[1]赵珊 张琪.下丘脑室旁核血管紧张素Ⅱ1型受体-Toll样受体4信号介导高血压的研究进展[J].心血管病学进展,2023,(5):460.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.018]
 ZHAO Shan,ZHANG Qi.Angiotensin Type 1 Receptor-Toll-Like Receptor 4 Signaling Mediating Hypertension in Paraventricular Hypothalamic Nucleus[J].Advances in Cardiovascular Diseases,2023,(5):460.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.018]
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下丘脑室旁核血管紧张素Ⅱ1型受体-Toll样受体4信号介导高血压的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年5期
页码:
460
栏目:
综述
出版日期:
2023-05-25

文章信息/Info

Title:
Angiotensin Type 1 Receptor-Toll-Like Receptor 4 Signaling Mediating Hypertension in Paraventricular Hypothalamic Nucleus
作者:
赵珊1 张琪2
(1.陕西中医药大学第二临床医学院,陕西 咸阳 712046;2.陕西中医药大学基础医学院,陕西 咸阳 712046)
Author(s):
ZHAO Shan1ZHANG Qi2
(1.The Second Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China; 2.School of Basic Medical Science,Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China)
关键词:
高血压小胶质细胞下丘脑室旁核
Keywords:
HypertensionMicrogliaParaventricular hypothalamic nucleus
DOI:
10.16806/j.cnki.issn.1004-3934.2023.05.018
摘要:
高血压作为全球公共卫生的一大挑战,尽管其治疗和预防策略随着医学的深入探索而不断发展,但高血压的发病率仍呈上升趋势,且依然是全球范围内的医疗负担。近年来,人们逐渐将治疗措施转向对交感神经的干预。现聚焦于下丘脑室旁核血管紧张素Ⅱ1型受体(AT1R)-Toll样受体4(TLR4)信号介导高血压的新进展,将近来对下丘脑室旁核AT1R-TLR4信号介导高血压形成的研究进行汇总和回顾分析,以期为日后高血压的研究和治疗方案提供新思路。
Abstract:
Hypertension is a significant international public health challenge. Despite the fact that prevention and treatment strategies for hypertension have improved with the depth of medical research,its incidence is continuously rising and continues to pose a serious global health burden. People have been steadily turning to sympathetic nerve intervention as a kind of treatment in recent years. This article focused on new developments in angiotensinⅡtype 1 receptor (AT1R)-Toll-like receptor 4(TLR4) signaling mediating hypertension in the paraventricular hypothalamic nucleus,and summarized and reviewed recent studies on AT1R-TLR4 signaling mediating the formation of hypertension in the paraventricular hypothalamic nucleus,with the aim of providing new ideas for future research and treatment options for hypertension

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更新日期/Last Update: 2023-06-29