[1]张瑞 毛露 孙硕 Dirk Hermann 陈艾东.内皮素-1干预成为高血压治疗新靶点的展望[J].心血管病学进展,2019,(7):969-972.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.000]
 ZHANG Rui MAO LuSUN ShuoDIRK Hermann CHEN Aidong.The Prospect of Endothelin-1 Intervention as A New Target for the Treatment of Hypertension[J].Advances in Cardiovascular Diseases,2019,(7):969-972.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.000]
点击复制

内皮素-1干预成为高血压治疗新靶点的展望()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年7期
页码:
969-972
栏目:
综述
出版日期:
2019-10-25

文章信息/Info

Title:
The Prospect of Endothelin-1 Intervention as A New Target for the Treatment of Hypertension
作者:
张瑞1 毛露2 孙硕1 Dirk Hermann 3 陈艾东13
(1. 南京医科大学康达学院,江苏 连云港 222000;2. 东南大学附属中大医院,江苏南京 210096;3. 杜伊斯堡-埃森大学神经生物学研究中心,德国 埃森 45122 )
Author(s):
ZHANG Rui 1MAO Lu2SUN Shuo1DIRK Hermann 3 CHEN Aidong13
(1.Kangda CollegeNanjing Medical UniversityLianyungang 2 22000JiangsuChina2. Zhongda Hospital Affiliated to Southeast University Nanjing 210096 JiangsuChina3. Neurobiology Research CenterDuisburg-Essen University Essen 45122 Germany)
关键词:
内皮素-1高血压受体拮抗剂
Keywords:
Endothelin-1HypertensionReceptor antagonist
DOI:
10.16806/j.cnki.issn.1004-3934.2019.07.000
摘要:
内皮素-1(ET-1)引起强烈和持久的血管收缩和血压升高,大量研究表明血浆ET-1水平与很多高血压严重程度高度相关,ET-1参与人类很多类型高血压的发病机制和恶化进展。目前临床高血压治疗并不能很好地改善内皮活性过度增强,这些高浓度的 ET-1 有强大的血管增殖效应,导致血管壁增厚和心肌肥大,可能是造成高血压恶化和加重的关键原因之一。大量研究证实内皮素受体拮抗剂干扰内皮素信号转导途径,无论是动物实验还是临床试验均可很好地降低血压和改善临床症状。内皮素受体拮抗剂在治疗高血压和改善并发症方面具有很高的开发潜力,有望成为高血压治疗新靶点,现就此做一系统阐述。
Abstract:
ET-1 causes strong and long-lasting vasoconstriction and elevated blood pressure. A large number of studies have shown that plasma ET-1 levels are highly correlated with the severity of many hypertension. Endogenous ET-1 is involved in the pathogenesis and deterioration progress of many types of hypertension in humans. At present, the treatment of clinical hypertension does not improve the excessive enhancement of endothelial activity. These high concentrations of ET-1 have strong vascular proliferation eff ects, leading to thickening of blood vessel walls, which may be one of the key reasons for the worsening and aggravation of hypertension.A large number of studies have confirmed that endothelin receptor antagonists interfere with the endothelin signal transduction pathway, regardless of animal experiments or clinical trials can reduce blood pressure and improve clinical symptoms. Endothelin receptor antagonists have high development potential in the treatment of hypertension and improvement of complications, and it is expected to become a new target for hypertension treatment.

参考文献/References:


[1] Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells[J]. Nature,1988,332(6163):411-415.

[2] Trensz F, Bortolamiol C, Kramberg M, et al. Pharmacological characterization of aprocitentan, a dual?endothelin receptor antagonist, alone and in combination with blockers of the renin angiotensin system, in two models of experimental?hypertension[J]. J Pharmacol Exp Ther,2019,368(3):462-473.

[3] Planes N, Digman MA, Vanderheyden PPML, et al. Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1?and the?endothelin-1?ETA?receptors: Influence of ligand binding[J]. Biochim Biophys Acta Gen Subj,2019, 1863(5):917-924.

[4] Huang G, Cheng P, Ding L, et al. Protective effect of Xin-Ji-Er-Kang on cardiovascular remodeling in high salt-induced hypertensive mice[J]. Exp Ther Med,2019,17(3):1551-1562 .

[5] Czopek A, Moorhouse R, Guyonnet L, et al. A novel role for myeloid endothelin-B receptors in hypertension[J].Eur Heart J,2019,40(9):768-784.

[6] Zhang Y, Zhao L, Li H, et al. Risk factors for hypertensive retinopathy in a Chinese population with?hypertension: The Beijing Eye study[J].Exp Ther Med,2019,17(1):453-458.

