[1]朱月红,戴启明.糖尿病心肌病的内质网病变机制及干预[J].心血管病学进展,2015,(6):738-742.[doi:10.3969/j.issn.1004-3934.2015.06.021]
 ZHU Yuehong,DAI Qiming.Advance of Mechanism and Intervention of Endoplasmic Reticulum in Diabetic Cardiomyopathy[J].Advances in Cardiovascular Diseases,2015,(6):738-742.[doi:10.3969/j.issn.1004-3934.2015.06.021]
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糖尿病心肌病的内质网病变机制及干预()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2015年6期
页码:
738-742
栏目:
综述
出版日期:
2016-06-20

文章信息/Info

Title:
Advance of Mechanism and Intervention of Endoplasmic Reticulum in Diabetic Cardiomyopathy
作者:
朱月红1戴启明2
朱月红1 综述 戴启明2
Author(s):
ZHU Yuehong1DAI Qiming2
1. Southeast University,Nanjng 210096,Jiangsu,China; 2. Zhongda Hospital Affiliated to Southeast University,Nanjng 210009,Jiangsu,China
关键词:
糖尿病心肌病 内质网应激 钙调蛋白 干预
Keywords:
diabetic cardiomyopathy endoplasmic reticulum stress calcium handling proteins intervention
分类号:
R587.2
DOI:
10.3969/j.issn.1004-3934.2015.06.021
文献标志码:
A
摘要:
糖尿病心肌病是糖尿病引起的一种特异性心肌病,它的发病机制非常复杂,其中内质网病变发挥了重要作用。内质网通过内质网应激及钙调蛋白维持心肌细胞功能的稳态,内质网应激一定程度上可以维持蛋白质的正确折叠,严重或长期的内质网应激将启动程序性细胞死亡信号通路; 钙调节蛋白可维持细胞内Ca2+平衡。高糖引起心肌细胞内质网应激及肌浆网上钙调蛋白功能下降,诱导程序性细胞死亡,导致心肌坏死、肥厚、纤维化和心功能不全。为了寻求特异性治疗,国内外都在进行着针对糖尿病心肌病内质网病变干预的研究。现主要对糖尿病
Abstract:
Diabetic cardiomyopathy is a specific cardiomyopathy that is induced by hyperglymia, which mechanisms are still highly elusive. Endoplasmic reticulum plays an important role in the development of diabetic cardiomyopathy as its stress and calcium handling proteins cooperate to keep the myocardial cell properly functioning. The endoplasmic reticulum stress in a certain extent can maintain the protein to correct folding. Serious or long-term endoplasmic reticulum stress will initiate apoptosis and calcium handling proteins may maintain intracellular calcium balance. Hyperglycemia induces endoplasmic reticulum stress and calcium channel destruction, leading to cardiomyocytes apoptosis and abnormal changes in calcium homeostasis, which causes myocardial necrosis, hypertrophy and fibrosis. The aim of this review is to highlight the advances in understanding the mechanism and intervention of the endoplasmic reticulum in the development of diabetic cardiomyopathy.

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备注/Memo

备注/Memo:
作者简介:朱月红(1984—),住院医师,在读硕士,主要从事糖尿病心肌病内质网病变研究。Email:zhuyuehongedu@163.com 通信作者:戴启明(1969—),副主任医师,硕士研究生导师,主要从事糖尿病心肌病研究。Email:dqming@medmail.com.cn
更新日期/Last Update: 2016-06-20