[1]姚苗苗,秦虹云,胡承平.高血压病对认知功能影响的研究进展[J].心血管病学进展,2020,(3):284-287.[doi:10.16806 /j.cnki.issn.1004-3934.2020.03.017]
 YAO Miaomiao,QIN Hongyun,HU Chengping.Effect of Hypertension on Cognition[J].Advances in Cardiovascular Diseases,2020,(3):284-287.[doi:10.16806 /j.cnki.issn.1004-3934.2020.03.017]
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高血压病对认知功能影响的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年3期
页码:
284-287
栏目:
综述
出版日期:
2020-03-25

文章信息/Info

Title:
Effect of Hypertension on Cognition
作者:
姚苗苗 秦虹云 胡承平
(上海市浦东新区精神卫生中心暨同济大学附属精神卫生中心,上海 200124)
Author(s):
YAO Miaomiao QIN Hongyun HU Chengping
(Department of Psychiatry,Shanghai Pudong New Area Mental Heath Center,Tongji University School of Medicine,Shanghai 200124,China)
关键词:
高血压血管性因素认知功能
Keywords:
HypertensionVascular factorsCognition
DOI:
10.16806 /j.cnki.issn.1004-3934.2020.03.017
摘要:
由于人口老龄化、人口结构变化和缺乏疾病矫正治疗等原因,认知障碍的人数不断增加,且高血压对认知功能的影响越来越受到重视。在老年人群中,不同认知域评估和不同随访设计的临床研究结果显示高血压对认知功能影响并不一致,其作用机制尚不明确。现从流行病学调查结果,就高血压通过血管紧张素系统、动脉粥样硬化、炎症和氧化应激等方面对脑血管结构、功能改变和血脑屏障障碍方面进行讨论以阐述其对认知功能的可能影响。
Abstract:
With the aging of population ,the changes of population structure and the lack of effective intervention and treatment ,the number of people with cognitive impairment is increasing, and there were increasing researches that hypertension plays a role in the pathogenesis of cognitive impairment.In the elderly,the clinical results of different cognitive domains and follow-up designs had show ed that the effect of hypertension on cognition was inconsistent ,and its mechanism was not very clear .The purpose of the current review is to discuss the changes of cerebrovascular structure and function and blood-brain barrier dysfunction in terms of epidemiological findings and hypertension through angiotensin system ,atherosclerosis,inflammation and oxidative stress,in order to elucidate its possible impact on cognitive function.

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备注/Memo

备注/Memo:
收稿日期:2019-08-24 基金项目:上海市浦东新区卫生和计划生育委员会重点学科建设(PWZxk2017-17) 通讯作者:胡承平,E-mail:yaomiaomiao152@163.com
更新日期/Last Update: 2020-05-20