[7] Gradin K, Persson B. Endothelin A receptor?blockade improves endothelium-dependent relaxation in obese woman[J]. Physiol Res,2018,67(Supplementum 1):S167-S174.

[8] Alrashdi SF, Deliyanti D, Wilkinson-Berka JL. Intravitreal administration of endothelin type A receptor or endothelin type B receptor antagonists attenuates hypertensive and diabetic retinopathy in rats[J]. Exp Eye Res,2018,176:1-9.

[9] Ueno T, Hiwatashi S, Saka R, et al. Pulmonary arterial pressure management based on oral medicine for pediatric living donor liver transplant with portopulmonary?hypertension[J].Transplant Proc,2018,50(9):2614-2618.

[10] Oh DK, Song JM, Park DW, et al. The effect of a multidisciplinary team on the implementation rates of major diagnostic and therapeutic procedures of chronic thromboembolic pulmonary?hypertension[J].Heart Lung,2019,48(1):28-33.



[11] Panozzo CA, Woodworth TS, Welch EC, et a l. Early impact of the ICD-10-CM transition on selected health outcomes in 13 electronic health care databases in the United States[J]. Pharmacoepidemiol Drug Saf,2018,27(8):839-847.

[12] Burnier M. Update on endothelin receptor antagonists in?hypertension[J].Curr Hypertens Rep,2018,20(6):51.

[13] Dawson A, Reddecliffe S, Coghlan C, et al. Safety and feasibility audit of a home-based drug-transitioning approach for patients with pulmonary arterial?hypertension: an observational study[J]. Eur J Cardiovasc Nurs,2018,17(7):612-618.

[14] Gutiérrez A, Contreras C, Sánchez A, et al. Role of phosphatidylinositol 3-Kinase, mitogen-activated protein kinase, and protein kinase c in calcium signaling pathways linked to the α1-adrenoceptor in resistance Arteries[J]. Front Physiol,2019,10(3):55-68.

[15] Jin F. Analysis on mechanism of ATP-sensitive K+?channel opener natakalim improving congestive?heart failure?after myocardial infarction[J].Exp Ther Med,2016,12(6):3993-3997.

[16]Yuzugulen J, Douthwaite JA, Wood EG, et al. Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1[J].Sci Rep,2017,7(1):4956-4963.

[17] 王灵冰,滕欣越,张瑞,等.慢性心力衰竭与血管紧张素Ⅱ相关性分子机制研究进展[J].心血管病学进展, 2018,39(6):963-966.

[18] Skovsted GF, Kruse LS, Berchtold LA, et al. Myocardial ischemia-reperfusion enhances transcriptional expression of?endothelin-1?and vasoconstrictor ETB?receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat[J].PLoS One,2017,12(3): e0174119.

[19] Jacques D, D’Orléans-Juste P, Magder S, et al. Neuropeptide Y and its receptors in ventricular endocardial endothelial cells[J]. Can J Physiol Pharmacol,2017,95(10):1224-1229.



[20]Gergei I, Kr?mer BK, Scharnagl H, et al. Propeptide big-endothelin, N-terminal-pro brain natriuretic peptide and mortality. The Ludwigshafen risk and cardiovascular health (LURIC) study[J].Biomarkers,2017,22(4):315-320.

[21] Thirunavukkarasu C , Yang Y, Subbotin VM, et al.Endothelin receptor antagonist?TAK-044?arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats[J]. Gut, 2004,53(7):1010-1019.

[22]Jen HL, Yin WH, Chen JW, et al. Endothelin-1-induced cell hypertrophy in cardiomyocytes is improved by fenofibrate: possible roles of adiponectin[J].J Atheroscler Thromb,2017,24(5):508-517.

[23] Cassinotti LR, Guil MJ, Sch?ller MI, et al. Chronic blockade of brain?endothelin?receptor type-A (ETA) reduces blood pressure and prevents catecholaminergic overactivity in the right olfactory bulb of?DOCA-salt hypertensive rats[J].Int J Mol Sci,2018,19(3): 660-672.

[24]Seidlmayer LK, Kuhn J, Berbner A, et al.Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes[J]. Cardiovasc Res,2016,112(1):491-501.

[25] Yuan W, Cheng G, Li B, et al. Endothelin-receptor antagonist can reduce blood pressure in patients with hypertension: a meta-analysis[J]. Blood Press,2017,26(2):139-149.

