetes and atherosclerosis[J]. Expert Rev Endocrinol Metab,2009,4(6):603-624.
[5].Rask-Madsen C,Li Q,Freund B,et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice[J]. Cell Metab,2010,11(5):379-389.
[6].Kernan WN,Viscoli CM,Furie KL,et al. Pioglitazone after ischemic stroke or transient ischemic attack[J]. N Engl J Med,2016,374(14):1321-1331.
[7].Luo JQ,Ren H,Banh HL,et al. The associations between apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphisms and the risk of coronary artery disease in patients with type 2 diabetes mellitus[J]. Front Physiol,2017,8:1031.
[8].Emerging Risk Factors Collaboration,Erqou S,Kaptoge S,et al. Lipoprotein(a) concentration and the risk of coronary heart disease,stroke,and nonvascular mortality[J]. JAMA,2009,302(4):412-423.
[9].Clarke R,Peden JF,Hopewell JC,et al. Genetic variants associated with Lp(a) lipoprotein level and coronary disease[J]. N Engl J Med,2009,361(26):2518-2528.
[10].Kamstrup PR,Tybjaerg-Hansen A,Steffensen R,et al. Genetically elevated lipoprotein(a) and increased risk of myocardial infarction[J]. JAMA, 2009,301(22):2331-2339.
[11].Libby P. Interleukin-1 beta as a target for atherosclerosis therapy:biological basis of CANTOS and beyond[J]. J Am Coll Cardiol,2017,70(18):2278-2289.
[12].Libby P, Hansson GK. Taming immune and inflammatory responses to treat atherosclerosis[J]. J Am Coll Cardiol,2018,71(2):173-176.
[13].Sun Y,He J,Tian J,et al. Association of circulating levels of neopterin with non-culprit plaque vulnerability in CAD patients an angiogram, optical coherent tomography and intravascular ultrasound study[J]. Atherosclerosis,2015,241(1):138-142.
[14].Wu XF,Yang M,Qu AJ,et al. Level of pregnancy-associated plasma protein—A correlates with coronary thin-cap fibroatheroma burden in patients with coronary artery disease:novel findings from 3-vessel virtual histology intravascular ultrasound assessment[J]. Medicine,2016,95(3):e2563.
[15].Gleissner CA,Erbel C,Linden F,et al. Galectin-3 binding protein, coronary artery disease and cardiovascular mortality:insights from the LURIC study[J]. Atherosclerosis,2017,260:121-129.
[16].Andersson C,Enserro D,Sullivan L,et al. Relations of circulating GDF-15,soluble ST2, and troponin-I concentrations with vascular function in the community:the Framingham Heart Study[J]. Atherosclerosis,2016,248:245-251.
[17].Viktorinova A,Svitekova K,Stecova A,et al. Relationship between selected oxidative stress markers and lipid risk factors for cardiovascular disease in middle-aged adults and its possible clinical relevance[J]. Clin Biochem,2016,49(12):868-872.
[18].Zargari M,Sharafeddin F,Mahrooz A,et al. The common variant Q192R at the paraoxonase 1(PON1) gene and its activity are responsible for a portion of the altered antioxidant status in type 2 diabetes[J]. Exp Biol Med,2016,241(14):1489-1496.
[19].Chistiakov DA,Melnichenko AA,Orekhov AN,et al. Paraoxonase and atherosclerosis-related cardiovascular diseases[J]. Biochimie,2017,132:19-27.
[20].Wu D,Wu C,Zhong Y. The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy[J]. J Cell Mol Med,2018,22(9):4283-4291.
[21].Crow JA,Meek EC,Wills RW,et al. A case-control study:the association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus[J]. Diabates Metab Res Rev,2018,34(3):e2967.
[22].Liu G,Ding M,Chiuve SE,et al. Plasma levels of fatty acid-binding protein 4, retinol-binding protein 4, high-molecular-weight adiponectin, and cardiovascular mortality among men with type 2 diabetes:a 22-year prospective study[J]. Arterioscler Thromb Vasc Biol,2016,36(11):2259-2267.
[23].Niinaga R,Yamamoto H,Yoshii M,et al. Marked elevation of serum M2BP-adiponectin complex in men with coronary artery disease[J]. Atherosclerosis, 2016,253:70-74.
[24].Perrotta F,Nigro E,Mollica M,et al. Pulmonary hypertension and obesity:focus on adiponectin[J]. Int J Mol Sci,2019,20(4).pii:e912.
[25].Arce-Cerezo A,García M,Rodríguez-Nuevo A,et al. HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance[J]. Sci Rep,2015,5:14487.
[26].de Rosa S,Chiefari E,Salerno N,et al. HMGA1 is a novel candidate gene for myocardial infarction susceptibility[J]. Int J Cardiol,2017,227:331-334.
[27].Kasmi L,Calderon J,Montreuil M,et al. Neurocognitive and psychological outcomes in adults with dextro-transposition of the great arteries corrected by the arterial switch operation[J]. Ann Thorac Surg,2018,105(3):830-836.
[28].Gleason LP,Deng LX,Khan AM,et al. Psychological distress in adults with congenital heart disease:focus beyond depression[J]. Cardiol Young, 2019,29(2):185-189.
[29].Stout KK,Daniels CJ,Aboulhosn JA,et al. 2018 AHA/ACC guideline for the management of adults with congenital heart disease:executive summary:a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines[J]. Circulation,2019,139(14):e637-e697.
[30].Arzt M,Oldernburg O,Graml A,et al. Phenotyping of sleep-disordered breathing in patients with chronic heart failure with reduced ejection fraction-the SchlaHF registry[J]. J Am Heart Assoc,2017,6(12). pii:e005899.
[31].Oldernburg O,Wellmann B,Buchholz A,et al. Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients[J]. Eur Heart J, 2016,37(21):1695-1703.
[32].[32]Sommerfeld A,Althouse AD,Prince J,et al. Obstructive sleep apnea is associated with increased readmission in heart failure patients[J]. Clin Cardiol, 2017,40(10):873-878.
[33].[33]Hooper L,Martin N,Abdelhamid A,et al. Reduction in saturated fat intake for cardiovascular disease[J]. Cochrane Database Syst Rev,2015,10(6):CD011737.
[34].Wang DD,Li Y,Chiuve SE,et al. Association of specific dietary fats with total and cause-specific mortality[J]. JAMA Intern Med,2016,176(8):1134-1145.
[35].Zhong VW,van Horn L,Cornelis MC,et al. Associations of dietary cholesterol or egg consumption with incident cardiovascular disease and mortality[J]. JAMA,2019,321(11):1081-1095.
[36].Kim Y,Je Y. Dietary fibre intake and mortality from cardiovascular disease and all cancers:a meta-analysis of prospective cohort studies[J]. Arch Cardiovasc Dis, 2016,109(1):39-54.
[37].[37]Reynolds A,Mann J,Cumming J,et al. Carbohydrate quality and human health:a series of systematic reviews and meta-analyses[J]. Lancet,2019,393(10170):434-445.

