[1]阿依尼尕尔·马木提 周贤惠.光遗传学技术在心律失常研究中的应用及进展[J].心血管病学进展,2020,(7):687-690.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.004]
 Ayinigaer·Mamuti,ZHOU Xianhui.Application and Progress of Optogenetics in Study of Cardiac Arrhythmias[J].Advances in Cardiovascular Diseases,2020,(7):687-690.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.004]
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光遗传学技术在心律失常研究中的应用及进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年7期
页码:
687-690
栏目:
出版日期:
2020-07-25

文章信息/Info

Title:
Application and Progress of Optogenetics in Study of Cardiac Arrhythmias
作者:
阿依尼尕尔·马木提 周贤惠
(新疆医科大学第一附属医院心脏起搏电生理科,新疆 乌鲁木齐 830054)
Author(s):
Ayinigaer·Mamuti ZHOU Xianhui
(Department of Electrophysiology of Cardiac Pacing,The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China)
关键词:
光遗传学心律失常光门控视紫红质通道蛋白2治疗折返
Keywords:
Optogenetics Arrhythmias Optical gating Channelrhodopsin 2 Treatment Reentry
DOI:
10.16806/j.cnki.issn.1004-3934.2020.07.004
摘要:
光遗传学技术作为一种新型技术,将光学与遗传学相结合,运用光学方法对心脏系统进行干扰,为心脏电活动的精确反馈与控制提供了新的工具与方法。目前,光遗传学技术在心律失常领域的应用主要集中在通过控制不同类型的心肌细胞,达到心脏起搏、除颤或复律、终止心律失常和细胞通讯等。它利用光门控心脏离子通道,以一种特定、可逆和无创伤的方式对心律失常进行电调制,从而干预心律失常的治疗。现对近年来光遗传学在心律失常治疗领域中的应用及进展做一系统阐述。
Abstract:
Optogenetics is a kind of new technology combined with genetics and optics,it disturbs the cardiac system by optics,and provides some new tools and methods about accurate feedback and control of the cardiac electrical activity.At present, the application of optogenetics in the field of cardiac arrhythmias,is mainly focused on achieving the cardiac pacing,defibrillation or cardioversion, termination of arrhythmia and cell communication,etc by controlling the different types of myocardial cells. Optogenetics uses optical gating cardiac ion channels to carry out the electromodulation of cardiac arrhythmias by a certain,reversible and noninvasive way, and then to intervene in the treatment of arrhythmias. T he application and progress of optogenetics in the field of arrhythmia treatment in recent years are systematically reviewed i n this article

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81660053)
更新日期/Last Update: 2020-10-09