[26] Raymond V, Steven VL, Griet G, et al. D eleting death and dialysis: conservative care of cardiovascular risk and kidney function loss in chronic kidney disease [J].Toxins,2018,10(6): 237-248.

[27] James AA, Richard JA, Christine EW,et al. Distortion of KB?estimates of endothelin-1 ETA?and ETB?receptor antagonists in pulmonary arteries: Possible role of an endothelin-1 clearance mechanism[J]. Pharmacol Res Perspect,2017,5(6): e00374.

[28] Schwabl P,Laleman W. Novel treatment options for portal hypertension[J].Gastroenterol Rep (Oxf),2017,5(2): 90-103.

[29] Hao W, Xuming S, Jeff C, et al. Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: a sex-specific gene profiling analysis[J]. Biochim Biophys Acta,2017, 1863(8):1870-1882.

[30] Pavel J, Tom ás P. Macitentan?in pulmonary arterial hypertension:a focus on combination therapy in the SERAPHIN trial[J]. Am J Cardiovasc Drugs,2018,18(1):1-11.

相似文献/References:

[1]孙刚,黄冠华,综述.高血压合并心力衰竭的治疗策略[J].心血管病学进展,2016,(2):201.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.027]
 SUN Gang,HUANG Guanhua.Treatment Strategy of Hypertension with Heart Failure[J].Advances in Cardiovascular Diseases,2016,(7):201.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.027]
[2]范贵娟,综述,徐瑞,等.盐敏感性高血压的研究进展[J].心血管病学进展,2016,(4):364.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.010]
 FAN Guijuan,XU Rui.Research Progress of Salt Sensitive Hypertension[J].Advances in Cardiovascular Diseases,2016,(7):364.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.010]
[3]陈源源.钙通道阻滞剂在降压治疗中的应用[J].心血管病学进展,2015,(6):662.[doi:10.3969/j.issn.1004-3934.2015.06.002]
 CHEN Yuanyuan.Application of Calcium Channel Blockers in Hypertension Treatment[J].Advances in Cardiovascular Diseases,2015,(7):662.[doi:10.3969/j.issn.1004-3934.2015.06.002]
[4]张毅,柳志红.动态血压监测在高血压中的应用现状与问题[J].心血管病学进展,2019,(6):848.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.003]
 ZHANG Yi,LIU Zhihong.Current status and nsolved Pproblems of Ambulatory Blood Pressure Monitoring for the Management of Hypertension[J].Advances in Cardiovascular Diseases,2019,(7):848.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.003]
[5]黄秋瑾 胡蓉.高血压合并糖尿病患者血压控制率和控制目标的探讨[J].心血管病学进展,2019,(7):973.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.002]
 HUANG QiujinHU Rong.Discussion on Blood Pressure Control Rate and Control Target in Patients with Hypertension Complicated with Diabetes[J].Advances in Cardiovascular Diseases,2019,(7):973.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.002]
[6]张旭明 王曦.高血压对认知功能的影响[J].心血管病学进展,2019,(7):977.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.003]
 ZHANG Xuming,WANG Xi.The Relationship Between Hypertension and Cognitive Function[J].Advances in Cardiovascular Diseases,2019,(7):977.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.003]
[7]凌梦军 陈明凌梦军.阻塞性睡眠呼吸暂停低通气综合征与高血压关系的研究进展[J].心血管病学进展,2019,(5):722.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.015]
[8]李波 郭毅 田进文 邓珏琳.高血压合并2型糖尿病的治疗进展[J].心血管病学进展,2019,(9):1196.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.002]
 LI Bo,GUO Yi,TIAN Jinwen,et al.Therapy in Hypertensive Patients with Type 2 Diabetes Mellitus[J].Advances in Cardiovascular Diseases,2019,(7):1196.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.002]
[9]王继航 赵施皓 李开亮 田进文 李玉龙 付士辉 沈明志 邓珏琳.远程医疗在高血压病管理中的研究进展[J].心血管病学进展,2019,(9):1199.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.003]
 WANG Jihang,ZHAO Shihao,LI Kailiang,et al.Telemedicine in Hypertension Management[J].Advances in Cardiovascular Diseases,2019,(7):1199.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.003]
[10]付士辉李玉龙骆雷鸣沈明志田进文邓珏琳.高血压基础研究现状与进展[J].心血管病学进展,2019,(9):1202.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.004]
 FU ShihuiLI YulongLUO LeimingSHEN MingzhiTIAN JinwenDENG Juelin.Status and Progress of Basic Researches about Hypertension[J].Advances in Cardiovascular Diseases,2019,(7):1202.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.004]

更新日期/Last Update: 2019-12-02