相似文献/References:

[1]李波 郭毅 田进文 邓珏琳.高血压合并2型糖尿病的治疗进展[J].心血管病学进展,2019,(9):1196.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.002]
 LI Bo,GUO Yi,TIAN Jinwen,et al.Therapy in Hypertensive Patients with Type 2 Diabetes Mellitus[J].Advances in Cardiovascular Diseases,2019,(5):1196.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.002]
[2]李嘉仪 黄龙祥 罗素新.钠-葡萄糖协同转运蛋白-2抑制剂在心血管疾病中的研究进展[J].心血管病学进展,2019,(9):1245.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.015]
 LI JiayiHUANG LongxiangLUO Suxin.SGLT-2 Inhibitors in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(5):1245.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.015]
[3]徐侨 刘正霞 鲁翔.白介素22在动脉粥样硬化和2型糖尿病中的作用[J].心血管病学进展,2019,(9):1260.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.019]
 XU Qiao,LIU Zhengxia,LU Xiang.IL-22 in Atherosclerosis and Type 2 Diabetes Mellitus[J].Advances in Cardiovascular Diseases,2019,(5):1260.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.019]
[4]耿肖囡 肖东斌 魏鑫 惠学志.达格列净对心血管疾病的预防保护机制[J].心血管病学进展,2019,(8):1169.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.025]
 GENG Xiaonan,XIAO Dongbin,WEI xin,et al.Preventive and Protective Mechanism of Dagliflozin for Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(5):1169.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.025]
[5]王菲 卢新政.卡格列净对2型糖尿病患者心血管保护作用的研究进展[J].心血管病学进展,2020,(3):231.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.004]
 WANG Fei,LU Xinzheng.Cardiovascular Protection of Canagliflozin in Type 2 Diabetes Patients[J].Advances in Cardiovascular Diseases,2020,(5):231.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.004]
[6]辛玉晶,刘昊凌.钠-葡萄糖协同转运蛋白2抑制剂与2型糖尿病心血管危险因素的研究进展[J].心血管病学进展,2020,(3):235.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.005]
 XIN Yujing,LIU Haoling.SGLT-2 Inhibitors and Cardiovascular Risk Factors in Type 2 Diabetes Mellitus[J].Advances in Cardiovascular Diseases,2020,(5):235.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.005]
[7]毛玉琳 何胜虎.2型糖尿病和慢性心力衰竭[J].心血管病学进展,2020,(5):491.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.012]
 MAO Yulin,HE Shenghu.Type 2 Diabetes Mellitus and Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2020,(5):491.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.012]
[8]张阳扬 尹德录.新型降糖药物在心力衰竭中的应用前[J].心血管病学进展,2020,(6):599.[doi:10.16806/j.cnki.issn.1004-3934.20.06.010]
 ZHANG Yangyang,YIN Delu.Prospect of New Glucose-lowering Drugs in Heart Failure[J].Advances in Cardiovascular Diseases,2020,(5):599.[doi:10.16806/j.cnki.issn.1004-3934.20.06.010]
[9]李艳茹,白世茹,李如意,等.PCSK9抑制剂在血脂代谢中的研究进展[J].心血管病学进展,2020,(7):729.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.014]
 LI Yanru,BAI Shiru,LI Ruyi,et al.PCSK9 Inhibitors in Lipid Metabolism[J].Advances in Cardiovascular Diseases,2020,(5):729.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.014]
[10]吴易航 张宇辉 张健.SGLT2 i恩格列净对2型糖尿病患者心脏保护作用的研究进展[J].心血管病学进展,2020,(8):787.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.001]
 WU Yihang,ZHANG Yuhui,ZHANG Jian.Progresses on the Cardiovascular Protection of SGLT2 Inhibitor Empagliflozin in Patients with Type 2 Diabetes Mellitus[J].Advances in Cardiovascular Diseases,2020,(5):787.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.001]
[11]蔡薇 杨堰焯 刘昊凌.甘油三酯葡萄糖乘积指数与糖尿病血管病变的研究进展[J].心血管病学进展,2022,(3):245.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
 CAI Wei,YANG Yanzhuo,LIU Haoling.Triglyceride-Glucose Index and Diabetic Vascular Disease[J].Advances in Cardiovascular Diseases,2022,(5):245.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]

备注/Memo

备注/Memo:
收稿日期:2019-11-20
更新日期/Last Update: 2020-08-12